On 2 July at 15:00, in an open meeting of the Medical Promotion Council of Rīga Stradiņš University, which will take place in the Hippocrates lecture theatre (Rīga, 16 Dzirciema Str.), Linda Piekuse will defend her doctoral thesis “Impact of Polymorphisms in the Endobiotic and Xenobiotic Metabolsim Involved Enzymes Coding Genes on Chronic Hepatitis C and Acute Toxic Alcohol Induced Hepatitis”.
The author investigated several genetic markers (changes in human genetic material) that would change the ability of human body to react to two the most common causes of liver damage, namely, alcohol and hepatitis C virus and their relation to the course of disease in case of liver damage.
The study included 60 acute toxic hepatitis patients and 233 patients with chronic C virus hepatitis.
After the analysis of eight gene markers within the first patient group, the author detected statistically significant relation between acetylation (one of biochemical decontamination mechanisms in the human body) influencing gene polymorphisms and biochemical indicators that characterise liver damage.
After the analysis of genetic markers that are related to the most common monogenic (caused by the mutation of a single gene) liver diseases and cell’s ability to react to the damage within the cell caused by a virus within the second patient group, the author concluded that clinical gait of hepatitis C virus was influenced by null genotype of GSTM1 gene, polymorphisms of CCR5 gene and SERPINA1 gene. Whereas, after analysis of association of biochemical indicators with the efficiency of antiviral therapy, the author concluded that alongside with the existing indicators, the detection of the level of hyaluronic acid and cytokeratin-18 might be used in the prognosis of the efficiency of antiviral therapy.