Results | A. Kirchenstein Institute of Microbiology and Virology | Institutes and Laboratories | Structure | Research Organisation | Research | Riga Stradiņš University

 

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5 Rātsupītes Str., Rīga, LV-1069

Phone: +371 29218082

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Results

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Projects

RSU projects

  • RSU scientific project “Connection between fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome and an infection of beta-herpes viruses (HHV-6A, HHV-6B, HHV-7) and parvovirus B19”. Duration: 2013.

  • RSU scientific project “Epidemiology, pathogenicity of human bocavirus (HBoV) types and their possible connection to lower respiratory tract diseases and acute gastroenteritis in children”. Duration: 2013.

  • RSU scientific project “Connection between human heart valve pathologies and parvovirus B19 and herpes virus HHV-6 infections — morphologic, virological and biomechanical aspects”. Duration: 2013.

  • RSU scientific project “Human papilloma virus infection in patients with kidney transplants”. Duration: 2013.

Grants by the Latvian Council of Science

  • Latvian Council of Science cooperation project No. 10.0029. “Innovative approaches to the study of molecular genetic qualities of microorganisms and related systemic damage and the development of individualized monitoring of infectious diseases, diagnostics, therapy methods and technologies”, subproject No. 10.0029.4 “Beta-herpes virus (HHV-6, HHV-7) and parvovirus B19 infections as possible factors in the risk of thyroid autoimmune diseases”. Duration: 2010-2013.

  • Latvian Council of Science project No. 09.1394. “Research of the etiopathogenesis of chronic fatigue syndrome, post-infectious and unspecified cases of encephalopathy, and the development of diagnostic criteria”. Duration: 2009-2012.

  • Latvian Council of Science project No. 09.1392. “The role of Beta-herpes viruses HHV-6A, HHV-6B and HHV-7 in the development of high-malignancy level non-Hodgkin’s lymphomas”. Duration: 2009-2012.

  • Latvian Council of Science project No. 09.1257. “Interaction between virus cells and the host cells: the effect of parvovirus B19 on the expression of host cell genes”. Duration: 2009-2012.

  • Latvian Council of Science project No. 09.1383. “Studies of the biomechanical qualities and bio-compatibility of new nanostructured and composite biomaterials to be used clinically in heart and blood vessel surgery”. Duration: 2009-2012.

  • Latvian Council of Science project No. 09.1112. “Latent/persistent virus infection mechanisms of involvement in the etiopathogenesis of rheumatoid arthritis and osteoarthritis”. Duration: 2009-2012.

  • Latvian Council of Science project No. 478/2012 “Establishing the role of Beta-herpes viruses HHV-6 and HHV-7 in the development of encephalopathy, encephalitis and epilepsy, using a multidisciplinary approach”. Duration: 2013-2016.

National research programmes projects

  • NRP (National research programme) “Scientific research of the main pathologies that threaten the survival rate and quality of life in the Latvian population with the help of a multidisciplinary research consortium”, project No. 11 “Immunomodulative viruses, the diagnostic strategy for their infections and therapy adjustment possibilities”. Duration: 2006-2009.

  • NRP “Development of new prophylactic, therapeutic, diagnostic means and measures and biomedicine technologies with the aim of improving public health”, project No. 9. “Interaction between infectious agents and the genetic background of the host organism”, subproject 9.2. “Interaction between infectious agents and the genetic background of the host organism”. Duration: 2010-2013.

Projects implemented within the scope of EU programmes

  • EU project “Unlocking infectious diseases research potential at Riga Stradiņš University” (BALTINFECT) FP7-REGPOT-2012-2013-1. Duration: 2013-2015

EU structural funds and INTERREG projects

  • ESF (European Social Fund) activities 1.1.1.2. “Human resource engagement in science” project “Formation of a new interdisciplinary group to develop nanotechnology-based approaches in cell biology with application in medicine”. Duration: 2010-2013.

  • Project co-financed by ERDF (European Regional Development Fund) “Development of new natural immunomodulator compositions and study of their efficiency in oncological and viral disease cases”. Duration: 2010-2012.

  • Project co-financed by ESF “Support for doctoral students’ acquisition of the study programme and acquisition of a scientific degree in Riga Stradiņš University”. Duration: 2010-2013.

International cooperation projects

  • Bilateral collaborative project with the Belarusian Research Institute for Epidemiology and Microbiology of the Ministry of Health of the Republic of Belarus “Молекулярно-биологический мониторинг персистентных вирусных инфекций как возможноных тригерфакторов развития синдрома хронической усталости”. Duration: 2009-2011.

  • Collaborative project with the Institute of Experimental Pathology and Parasitology of the Bulgarian Academy of Sciences “Biological aspects of blood-borne viral infections”. Duration: 2009-2013.

Projects financed by other international institutions

  • COST project “European Network for Translational Immunology Research and Education (ENTIRE): From immunomonitoring to personalized immunotherapy”. Duration: 2010-2014

Publications

2013

  • Veinalde R, Ozola A, Azarjana K, Molven A, Akslen LA, Doniņa S, Proboka G, Cēma I, Baginskis A, Pjanova D. Analysis of Latvian familial melanoma patients shows novel variants in the noncoding regions of CDKN2A and that the CDK4 mutation R24H is a founder mutation. Melanoma Res. 2013 Jun;23(3):221-6. doi: 10.1097/CMR.0b013e3283608695; PMID: 23546221
  • Ozola A, Azarjana K, Doniņa S, Proboka G, Mandrika I, Petrovska R, Cēma I, Heisele O, Eņģele L, Streinerte B, Pjanova D. Melanoma risk associated with MC1R gene variants in Latvia and the functional analysis of rare variants. Cancer Genet. 2013 Mar;206(3):81-91. doi: 10.1016/j.cancergen.2013.01.002. Epub 2013 Mar 20.
  • Folkmane I, Čapenko S, Ādamsone I, Folkmane E, Murovska M. Assassment of HHV-6 and HHV-7 in patients after kidney transplantation. Proc. of the Latvian Academy of Sciences. 2013 (nr.1; vol.67): 24-27.
  • Ziediņa I, Čapenko S, Murovska M. Long-term outcome of screening for polyoma BK virus infection in kidney transplant recipients. Proc. of the Latvian Academy of Sciences. 2013 (nr.1; vol.67): 47-51.
  • Shevchuk Z, Yurchenko MY, Darekar SD, Holodnuka-Kholodnuk I, Kashuba VI, Kashuba EV. Overexpression of MRPS18-2 in cancer cell lines results in appearance of multinucleated cells. ActaNaturae, January-March, vol 5, N 1(16) 2013: 85-89.
  • Sultanova A, Chistjakovs M, Chapenko S, Donina S, Murovska M. Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development. Exp Oncol. 2013 Jun;35(2): 93-6.
  • Stradins P, Kalejs M, Priedite V, Lacis R, Ozolanta I, Murovska M, Kasyanov V. Fibrobroblast growth on nanofiber material matrices and changes to their mechanical properties. Int J of Materials, Mechanics and Manufacturing, Vol. 1, No.3 August 2013: 328-331.
  • Kalejs M, Stradins P, Lacis R, Ozolanta I, Murovska M, Kasyanov V. Search of electrospun nanofiber materials matching the mechanical properties of native aortic valve. Int J of Materials, Mechanics and Manufacturing, Vol. 1, No.3 August 2013:261-264.
  • Grāvelsiņa S, Sultanova A, Čapenko S, Cunskis E, Nora-Krūkle Z, Murovska M. Cilvēka herpesvīrusa 6 un 7 un parvovīrusa B19 izplatība pacientiem ar dažādas patoģenēzes vairogdziedzera slimībām. RSU Zinātniskie raksti 2012.gads, 2.sēj. Internā medicīna, Ķirurģija, Medicīnas bāzes zinātnes, Stomatoloģija, Farmācija, 2013: 113-120.
  • Rasa S, Vītols G, Jermolajevs J, Peškova L, Jaunalksne I, Matjušenko N, Ažēna E, Kozlovs V, Doniņa S. Šūnu imunitātes novērtējums pacientēm ar dzimumorgānu audzējiem pēc imūnmodulācijas ar preparātu Glycomune Beta Glucan. RSU Zinātniskie raksti 2012.gads, 2.sēj. Internā medicīna, Ķirurģija, Medicīnas bāzes zinātnes, Stomatoloģija, Farmācija, 2013: 128-137.
  • Rasa S, Čapenko S, Krūmiņa A, Nora-Krūkle Z, Murovska M. Ksenotropā peļu leikozes vīrusam radniecīgā vīrusa, cilvēka herpesvīrusa-6, herpesvīrusa-7 un parvovīrusa B19 saistība ar hroniskā noguruma sindromu/miaļģisko encefalomielītu. RSU Zinātniskie raksti 2012.gads, 1.sēj. Internā medicīna, Ķirurģija, Medicīnas bāzes zinātnes, Stomatoloģija, Farmācija, 2013: 242-249.

2012

  • Vilks A, Donina S, Murovska M, Mamaja B. The Differences of postperative period in association with beta-herpesvirus infection activation depending on the anaesthesia method applied for prolonged reconstructive surgeries. Rīga Stradiņš University Collection of Scientific Papers 2011 “Research articles in medicine & pharmacy”, 2012: 48-53.
  • Čapenko S, Kozireva S, Folkmane I, Bernarde K, Rozentāls R, Murovska M. Anemia as a complication of parvovirus b19 infection in renal transplant recipients. Medicina (Kaunas). 2012;48(6):299-304. PMID: 22885363.
  • Groma V, Kazanceva A, Nora-Krukle Z, Murovska M. Oropharyngeal malignant epithelial cell, lymphocyte and macrophage CD44 surface receptors for hyaluronate are expressed in sustained EBV infection: Immunohistochemical data and EBV DNA tissue indices. Pathol Res Pract. 2012 Sep 15;208(9):518-526. Epub 2012 Jul 6.PMID: 22770970.
  • Zayakin P, Ancāns G, Siliņa K, Meistere I, Kalniņa Z, Andrejeva D, Endzeliņš E, Ivanova L, Pismennaja A, Ruskule A, Doniņa S, Wex T, Malfertheiner P, Leja M, Linē A. Tumor-associated autoantibody signature for the early detection of gastric cancer Int J Cancer. 2012 Jun 9.; 137-147. PMID: 22684876.
  • Macuks R, Baidekalna I, Donina S. An ovarian cancer malignancy risk index composed of HE4, CA125, ultrasonographic score, and menopausal status: use in differentiation of ovarian cancers and benign lesions. Tumour Biol. (2012) 33:1811-1817. PMID: 22696162.
  • Macuks R, Baidekalna I, Donina S. Urinary concentrations of human epidydimis secretory protein 4 (he4) in the diagnosis of ovarian cancer: a case- control study. Asian Pac J Cancer Prev. 2012;13(9):4695-4698. PMID:23167404.
  • Chapenko S, Krumina A, Logina I, Rasa S, Chistjakovs M, Sultanova A, Viksna L, Murovska M. Association of active human herpesvirus-6, -7 and parvovirus B19 infection with clinical outcomes in patients with myalgic encephalomyelitis/chronic fatigue syndrome. Adv Virol. 2012; 2012:205085. PMID:22927850.
  • Stankevica J, Macuks R, Baidekalna I, Donina S. Midline involvement as a risk factor for vulvar cancer recurrence. Asian Pac J Cancer Prev. 2012;13(10):5237-5240. PMID:23244142
  • Vainauska D, Kozireva S, Karpovs A, Cistjakovs M, Bariševs M. A novel approach for nucleic Acid delivery into cancer cells. Medicina (Kaunas). 2012;48(6):324-329. PMID:22885367.
  • Chapenko S, Trociukas I, Donina S, Chistyakov M, Sultanova A, Gravelsina S, Lejniece S, Murovska M. Relationship between beta-herpesviruses reactivation and development of complications after autologus peripheral blood stem cell transplantation. J Med Virol, 2012;84(12):1953-1960. doi: 10.1002/jmv.23412.
  • Spaka I, Birkenfelde R, Kozireva S, Osmjana J, Upmane M, Kashuba E, Kholodnuk (Holodnuka) I. Phetonotypes of B Cells Differ in EBV-positive Burkitt’s Lymphoma Derived Cell Lines. World Academy of Science, Engineering and Technology, December 22-23, Bangkok, Thailand, 2012 (issue 72):793-796.

2011

  • Carruthers B M, van de Sande M I, De Meirleir K L, Klimas N G, Broderick Gitchell T, Staines D, Powles A P, Speight N, Vallings R, Bateman L, Baumgarten-Austrheim B, Bell D S, Carlo-Stella N, Chia J, Darragh A, Jo D, Lewis, D, Light A R, Marshall-Gradisbik S, Mena I, Mikovits J A, Miwa K, Murovska M, Pall, M L, Stevens S. Myalgic Encephalomyelitis: International Consensus Criteria. J, Intern Med. 2011:327-338. PMID: 21777306.
  • Rivkina A, Vitols G, Murovska M, Lejniece S. Identifying the stage of new CLL patients using TK, ZAP-70, CD38 levels. Exp Oncol. 2011; 33(2):99-103. PMID: 21716207.
  • Macuks R, Baidekalna, I, Donina S. Diagnostic test for ovarian cancer composed of ovarian cancer symptom index, menopausal status and ovarian cancer antigen CA125. Eur J Gynaecol Oncol. 2011; 32(3):286-8. PMID: 21797118.
  • Macuks R, Baidekalna I, Donina S. Comparison of different ovarian cancer detection algorithms. Eur J Gynaec Onc, 2011; (4):408-410. PMID: 21941963.
  • Nora-Krukle Z, Chapenko S, Logina I, Millers A, Platkajis A, Murovska M. Human Herpesvirus 6 and 7 Reactivation and Disease Activity in Multiple Sclerosis. MEDICINA (Kaunas), 2011; 47(10):527-531. PMID: 22186115.
  • Macuks R, Baidekalna I, Avdejeva A, Gritcina J, Donina S. Comparison of Two Novel Biomarker Panels in Ovarian Cancer Diagnosis for Patients with a Pelvic Mass. EJCMO, 2011, 3:(4). www.slm-oncology.com
  • Vainauska D, Kozireva S, Karpovs A, Chistyakovs M, Baryshev M. Imroved Technique of Non-viral Gene Delivery Into Cancer cells. World Academy of Science, engineering and technology, An Int J of Sci, Engineering and Technol, Cemal ARDIL, EiC, Bali; October 2011; Issue 58, pISSN 2010-376X; eISSN 2010-3778.
  • Baryshev M, Vainauska D, Kozireva S Karpovs A. New Device For Enhancement of Liposomal Magnetofection Efficiency of Cancer Cells. World Academy of Science, engineering and technology, An Int J of Sci, Engineering and Technol, Cemal ARDIL, EiC, Bali; October 2011; Issue 58, pISSN 2010-376X; eISSN 2010-3778.
  • Logina I, Krumina A, Chapenko S, Rasa S, Chistyakov M, Sultanova A, Murovska M. Pain in chronic fatique syndrome/myalgic encephalomyelitis patients: relation to active HHV-6, HHV-7 and parvovirus B19 infection/co-infection. European J of Pain, 2011:127.
  • Gravelsina S, Nora-Krukle Z, Chapenko S, Sultanova A, Boka V, Cunskis ., Murovska M. Incidence of Human Herpesvirus 6,7, and Parvovirus B19 infection in Patients with Thryoid Gland Disorders. Минск, Сборник научных трудов "Современные проблемы инфекционнои патолоии заболевании человека". Выпуск 4, 2011:341-346
  • Chapenko S, Ziedina I, Folkmane I, Sultanova A, Rozental R, Murovska M. The impact of Beta-herpesviruses Infection Activation on Early Complications Development Following Renal Transplantation. Минск, Сборник научных трудов "Современные проблемы инфекционнои патолоии заболевании человека". Выпуск 4, 2011:330-336.
  • Mačuks R, Baidekalna I, Nuķe I, Doniņa S. Role of a combined soluble interleukine-2 receptor alpha (SIL-R2α) and CA-125 serum marker assay for detection of ovarian cancer. Proceedings of the Latvian Academy of Sciences. Section B, Vol 65 2011, (No 1/2): 7-12. ISSN 1407-009X.
  • Mamaja B, Petersone S, Jaunberga Z, Klaucane A, Zarina A, Vitols E, Krumina G. Assessment of Two Sedation Methods during Magnetic Resonace Imaging for Children with Neurological Deficiency. Rīga Stradiņš University Collection of Scientific Papers 2009 “Research articles in medicine & pharmacy”, 2011:73-77.
  • Vilks A, Donina S, Murovska M, Mamaja B. The effect of Regional and General Anaesthesia on Activation of beta-Herpesviruses and Immune Response. Rīga Stradiņš University Collection of Scientific Papers 2009 “Research articles in medicine & pharmacy”, 2011:95-99.
  • Rivkina A, Lejniece S, Vitols G, Murovska M. The Thymidine Kinease’s Level Correleation with Different Clinical Parametrs of Chronic Lymphocytic Leukemia Patients. Rīga Stradiņš University Collection of Scientific Papers 2009 “Research articles in medicine & pharmacy”, 2011:29-34.
  • Holodnuka I, Kozireva S, Rivkina A, Lejniece S, Murovska M, Imreh S. Transcription of B-cell Surface Chemokine Receptors CCR1 and CCR2 in EBV-negative Malignant and EBV-positive Non-malignant B-cell Lines. Rīga Stradiņš University Collection of Scientific Papers 2009 “Research articles in medicine & pharmacy”, 2011:122-127.
  • Donina S. Immunosupresive Effects of HHV-6 and HHV-7: Clinical Importance. Presentation Summaries, Workshop “Immunomodulating Human Herpesviruses and their Role in Human Pathologies”, RSU, October 13-14, 2011:6-8.
  • Jaunalksne I. HHV-6/HHV-7 Similarities and Differences. Presentation Summaries, Workshop “Immunomodulating Human Herpesviruses and their Role in Human Pathologies”, RSU, October 13-14, 2011:8-10.
  • Logina I, Nora-Krukle Z, Chapenko S, Murovska M. Herpesviruses Infection and Diseases of Nervous System. Presentation Summaries, Workshop “Immunomodulating Human Herpesviruses and their Role in Human Pathologies”, RSU, October 13-14, 2011:10-15.
  • Rasa S, Chapenko S, Krumina A, Chistjakovs M, Viksna L, Logina I, Gintere S, Murovska M. Role of Beta-herpesviruses Infection in the Development of Chronic Fatigue Syndrome/Myalgic Enchephalomyelitis. Presentation Summaries, Workshop “Immunomodulating Human Herpesviruses and their Role in Human Pathologies”, RSU, October 13-14, 2011:16-20.
  • Folkmane I, Chapenko S, Adamsone I, Folkmane E, Sultanova A, Murovska M, Rozentals R. Assasment of HHV-6 and HHV-7 in Patients After Kidney Transplantation: Impact on Clinical and Immune Parameters. Presentation Summaries, Workshop “Immunomodulating Human Herpesviruses and their Role in Human Pathologies”, RSU, October 13-14, 2011:20-24.
  • Trociukas I, Chapenko S, Sultanova A, Gravelsina S, Chistjakovs M, Donina S, Lejniece S, Murovska M. Relationship Between Beta-herpesviruses Reactivation and Complications Development after Peripheral Blood Stem Cell Transplantation. Presentation Summaries, Workshop “Immunomodulating Human Herpesviruses and their Role in Human Pathologies”, RSU, October 13-14, 2011:25-29.
  • Spaks A, Birkenfelde R, Spaka I, Rivkina A, Upmane M, Sasoveca I, Lejniece S, Kalnina V I, Holodnuka I. Presence of HHV-6A, HHV-7B and RBV DNA in Peripheral Blood of Primary Chronic Lymphocytic Leukemia Patients and its Influence on B-Cell Subpopulation Profile. Presentation Summaries, Workshop “Immunomodulating Human Herpesviruses and their Role in Human Pathologies”, RSU, October 13-14, 2011:30-35.
  • Donina S, Jaunalksne I, Chapenko S, Sultanova A, Chistjakovs M, Murovska M. Cellular Immune Response in HHV-6/-7 Infected Gastrointestinal Cancer Patients. Presentation Summaries, Workshop “Immunomodulating Human Herpesviruses and their Role in Human Pathologies”, RSU, October 13-14, 2011:36-40.
  • Vilks A, Rasa S, Donina S, Chapenko S, Mamaja B, Murovska M. Effect of General and Regional Anaesthesia on Activation of Beta-herpesviruses, Immune Response and Postoperative Period in Prolonged Reconstructive Surgeries. Presentation Summaries, Workshop “Immunomodulating Human Herpesviruses and their Role in Human Pathologies”, RSU, October 13-14, 2011:41-45.
  • Kadisa A, Nora-Krukle Z, Kozireva S, Studers P, Lejnieks A, Murovska M. Frequency of HHV-6 and HHV-7 Infection Markers in Rheumatoid Arthritis and Osteoarthritis patients. Presentation Summaries, Workshop “Immunomodulating Human Herpesviruses and their Role in Human Pathologies”, RSU, October 13-14, 2011:46-50.
  • Nora-Krukle Z, Sultanova A, Gravelsina S, Chapenko S, Boka V, Cunskis E, Murovska M. Association of HHV-6 and HHV-7 With Diseases of Thyroid Gland. Presentation Summaries, Workshop “Immunomodulating Human Herpesviruses and their Role in Human Pathologies”, RSU, October 13-14, 2011:57-61.
  • Vitols G, Peskova L, Rudevica Z, Jermolajevs J. Usage of Natural Glycopeptide for Treatment of Herpesviruses Infection. Presentation Summaries, Workshop “Immunomodulating Human Herpesviruses and their Role in Human Pathologies”, RSU, October 13-14, 2011:62-66.
  • Kalnina V I. Antiviral Agents Active Against HHV-6 and HHV-7. Presentation Summaries, Workshop “Immunomodulating Human Herpesviruses and their Role in Human Pathologies”, RSU, October 13-14, 2011:66-69.
  • Vilks A, Rasa S, Krustiņš J, Murovska M, Mamaja B. The Detection of Beta-Herpesvirus Infection in Patiens undergioing Reconstructive Flap Surgeries and Its Association with the nearest Postperative Period Course. Acta Chirurgica Latviensis, 2011:104-110.

2010

  • Bratslavska O, Kozireva S, Uzameckis D, Russev R, Murovska M. Parvovirus B19 infection in non-permisive cells: primary sinovial fluid cells and epithelial-like cells of HOS TE85 cell line. Rīga Stradiņš University Collection of Scientific Papers 2009 “Research articles in medicine & pharmacy”, 2010:89-95.
  • Macuks R, Baidekalna I, Gritcina J, Avdejeva A, Donina S. Apolipoprotein A1 and transferrin as biomarkers in ovarian cancer diagnosis Acta Chirurgica Latviensis, 2010 (10):16-20.
  • Kakurina N, Kadisa A, Lejnieks A, Mikazane H, Kozireva S, Murovska M. The Usage of Exploratory Factor Analysis for determination of the association between human parvovirus B19 infection activity and Rheumatoid arthritis clinical activity. Medicina (Kaunas).

2009

  • Kasyanov V, Hodde J, Hiles M.C, Eisenberg C, Eisenberg L, De Castro LEF, Ozolanta I, Murovska M, Draughn AR. Rapid biofabrication of tubular tissue constructs by centrifugal casting in a decellularized natural scaffold with laser-machined micropores. Prestwich G.D., Markwald R.R., Mironov V. J Mater Sci Mater Med. 2009 Jan;20(1):329-37. PMID: 18807150.
  • Ziedina I, Folkmane I, Chapenko S, Murovska M, Sultanova A, Jushinskis J, Rozental. Reactivation of BK virus in the early period after kidney transplantation. R. Transplant Proc. 2009 Mar;41(2):766-8. PMID: 19328975.
  • Chapenko S, Folkmane I, Ziedina I, Chistyakovs M, Rozentals R, Krumina A, Murovska M. Association of HHV-6 and HHV-7 reactivation with the development of chronic allograft nephropathy. Clin Virol. 2009;46:29-32. PMID: 19497784.
  • Mamaja B, Chapenko S, Donina S, Sultanova A, Murovska M. Changes of immunological status and activation of beta-herpesviruses in patients undergoing general or regional anaesthesia, Rīga Stradiņš University Collection of Scientific Papers 2008 “Research articles in medicine & pharmacy”, 2009:44-49.
  • Rivkina A, Lejniece S, Murovska M, Vitols G, Udre I. Levels of thymidin kinase in blood of primary patients with chronic lymphocytic leukaemia diagnosed in 2007. Rīga Stradiņš University Collection of Scientific Papers 2008 “Research articles in medicine & pharmacy”, 2009:80-82.
  • Rivkina A, Lejniece S, Murovska M, Udre I. ZAP-70, CD38 and beta-2-microglobulin in CLL patients, first diagnosed in 2007. Rīga Stradiņš University Collection of Scientific Papers 2008 “Research articles in medicine & pharmacy”, 2009:83-87.
  • Kozireva S, Chernobajeva L, Murovska M, Ozolanta I, Kasyanov V. Biocompatibility of natural and artificial vascular scaffolds in vitro and in vivo. Rīga Stradiņš University Collection of Scientific Papers 2008 “Research articles in medicine & pharmacy”, 2009:101-105.
  • Udre I, Lejniece S, Murovska M, Vitols G, Rivkina A. Levels of thymidine kinase in patients with newly diagnosed chronic myelogenous leukaemia in 2007. Rīga Stradiņš University Collection of Scientific Papers 2008 “Research articles in medicine & pharmacy”, 2009:106-109.
  • Kozireva S, Sultanova A, Kakurina N, Mikazane H, Lejnieks A, Murovska M. Serum IL-6, TNF-α, IL-1β and IFN-γ levels in rheumatoid arthritis patients with herpes virus type 6 (HHV-6) infection. Rīga Stradiņš University Collection of Scientific Papers 2008 “Research articles in medicine & pharmacy”, 2009:110-113.
  • Mačuks R, Eņģele L, Nuķe I, Doniņa S. Comparative analysis of insuline-like growth factor-I and tumor associated antigēns in cancer patients at the time of diagnosis. Proceedings of the Latvian Academy of Sciences. Sect B. Vol 63 2009. No. 4/5:20-30
  • Jaunalksne I, Doniņa S, Čapenko S, Čistjakovs M, Murovska. Cellular immunity in human herpes viruses 6 and 7 infected gastrointestinal cancer patients. M. Proceedings of the Latvian Academy of Sciences, Section B, Nr. 4/5, 2009:163-167
  • Kozireva S, Uzameckis D, Baryshev M, Murovska M. Sensitivity and reproducibility of PCR assays for detection of human herpesviruses 6 and 7 Proceedings of the Latvian Academy of Sciences, Section B, Nr. 4/5, 2009:180-185.
  • Kurjāne N, Brūvere R, Gabruševa N, Hagina E, Zvagule T, Jaunalksne I, Feldmane G, Volrāte Ā, Voskresenska N. Ageing and production of cytokines in Chernobyl clean –up workers from Latvia, Proceedings of Latvian academy of sciences, 2009;63;3:87-93.
  • Chapenko S, Orlova S, Sultanova A, Krumina A, Millers A, Logina I, Murovska M. HHV-6 and HHV-7 infection in chronic fatigue syndrome and multiple sclerosis patients. Contemporary problems of human infection pathology. The collection of scientific article , Issue 2. Minsk „FUAinform”, 2009:17-21
  • Donina S, Jaunalksne I, Chapenko S, Cistjakovs M, Murovska M. Cellular immunity in human herpesviruses 6 and 7 infected gastrointestinal cancer patients. Contemporary problems of human infection pathology. The collection of scientific articles , Issue 2. Minsk „FUAinform”, 2009:500-503
  • Mironov V, Kasyanov V, Nagy-Mehesz A, Moreno R, Hajdu Z, Trusk T, Ozolanta I, Murovska M, Wu Y, Yao H, Beachley V, Wen X, Bradshaw A, Visconti R, Norris R and Markwald R. Tissue engineering of heart valve leaflet by self-assembly of tissue spheroids biofabricated from human fat tissue derived stem cells. In: WC 2009, IFMBE Proceedings (Eds: O. Dossel and S. Schleger), 2009, vol.25:230-232.
  • Leja M, Bērziņš J, Doniņa S, Emziņš Dz, Eņģele L, Kojalo U u.c. Diagnostikas metožu izstrāde ļaundabīgu audzēju riska faktoru noteikšanai, agrīnai audzēju un pirmsvēža stāvokļu diagnostikai, audzēju terapijas optimizēšanaiLatvijas iedzīvotāju dzīvildzi un dzīves kvalitāti apdraudošās slimības zinātniskā analīze un galvenās rekomendācijas. (autoru kolektīvs Valda Pīrāga redakcijā), Rīga, 2009:43-56.

2008

  • Kozireva S, Zestkova J, Mikazane H, Kadisa A, Kakurina N, Lejnieks A, Danilane I, Murovska M . Incidence and clinical significance of parvovirus b19 infection in patients with rheumatoid arthritis.. J Rheumatol. 2008, 35(7): 1265-1270. PMID: 18484700.
  • Mamaja B, Chapenko S, Donina S, Sultanova A, Murovska M. Effect of general and regional anaesthesia upon major reconstructive surgery on beta-herpesviruses activation. Riga Stradiņš University Collection of Scientific Papers 2007, “Research articles in medicine & pharmacy “, 2008; 42-45.
  • Kozireva S, Donina S, Murovska M, Boka V. p15 promoter hypermethylation in serum DNA of patients with gastric carcinoma.. Riga Stradiņš University Collection of Scientific Papers 2007, “Research articles in medicine & pharmacy “, 2008: 80-83.
  • Kasyanov V, Hodde J, Hiles M.C, Eisenberg C, Eisenberg L, De Castro L.E.F, Ozolanta I., Murovska M., Draughn A.R, Prestwich G.D, Markwald R.R, Mironov V. Rapid biofabrication of tubular tissue constructs by centrifugal casting in a decellularized natural scaffold with laser-machined micropores. J Mater Sci: Mater Med DOI 10.1007/s10856-008-3590-3. PMID: 18807150.
  • Орлова С, Муровска М. Вирусные инфекции – возможные факторы развития синдрома хронической усталости. Сборник научных трудов «Современные проблемы инфекционной патологии человека», Выпуск 1, Министерство здравоохранения Республики Беларусь, Государственное учреждение «Научно-исследовательский институт эпидемиологии и микробиологии», Минск, «Белпринт», 2008:193-194.

2007

  • Kozireva S, Murovska M, Lejniece S, Kholodnyuk I. Chemokine receptor’s genes expression in T-cell lines driven from patients with hematological malignancies. Scientific Papers University of Latvia, Vol. 712, Medicine, 2007: 7-12.
  • Bernarde K, Folkmane I, Chapenko S, Murovska M, Rozentals R. The impact of early cytomegalovirus (CMV) infection and CMV disease on long-term kidney allograft function and late complications after kidney transplantation: a clinical study. Scientific Papers University of Latvia, Vol. 712, Medicine, 2007: 13-19.
  • Kost Alimova M, Darai-Ramquist E, Yau WL, Sandlund A, Fedorova L, Yang Y, Kholodnyk I, Cheng Y, Li Lung M, Stanbridge E, Klein G, Imreh S. Mandatory chromosomal segment balance in aneuploid tumor cells. BMC Cancer, 2007 Jan., 26:7-21.
  • Ramniece V, Nikolajevs V. Lactobacillus helveticus strain R-7-liquid starter for the production of natural-set fermented dairy products. Chemine technologia, 2007, N 4 (46): 48-52.
  • Bratslavska O, Platace D, Miklaševičs E, Martinsons A. Influence of neopterin and 7,8-dihydroneopterin on the replication of Coxsackie type B5 and influenza A viruses. Medical Microbiology and Immunology, 2007:196 (1): 23-29
  • Муровска M, Чапенко C, Козырева C, Султанова A, Дониня C, Фолкмане И, Круминя A, Лейниеце C, Лейниекс A. Бета-герпесвирусы чеповека (ВГЧ-6, ВГЧ-7), их распространение и ассоциация с патологическими процессами. Материалы Международной научно-практической конференции Вирусные инфекции: эпидемиология, клиника, лабораторная диагностика и профилактика. Минск, Государственное учреждение «НИИ эпидемиологии и микробиологии», 29-30 ноября 2007: 93-96.

2006

  • Kholodnyuk ID, Kozireva S, Kost-Alimova H, Kashuba V, Klien G, Imreh S. Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromoseme 3-mouse fibrosarcoma hybrids in severe combinated immunodeficiency mice. Int.J.Cancer, 2006:119:99-107. PMID: 16432833.
  • Bratslavska O, Platace D, Miklaševičs E, Fuchs D, Martinsons A. A influence of neopterin and 7,8-dihydroneopterin on replication of Coxsackie type B5 and influenza A viruses. Medical Microbiology and Immunology, 2006. PMID: 16868770.
  • Kasyanov V, Isenburg J, Draughn RA, Hazard S, Hodde J, Ozolanta I, Murovska M, Halkes SB, Vrasidas I, Liskamp RM, Pieters RJ, Simionescu D, Markwald RR, Mironov V. Tannic acid mimicking dendrimers as small intestine submucosa stabilizing nanomordants. Biomaterials, 2006, 27(5): 745-751. PMID: 16102811.
  • Chapenko S, Krumina A, Kozireva S, Nora Z, Sultanova A, Viksna L, Murovska M. Activation of human herpesviruses 6 and 7 in patients with chronic fatigue syndrome. J. Clin. Virol Suppl., 2006:47-51. PMID: 17276369.
  • Folkmane I, Bernarde K, Chapenko S, Kozireva S, Zezina L, Murovska M, Rozental R. Anemia in renal transplant patients caused by parvovirus B19 infection. World Transplant Congress. The First Joint International Transplant Meeting. Boston, Massachusetts. Suppl. to American Journal of Transplantation and Transplantation, July 22-27, 2006:150.
  • Logina I, Nora Z, Chapenko S, Dzelzite S, Murovska M. Implication of human herpesviruses in spine disorders. 5th Congress of the European Federation of IASP Chapters (EFIC) “Pain in Europe V”. Istanbul, Turkey, September 13-16, 2006. European J Pain, 2006:107.
  • Lisagors I, Sondore A, Ošs P, Pavārs M, Jaunalksne I, Skesters A, Silova A, Zamerovska A, Krutskiha V, Eklona A, Porina I, Bushujeva M, Jaunberga Z. The role of hyperbaric oxygenation as an adjunctive therapeutic method in the treatment of severe acute pancreatitis.A case report. European Journal of Underwater And Hyperbaric Medicine, 2006, 7: 3.66.

Intellectual property

  • Patent LV 14595 B. A method of creating a spatially arranged cell structure using viable cells of a grown-up human organism/Vladimirs Kozlovs, Andrejs Karpovs, Viktorija Priedīte, Dace Avotiņa, Pēteris Stradiņš, Mārtiņš Kalējs, Vladimirs Kasjanovs, Vladimirs Mironovs; owner — Riga Stradiņš University. Patent publication date: 20.02.2013. Application No. P-12-78 (LV), application date: 17.05.2012, date of the application’s publication: 20.10.2012.

  • Pat. LV 14500 B. A food supplement with antiviral, anti-cancer, hepatoprotective and immunomodulative qualities / Guntis Vītols, Lilija Peškova, Jevgeņijs Jermolajevs; owner — Riga Stradiņš university, Ltd. “Anima Lab”. Patent publication date: 20.11.2012. Application No. P-11-173 (LV), application date: 21.12.2011, date of the application’s publication: 20.04.2012.

  • Patent LV 14505 B. A composition of glycopeptides educed from Lactobacillus helveticus, and the method of its acquisition/Guntis Vītols, Lilija Peškova, Jevgeņijs Jermolajevs; owner - Riga Stradiņš university, Ltd. “Anima Lab”. Patent publication date: 20.12.2012. Application No. P-11-170 (LV), application date: 07.12.2011, date of the application’s publication: 20.04.2012.

  • Patent LV 13296 B. R-7 strain of the lactic acid bacteria Lactobaccilus helveticus — a quick-working milk (low-fat milk) fermenter and improver of the taste and consistency of acidified milk products/Vija Ramniece; owner — Vija Ramniece. Patent publication date: 20.07.2005; application No. P-05-09 (LV), application date 31.01.2005, date of the application’s publication: 20.05.2005.

Doctoral Thesis

2012

2011

2008

  • Zaiga Nora: The association between herpes viruses and demyelinating and non- demyelinating diseases of the central and peripheral nervous system. Supervisor: Modra Murovska

Accomplishments

The following products have been introduced to the market:

  • Rigvir
  • Larifans
  • Labdaris
  • Glikomuns

mikrobio-vir-inst-btm


Rīga Stradiņš University, 16 Dzirciema Street, Rīga, LV-1007, Latvia, +371 67409261 (UTC +2), international@rsu.lv