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Projects

Grants by the Latvian Council of Science

  • Collaboration programmes of the Latvian Council of Science: No. 09.1402. “Specific, immunogenetics, biochemical, clinical, radiological differential diagnosis of acute and chronic borreliosis (Lyme disease), projections of the course of the disease, patient life quality verification for the prophylaxis of disability caused by borreliosis and reduction of the burden on the health of the society in Latvia.” Duration: 2009–2012

  • Collaboration programmes of the Latvian Council of Science: No. 10.0029 “Innovative approaches in the research of molecular-genetic features of micro-organisms and systematic damage mechanisms related to it, as well as in the elaboration of individual infectious disease supervision, diagnostics and therapy methods and techniques” (leading prof. L. Vīksna) in sub-project: No. 10.0029.5. “MHC/HLA genes and the role thereof in the etiopathogenesis; genetic forecast of disease progress and therapy efficiency”. Duration: 2010–2013

  • Collaboration programmes of the Latvian Council of Science: No. 10.0010.09. “Chromosome 6p21.3 MHC/HLA region genotyping and immunoregulatory gene nucleotide sequence of the second exon and prognostic criteria determination in the case of HIV infection.” Duration: 2010–2013

  • Project of the Latvian Council of Science: No. 09.1604. “Specific, immunogenetics, biochemical, clinical, radiological differential diagnosis of acute and chronic borreliosis (Lyme disease), projections of the course of the disease, patient life quality verification for the prophylaxis of disability caused by borreliosis and reduction of the burden on the health of the society in Latvia.” Duration: 2009–2012

Projects financed by other international institutions

  • COST programme: No. BM0803 “A European network of the HLA diversity for histocompatibility, clinical transplantation, epidemiology and population genetics (HLA-NET)” Duration: 2009–2013

Publications

2016

Z. Dāvidsone, J. Eglīte, A. Lazareva, S.Dzelzīte, R. Šantere, D. Bērziņa, V. Staņēviča HLA II class alleles in juvenile idiopathic arthritis patients with and without temporomandibular joint arthritis. Pediatr Rheumatol Online J. 2016 Apr 19;14(1):24. doi: 10.1186/s12969-016-0086-4.

J. Eglite, I. Golushko, E. Urtans, I. Januskevica and B. Rozentale. Association of Tumor Necrosis Factor-α (TNFα) Gene Polymorphisms with HLA Class II Alleles in HIV/AIDS Patients British Journal of Medicine & Medical Research 13(12): 1-10, 2016.,NLM ID 101570965.

I. Januškevica, B. Rozentāle, E.Hagina, J. Eglīte, T. Kolupajeva, J. Storozenko, L. Guseva, and Aivars Lejnieks. Role of Interferon-Gamma (IFN-y) in immune response regulation in HIV-1 and HIV-1 + mycobacterium tuberculosis (TB) infected patients. Proceeding of Latvian Academy of Sciences. Section B, Vol. 70 (2016), pp. 211-214.

I.Januskeviča, A.Sangirejeva, J.Eglīte, E.Hagina, V.Jasinskis, J.Storozenko, A.Lejnieks and B.Rozentale. Trends in Tuberculosis/Human Immunodeficiency Virus Comorbidity, Latvia, 2012-2014. Journal of Scientific Research& Reports 9(5):1-7,2016;DOI: 10.9734/JSRR/2016/22247.

L.Kovalchuka, S.Cvetkova, J.Trofimova, J. Eglite, S.Gintere, I.Lucenko, B.Oczko-Grzesik, L. Vīksna, and A. Krumina. Immunogenetic Markers Definition in Latvian Patients with Lyme Borreliosis and Lyme Neuroborreliosis. International Journal of Environmental Research and Public Health 2016, 13, 1194; doi:10.3390/ijerph13121194. 

L.Kovaļčuka, J.Eglite, M.Zālīte, I.Lucenko, L.Vīksna and A.Krūmiņa. Immunogenetic manifestations of lyme borreliosis . Proceeding of Latvian Academy of Sciences. Section B, Vol. 70 (2016), pp. 215-219.

I. Januskevica, Baiba Rozentāle, Elvīra Hagina, Jelena Eglīte, Tatjana Kolupajeva, Jelena Storozenko, Ludmila Guseva, Aivars Lejnieks. Role of Interferon-Gamma in immune response regulation HIV and HIV + TBC infected patients. RSU Zinātniskās konferences tēzes, 17-18.03.2016. g. 143 .lpp. 6.

L.Vainsteine, G. Gulbe, L.Kovalchka, G. Karelis, J.Eglite, V. Kenina, A.Krumina. Gene HLA DRB1 alleles characterization of MS patients in Latvian population. 2ND Congress of the European Academy of neurology 2016. Copenhagen, P 31161.

L.Vainsteine, G. Gulbe, L.Kovalchka, G. Karelis, J.Eglite, V. Kenina, A.Krumina. Immune-genetic Characterisation of Multiple Sclerosis Patients in Latvian Population. RSU Zinātniskās konferences tēzes. 17.-18.03.2016. g., 115.lpp.

2015

I. Januškeviča, A.Sangirejeva, J.Eglīte, E.Hagina, V.Jasinskis, J.Storozenko, A.Lejnieks and B.Rozentale. Trends in Tuberculosis/Human Immunodeficiency Virus Comorbidity, Latvia, 2012.-2014. Journal of Scientific Research& Reports 9(5):1-7, 2016. Article no JSRR.22247 ISSN:2320-0227.

V. Jasinskis, D. Kasjko, J. Eglite, G. Sture, L. Viksna. Regulatory Role of HLA DR/DQ II Classes Haplotypes in the TNFα, Activity Response in HIV/AIDS Patients, RSU Zinātniskās konferences tēzes. 26.-27. 03. 2015. g., 197. lpp.

D.Kasjko, V.Jasinskis, J.Eglīte. Identification of TNFa, alleles,genotype and risk genes in HIV/AIDS patients. World immune regulation meeting IX 2015, Davos, Switzerland Abstracts, PQ40, 60 lpp.

L.Kovaļčuka, J.Eglīte, I. Lucenko, I.Logina, M.Zālīte, L.Vīksna, A.Krūmiņa. Distribution of MHC-DQ Haplotypes in Patients with Lyme Disease. RSU Zinātniskās konferences tēzes 26.-27. 03. 2015. g ,113 lpp.

S. Laivacuma , Jelena Eglite , Aleksejs Derovs , Ludmila Viksna . Chrarac teristics and HL A II class polymorphism in patients with alveolar echinococc osis in La tvia. Collection of Scientific Papers 2015 Abstracts from VII Latvian Gastroenterology Congress with International participation Research articles in medicine & pharmacy, 2015 Supplement I 87p

A. Lazareva, J. Eglīte, S. Zadoroznijs, Z.Davidsone, R.Santere, D. Berzina, V.Stanevicha. IL-6, IL-1A and TNF-A gene polimorphism in children with Juvenile Idiopathic Arthritis. Ann Rheum Dis 2015;74:964 doi:10.1136/annrheumdis-2015-eular.5662, 964 lpp.

L.Vainsteine, L.Kovalcuka, G.Gulbe, T. Sidorcika, G.Karelis, V.Kenina, A.Krumiņa, J.Eglite. Multiple Sclerosis Immune-genetic Characterization in Patients of Latvian Population. RSU Zinātniskās konferences tēzes 26.-27. 03. 2015. g. 114. lpp.

2014

Z. Davidsone, E.Eglite, S.Dzelzīte,A.Lazareva, R.Santere, D.Berzina. V.Stanevicha. HLA II class alleles in juvenile idiopathic arthritis patients with temporomandibular joint involvement. Pediatric Rheumatology 2014., Volume 12., (1 Suppl), Poster 24, PP 29.

J. Eglite, M. Zalite, I. Lucenko, I. Logina, G. Karelis, L. Viksna, A. Krumina and L. Kovaļčuka. Allelic Distribution of Human Leukocyte Antigen in Latvian Patients with Tick- Borne Diseases. October 28.-30.2014. Boston, USA, Poster No 6, PP 5.

E.Eglite, D.Kasjko,V.Jasinskis, G.Sture, L.Viksna A.Sochnevs, The HLA class II genotypes associated with sustained response to antiretroviral therapy (ART) in patients of AIDS. The 11th Annual conference of the Baltic Network against Life-Threatening Viral Infections, Vilnius, Lithuania, April 24.-27.2014. Abstract No 35. , 93 – 94 pp.

E. Eglite, E. Hagina, J. Pavare, I. Grope, L. Eihvalde, A. Sochnevs and D. Gardovska. Genetic Polymorphisms HLA Class II in SIRS and Sepsis in Children. British Journal of Medicine and Medical Research. 4(1):149-160. 2014.

V. Jasinskis, D. Kasjko , E. Eglite, G.Sture , L.Viksna, B. Rozentale, A. Sochnevs, Comparison of Antiretroviral Therapy (ART) Efficiency and Different HLA Class II Haplotypes, British Journal of Medicine & Medical Research 4(7): 1473-1482. March, 2014.

D.Kasjko,V.Jasinskis, E.Eglite, A.Sochnevs, G.Sture, L.Viksna. The HLA class II molecules play a central role in regulating the immune response of HIV- infected patients in AIDS stage. The 11th Annual conference of the Baltic Network against Life-Threatening Viral Infections, abstract No 36. Pub. date: April 24.-27.,2014.,95-96 pp,Vilnius, Lithuania.

D. Kasjko, V. Jasinskis, E. Eglite, L. Kovalchuka,Elina Dobele, G. Sture, A. Sochnevs, and L. Viksna. Mutations in HLA DRB1*0101 Exon 2 in a Sub-population of Latvia. British Journal of Medicine & Medical Research 4(4): 981-989. 2014.

D. Kasjko, V. Jasinskis , E. Eglite, J.Golushko, G. Sture, A. Kalimulin, A. Sochnevs, and L. Viksna. Research of HLA II class DRB1, DQA1, DQB1 genetic markers in patients with HIV infection and AIDS. British Journal of Medicine & Medical Research 4(27): 4482-4500, 2014.

V. Kenina, A. Iljina, E. Hagina, N. Kurjane. Antinuclear autoantibodies in patients with positive paraneoplastic antibodies: clinical and immunological data. University-Tartu, Tallin, Estonia, 23.04.-26.04.2014. g. 42 pp.

L. Kovalchuka, J.Eglite, T. Sidorcika, M. Zalite, G. Karelis, I. Logina, A. Krumina, L. Viksna. Detection Human Leukocyte Antigen Haplotypes in Latvian Patients with TBE. Tisue antigen, Vol.84, Number 1, July 2014, PP148.

L. Kovalchuka, J. Eglite, M. Zalite, I.Lucenko, I. Logina, G. Karelis, L. Viksna, A. Krumiņa. The frequency of HLA-DR alleles in patients with Tick-borne disease from Latvia. Res J Infect Dis 2014. ISSN:2052-5958. Volume 2, Article 4, doi: 10.7243/2052-5958-2-4.

L. Kovalchuka, J. Eglite, I. Lucenko, I. Logina, M.Zalite, L.Viksna, A. Krumina. Haplotype HLA-DQ frequency distribution in Latvian patients with Lyme disease”. (GDRI 2014) From Molecular to Cellular Events in Human Pathologies. October 17.-20. University of Latvia, Journal Biopolymers and Cell, Volume 30, Number 5, PP 22.

L. Kovalchuka, J.Eglite, T. Sidorcika, A. Krumina G. Karelis, Gene HLA DRB1* Polymorphism Characterization in Latvian TBE Patients., RSU Zinātniskās konferences tēzes, 10.-11.04.2014. g. 216.lpp.

L. Kovalchuka, J. Eglite, M. Zalite, S. Gintere, L.Viksna, A. Krumiņa. Molecular Genetic Characteristic Patients with Borrelia Burgdorferi Infection. RSU Zinātniskās konferences tēzes, 10.-11.04.2014.g. 196.lpp.

A. Krumina, G. Vasiljeva, A. Ivanovs, S. Gintere, L. Kovalchuka, S. Rasa, S. Chapenko, M. Murovska, L.Viksna and I. Logina. Assessment of Value of Fatigue Severity and Symptoms in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Fibromyalgia. British Journal of Medicine & Medical Research 4(36): 5866-5877, 2014. ISSN:2231-0614. Pub. date: 26.august 2014.

L.Viksna, A. Jeruma, J.Eglite, A.Sočņevs, and V.Sondore. Biochemical and Immunogenetic Diagnostic Markers Less Commonly Used for Predicting the Efficacy of Chronic Hepatitic C Etiotropic.Therapy.Virology&Mycology,ISSN:2161-0517 VMID, an open access journal. Pub. date: May 08, 2014.

2013

  • Kasjko, D., Eglite, E., Jasinskis , V., Sture, G., Sochnevs, A., Viksna, V., Glushko, J., Kalimulin, A. Research of HLA II class DRB1, DQA1, DQB1 genetic markers in patients with HIV infection and AIDS. British Journal of Medicine & Medical Research 2013, 27, December (in press)
  • Jasinskis, V., Kasjko, D., Eglite, E., Sture, G.,Viksna, L., Rozentale, B. Comparison of Antiretroviral Therapy (ART) Efficiency and Different HLA Class II Haplotypes. British Journal of Medicine & Medical Research 4(7): 1473-1482, (in press)
  • Eglite, E., Hagina, E., Pavare, J., Grope, I.,  Eihvalde, L., Sochnevs, A.,  Gardovska., D. Genetic Polymorphisms HLA Class II in SIRS and Sepsis in Children// British Journal of Medicine & Medical Research 4(1): 149-160 (in press)
  • Kasjko, D., Jasinskis, V., Eglite, J., Dobele, E., Kovalchuka, L., Viksna, L., Sture, G.,  Rozentale, B., Sochnevs, A.// Mutations in HLA DRB1*0101 Exon 2 in a sub-population from Latvia// British Journal of Medicine and Medical Research. 2013_BJMMR5660 (in press)
  • Kovalchuka, L., Eglite, J., Zalite, M., Lucenko, I., Logina, I., Karelis, G., Viksna, L., Krumiņa, A. HLA-DR alleles in patients from Latvia: markers for Tick-borne diseases susceptibility and resistance. BMC Infectology Diseases. 2013. (in press)

2012

  • Eglite J, Sochnevs A, Kovalchuka L, Kasjko D, Viksna L, Sture G. Genetic polymorphisms Human Leukocyte Antigen class II haplotypes in HIV infected patients. Tissue antigens Immune response genetic number 6 june 2012, 79(6), pp. 573-573, 2012.
  • Kurjane N., Eglite J., Tolpak N., Debeljak M., Avcin T.: The first case of familial Mediterranean fever diagnosed in Latvia. J. Clin. Immunol. Vol. 32 Suppl. 1, pp. 117-117, 2012.
  • Kovalchuka L., Eglite J., Lucenko I., Zalite M., Viksna L., Krumina A.: Associations of HLA DR and DQ molecules with Lyme borreliosis in Latvian patients, BMC Res Notes. 5(Aug 14), pp. 438, 2012, doi: 10.1186/1756-0500-5-438.
  • Sanchez-Mazas, A., Vidan-Jeras, B., Nunes, J.M., Fischer, G., Little, A.-M., Bekmane, U., Buhler, S., E.Eglite, Tiercy, J.-M. Strategies to work with HLA data in human populations for histocompatibility, clinical transplantation, epidemiology and population genetics: HLA-NET methodological recommendations Int J Immunogenet. 2012. doi: 10.1111/j.1744-313X.2012.01113x.
  • Viksna, L. Sondare, V., Keiss, J., Jeruma, A., Prieditis, P., Strumfa, I., Sochnevs, A., Eglite, J., Rozentale, B. Noninvasive alternatives of liver biopsy. InTech, „Liver biopsy book” ISBN 978-953-307-644-7, 2012.

2011

  • Eglīte, J., Kovalčuka, L., Kasjko, D., Stūre, G., Bekmane, U., Sočņevs, A., Vīksna, L. HLA-DRB1*0101 2 exon structure polymorphism’s study in-patients with HIV/AIDS” Journal of Antivirals & Antiretrovirals, Journal of AIDS & Clinical Research USA. ISSN:1948-5964, p. 227, 2011.

2010

  • Stanevicha, V., Eglite, J., Zavadska, D., Sochnevs, A., Lazareva, A., Guseinova, D., Shantere, R., Gardovska, D.: HLA B27 allele types in homogeneous groups of juvenile idiopathic arthritis patients in Latvia. Pediatr. Rheumatol. Vol. 8, 2010.
  • Kovalchuk, L., Eglite, E, Zeltina, I., Viksna, L., Sochnevs, A.: Investigation of HLA-DRB1 Genes in Tick-Borne Encephalitis Patients in Latvia. Scand. J. Immunol. Vol. 71, pp. 535 - 535, 2010.
  • Mazas, S., Bekmane, U., Buhler, S., Buus, S., Dormois, A., Dubois, V., Eberhard, H.P., Eglite, J. and et. al. HLA-NET, an EU-funded Network of research on HLA Diversity. EFIs Congress Florence, EFI 2010-444, 2010.
  • Eglite, E., Sochnev, A., Viksna, L. HLA - DRB1*0101 exon 2 structure polymorphism’s study in-patients with HIV/AIDS. EFIs Congress Florence, EFI2010-489, 2010.
  • Kovalchuka, L., Eglite, E., Zeltina, I., Viksna, L., Sochnevs, A. Investigation of HLA – DRB1 Genes in Tick Borne Encephalitis Patients in Latvia, Scandinavian journal of Immunology Nr.6.vol.71. p.-118, 2010.
  • Prokofjeva, T., Shantere, R., Teivane, E., Bergmane, I., Kovalchuka, L., Hagina, E., Jaunalksne, I., Stanevicha, V. Clinical and Immunological Findings in Children with Neonatal Lupus Erythematosus in Latvia. Scandinavian journal of Immunology Nr.6.vol.71. PS-032.lpp., 2010.
  • Kovalchuka, L., Eglite, J., Zeltina, I., Viksna, L., Sochnevs, A. Investigation of HLA – DRB1 Genes in Tick Borne Encephalitis Patients in Latvia, Scandinavian journal of Immunology nr.6.vol.71. PS-118.lpp., 2010.

2009

  • Kurjāne, N., Brūvere, R., Gabruševa, N., Hagina, E., Zvagule, T., Jaunalksne, I., Feldmane, G, Volrate, Ā., Voskresenska, N. Ageing and production of the cytokines in Chernobyl clean-up workers from Latvia. //Proceedings of the Latvian Academy of Sciences, Vol.63 (3), 87-92, 2009.
  • Vīksna, L., Keišs, J., Sočņevs, J., Rozentāle, B., Pilmane, M., Sevastjanova, N., Buiķe, I., Jēruma, A., Eglīte, J., Ābeltiņa, K., Sondore,V. Novel Laboratory Tests in Assessment of Liver Function in Acute and Chronic Viral Liver Diseases Proceeding of the Latvian Academy of Sciences, Vol.63, numb.4/5, pp 228-233. lpp., 2009.

2008

  • Simanis, R., Lejniece, S., Sochnevs, A., Eglite, J., Chernevska, G., Kovalova, Z., Gardovska, D., Jeruma, A., Kuse, V., Viksna, L. Natural clearance of hepatitis C virus in hemophilia patients. Med. Lith. Vol. 44, pp. 15 - 21, 2008

2007

  • Zavadska, D., Stanevicha, V., Eglite, J., Sochnevs, A., Gardovska, D., Shantere, R.: HLA Class II DR and DQ genotypes and haplotypes associated with rheumatic heart disease among clinically homogeneous patients in children in Latvia. Joint Bone Spine Vol. 74, pp. 218 - 219, 2007
  • Guseinova, D., Stanevicha, V., Eglite, J., Sochnevs, A., Shantere, R., Berzina, D., Schegolevs, A.: HLA I class B 27 antigen subtypes in children with Juvenile Idiopathic Arthritis in Latvia. Joint Bone Spine Vol. 74, pp. 220 - 220, 2007
  • Stanevicha, V., Eglite, J., Zavadska, D., Sochnevs, A., Shantere, R., Gardovska, D.: HLA class II DR and DQ genotypes and haplotypes associated with rheumatic fever among a clinically homogeneous patient population of Latvian children. Arthritis Res. Ther. Vol. 9, 2007.
  • Simanis, R., Eglite, J., Lejniece, S., Viksna, L., Sochnevs, A. Natural clearance of hepatitis C virus infection and Human Leucocyte Antigen Class II alleles in children with Haemophilia, XXIst Congress of the International Society on Thrombosis and Haemostasis, Geneva, abstracts number is: P-T-137, 2007.
  • Simanis, R., Jeruma, A., Eglite, J., Kovalova, Z., Gardovska, D., Lejniece, S., Viksna, L., Sochnevs, A. Blugers, A. Natural clearance of hepatitis C virus infection and Human Leucocyte Antigen Class II genes. 17th Asian Pacific Association for the study of Liver Conference (APASL 2007) Kyoto, Japan Hepatology International, 1:135 lpp., 2007.
  • Eglīte, E., Kovaļčuka, L., Bekmane, U., Sočņevs, A., Stūre, G., Vīksna, L., Rozentāle, B. Human Leukocyte Antigens (HLA) II Class and Acquired Immune Deficiency Syndrome (AIDS) Disease Progression. Proceedings of The Latvian Academy of Sciences, vol.61, No.5, abstract book - pg. 165. 2007.
  • Marga, M., Sochnevs, A., Pirags, V., Farid, N.R. The impact of the HLA MHC Class II Genes and Haplotypes on the Susceptibility and Natural Course of Graves‘ Disease. The Endocrine Society’s 89th Annual Meeting, abstract #853421 Preview, page 2., 2007.

2006

  • Kovalchuk L., Sochnevs A., Prokofjeva T., Nekiforenko E., Priedite V., Jaunalksne I. HLA-DRB1 Friquency for patients with Selective Immunoglobulin A Deficiency in Latvia. 8th Baltic Congress of Laboratory Medicine – Vilnius 2006, Lithuania, may 18-20, 2006, “Laboratorinė Medicina” abstract book, Nr.1(129) p32., 2006.
  • Rezeberga, D., Lazdane, G., Kroica, J., Sokolova, L., Sochnev, A., Donders, G.G. Reproductive tract infections in low-risk pregnant women in Latvia. The 19th European Congress of Obstetrics and Gynaecology, Torino, Italy, abstract book, 2006.

Doctoral Thesis

2011

Intellectual property

  • Patent LV 14106 B. Means for the treatment of juvenile idiopathic arthritis (JIA)/Valda Staneviča, Jeļena Eglīte, Ruta Šantere, Arina Lazareva, Lilija Kovaļčuka, Artūrs Sočņevs, Dace Gardovska. Owners: Riga Stradiņš University, Valda Staņēviča. Application date: 14.12.2009. Application number: P-09-223, patent publication date: 20.02.2010.

  • Patent LV 14066 B. Systemic inflammatory response syndrome (SIRS) development forecast type for newborns and children/Dace Gardovska, Artūrs Sočņevs, Jeļena Eglīte, Jana Pavāre, Ilze Grope. Owners: Riga Stradiņš University, Dace Gardovska. Application date: 24.03.2009. Application number: P-09-59, patent publication date: 20.03.2010.

Accomplishments

  • Introduction of new tests in clinical practice (predisponed with Coeliac disease, diabetes, arthritis, asthma, infertility, etc.)

  • Introduction of new molecular methods in the practical work of the laboratory (PCR; RT-PCR; PCR-SSP; Real-Time qRT-PCR)

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