On 1 June at 9:00, in a public session of the Doctoral Committee of Medicine, Rīga Stradiņš University, which will take place at the Hippocrates Lecture Theatre (16 Dzirciema Street), Olga Zaikovska will defend her doctoral thesis “Changes of Functional Unit of the Nail for Patients of Onychomycosis”.
Onychomycosis or nail fungus is a topical problem in dermatology. The treatment outcome is individual, recurrence of the disease is often observed, therefore, in-depth knowledge about the processes that occur in the nails is essential. A nail is an interesting though complex material for research, therefore, the topic of morphological changes in nails in case of fungal infection has not been widely studied.
The aim of the study was to examine the functional unit of the nail (nail plate, bed and connective tissues) in case of onychomycosis, assessing the material from various aspects of cell morphology.
To attain the aim of the study, the author took biopsy material (5 mm) of nails affected by onychomycosis for 30 patients. The obtained material was processed and immunohistochemical methods were applied. Nail material of 5 cadavers were used for control purposes.
It was concluded that nails affected by fungus have explicit keratinization disorders and elements of fungi were detected therein. By applying immunohistochemical staining method the author obtained innovative information about unchanged intervention level and hyperplasia of blood-vessels, intensive inflammation and antimicrobial factors, as well as death of significant cells and tissue restructuration in case of this infection