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Grants by the Latvian Council of Science and public-private partnerships

  • Latvian Council of Sciences grant No. 09.1383. “Research of biomechanical properties and biocompatibility of new nanostructured and composite biomaterial for application in cardiovascular surgery”. Duration: 2009–2012

  • Public-private partnership “Development of New Preventive, Treatment, Diagnostic Means and Methods, Biomedical Technologies for Improvement of Public Health”, sub-project “Studies of biomaterials for treating cardiovascular diseases”. Duration: 2010–2013

EU Structural Funds and INTERREG projects

  • European Social Fund activity “Attraction of Human Resources to Science” project “New interbranch group to develop nanotechnology-based approaches to cell biology with medical application”, No. 2009/0221/1DP/ Duration: 2010-2012

Projects financed by other international institutions

  • NATO funded international project “Vascular Tissue Engineering by Fusion of Self-Assembling Cell Aggregates” (partners from the USA and Spain). Duration: 2004–2005



  • Vladimir Kasyanov, Ricardo Moreno-Rodriguez, Martins Kalejs, Iveta Ozolanta, Peteris Stradins, Xuejun Wen, Hai Yao, Vladimir Mironov. Age related analysis of structural, biochemical and mechanical properties of the porcine mitral heart valve leaflets. Connective Tissue Research, 2013, 54(6), p. 394 – 402.

  • Martins Kalejs, Romans Lacis, Vladimir Kasyanov, Iveta Ozolanta, Philippe Abdel Sayed, Peteris Stradins and Ludwig Karl von Segesser. Comparison of radial deformability of stent posts of different aortic bioprostheses. Interactive CardioVascular and Thoracic Surgery, 2013, 16, p. 129 – 133.

  • N. Sikora, A. Lacis, V. Kasyanov, V. Groma, E. Ligere, V. Ozolins and L. Smits. The proper delivery pressure for cardioplegic solution in neonatal cardiac surgery – an investigation of biomechanical and structural properties of neonatal and adult coronary arteries. Perfusion, 2013, 28(4), p. 357 – 367.

  • Rezende, R.A., Pereira, F.D.A.S., Kasyanov, V., Kemmoku, D.T., Maia, I., Da Silva, J.V.L., Mironov, V. Scalable biofabrication of tissue spheroids for organ printing. Procedia CIRP 5, 2013, pp. 276 – 281.

  • Rezende, R.A., Kasyanov, V., Ozolanta, I., Brakke, K., da Silva, J.V.L., Mironov, V. Design of vascular tree for organ bioprinting. Computer Aided Chemical Engineering, 2013, 32, pp. 151 – 156.

  • R. A. Rezende, S. V. Selishchev, V. A. Kasyanov, J. V. L. da Silva, and V. A. Mironov. An Organ Biofabrication Line: Enabling Technology for Organ Printing. Part I: from Biocad to Biofabricators of Spheroids. Biomedical Engineering, 2013, 47, 3, 2013, p. 116 – 120.

  • R. A. Rezende, S. V. Selishchev, V. A. Kasyanov, J. V. L. da Silva, and V. A. Mironov. An Organ Biofabrication Line: Enabling Technology for Organ Printing. Part II: from Encapsulators to Biofabrication Line. Biomedical Engineering, 2013, 47, 4, 2013, p. 213 – 218.

  • Vladimir Mironov, Rodrigo A. Rezende, Vladimir Kasyanov, Jorge V. L. da Silva. Virtual Biofabrication Line. In: IFAC Proceeding Volumes (IFAC – PapersOnline) of 6th IFAC Conference on Management and Control of Production and Logistics (PART 1), Fortaleza, Ceará, Brazil, 2013, September 11-13, p. 289 – 294.

  • Peteris Stradins, Martins Kalejs, Viktorija Priedite, Romans Lacis, Iveta Ozolanta, Modra Murovska and Vladimir Kasyanov. Fibroblast Growth on Nanofiber Material Matrices and Changes to Their Mechanical Properties. International Journal of Materials, Mechanics and Manufacturing, 2013, 1, 4, p. 328 – 321.

  • Martins Kalejs, Peteris Stradins, Romans Lacis, Iveta Ozolanta, Modra Murovska, Vladimir Kasyanov. Search For Electrospun Nanofiber Materials Matching The Mechanical Properties Of Native Aortic Valve. In: Proceeding of 2013 International Conference on Nano and Materials Engineering (ICNME 2013), 8 – 9 April 2013, Bangkok, Thailand, 4 p.


  • Kalejs M, Lacis R, Kasyanov V, Ozolanta I, Abdel Sayed P, Stradins P, Von Segesser LK. Comparison o fradial deformability of stent posts of different aortic bioprostheses. Interact Cardiovasc Thorac Surg., p. 1-5, 2012

  • Sikora, N., Lācis, A., Teivāne, E., Ozoliņš, V., Šmits, L., Bergmane, I., Kasyanov, V. Biomechanical Properties of Coronary Arteries Neonates: Preliminary Results. Analysis and design of biological materials and structures. In: Analysis and design of biological materials and structure. Advanced Structured Materials (Eds. A. Ochsneretal.), Springer-Verlag, Volume 14, Part 2, 111 – 124, DOI: 10. 1007/978-3-642-22131-6_9, 2012

  • Ligere, E., Sikora, N., Ozolins, V. Smits, L., Bergmane, I., Lacis, A.,Kasyanov, V. Biomechanical properties of the aorta in neonates and infants. In: Analysis and design of biological materials and structure. Advanced StructuredMaterials (Eds. A. Ochsneretal.), Volume 14, Part 2, 125-132, Springer-Verlag DOI: 10. 1007/978-3-642-22131-6_10, 2012

  • Eina Ligere, Valts Ozolins, Lauris Smits, Normubds Sikora, Ivars Melderis, Laila Feldmane, Aris Lacis, Vladimir Kasyanov. The Biomechanical properties of the different modalities of surgically corrected coarctation of the aorta in neonates and infants. World Academy of Science, Engineering and Technology, 66, p. 60-63, 2012

  • Rezende R., Pereira F., Kasyanov V., Ovsianikov V., Torgensen J., Stampfl J., Nogueira J., Mironov V., Silva J.: Design, physical prototyping and initial characterization of lockyballs: enabling technological platform for bottom-upmodular 3D tissue biofabrication. Virtual and Physical Prototyping, 7, 4, p. 287-301, 2012

  • R.A. Rezende, F.D.A.S. Pereira, V. Kasyanov, D.T. Kemmoku, I. Maia, J.V.L. da Silva, V. Mironov. Scalable biofabrication of tissue spheroids for organ Printing., Procedia CIRP, 6 p., 2012

  • Rezende, R.A., Azevedo, F.D.S., Pereira, F.D., Kasyanov, V., Wen, X., De Silva, J.V.L., Mironov, V.: Nanotechnological strategies for biofabrication of human organs, Journal of Nanotechnology. Article ID 149264, 10 p, 2012


  • Mironov, V., Kasyanov, V., Markwald, R.R.: Organprinting: From bioprinter to organ biofabrication line. Current Opinionin Biotechnology Vol. 22, pp. 667 - 673, 2011

  • Kasyanov, V., Brakke, K., Vilbrandt, T., Moreno-Rodriguez, R., Nagy-Mehesz, A., Visconti, R., Markwald, R., Ozolanta, I., Rezende, R.A., Filho, A.L., Neto, P.I., Pereira, F.D.A.S., Kemmoku, D.T., da Silva, J.V.L., Mironov, V.: Toward organ printing: Design characteristics, virtual modelling and physical prototyping vascular segments of kidney arterial tree: This paper highlights the main issues regarding design characteristics, virtual modeling and physical prototyping of vascu. Virtual and Physical Prototyping Vol. 6, pp. 197 - 213, 2011

  • Rezende, RA, Mironov, V, Kasyanov, V, Maciel, R, da Silva, JVL: Rational design for irrigation dripping tripled perfusion bioreactor. Int. J. Artif. OrgansVol. 34, pp. 687 - 687, 2011

  • Mironov, V, Mehesz, AN, Rezende, RA, Pereira, FDAS, Kasyanov, V, da Silva, JVL: Scalable biofabrication of uniformed sized tissue spheroids for organ printing. Int. J. Artif. OrgansVol. 34, pp. 687 - 687, 2011

  • Mironov, V, Nagy-Mehesz, A, Kasyanov, V, Ozolanta, I, Pereira, FDAS, Rezende, RA, da Silva, JVL: Enabling technologies for organ printing: toward organ biofabrication line. Int. J. Artif. Organs Vol. 34, pp. 623 - 623, 2011


  • Mironov, V, Nagy-Mehesz, A, Kasyanov, V, Ozolanta, I, Pereira, FDAS, Rezende, RA, da Silva, JVL: Enabling technologies for organ printing: toward organ biofabrication line. Int. J. Artif. OrgansVol. 34, pp. 623 - 623, 2010

  • Visconti, RP, Kasyanov, V, Gentile, C, Zhang, J, Markwald, RR, Mironov, V.: Towards organ printing: engineering an intra-organ branched vascular tree. ExpertOpin. Biol. Ther. Vol. 10, pp. 409 - 420, 2010

  • Chua C.K., Liu D., Leong K.F., Mironov V., Kasyanov V.: A minibioreactor for developing "perfused" capillaries in cardiomyocyte aggregates. Innovative Developments in Design and Manufacturing - Advanced Research in Virtual and Rapid Prototyping Vol., pp. 27 - 30, 2010


  • Kasyanov, VA, Hodde, J, Hiles, MC, Eisenberg, C, Eisenberg, L, DeCastro, LEF, Ozolanta, I, Murovska, M, Draughn, RA, Prestwich, GD, Markwald, RR, Mironov, V: Rapid biofabrication of tubular tissue constructs by centrifugal casting in a decellularized natural scaffold with laser-machined micropores. J. Mater. Sci.-Mater. Med. Vol. 20, pp. 329 - 337, 2009

  • Mironov, V, Trusk, T, Kasyanov, V, Little, S, Swaja, R, Markwald, R: Biofabrication: a 21st century manufacturing paradigm. Biofabrication Vol. 1, pp.- , 2009

  • Mironov, V, Kasyanov, V: Emergence of clinical vascular tissue engineering. Lancet Vol. 373, pp. 1402 - 1404, 2009

  • Mironov, V, Visconti, RP, Kasyanov, V, Forgacs, G, Drake, CJ, Markwald, RR: Organ printing: Tissue spheroids as building blocks. Biomaterials Vol. 30, pp. 2164 - 2174, 2009

  • Mironov V., Kasyanov V., Nagy-Mehesz A., Moreno R., Hajdu Z., Trusk T., Ozolanta I., Murovska M., Wu Y., Yao H., Beachley V., Wen X., Bradshaw A., Visconti R., Norris R., Markwald R.: Tissue engineering of heart valve leaflet by self-assembly of tissue spheroids biofabricated from human fat tissue derived stem cells. IFMBE ProceedingsVol. 25, pp. 230 - 232, 2009

  • Kalejs M., Stradins P., Lacis R., Ozolanta I., Pavars J., Kasyanov V.: St Jude Epic heart valve bioprostheses versus native human and porcine aortic valves - Comparison of mechanical properties. Interactive Cardiovascular and Thoracic Surgery Vol. 8, pp. 553 - 556, 2009


  • Ragauska A., Apse P., Kasjanovs V., Berzina-Cimdina L.: Influence of ceramic inlays and composite fillings on fracture resistance of premolars in vitro. Stomatologija / issuedbypublicinstitution "Odontologijos studija" ... [etal.] Vol. 10, pp. 121 - 126, 2008

  • Smits L., Ozolanta I., Ozolins V., Lacis A., Kasyanov V.: Biomechanical properties of two synthetic biomaterials for ventricular septaldefect closure in infancy. IFMBE Proceedings Vol. 20 IFMBE, pp. 76 - 79, 2008

  • Ozolins V., Ozolanta I., Smits L., Lacis A., Kasyanov V.: Biomechanical properties of glutaraldehyde treated human pericadium. IFMBE Proceedings Vol. 20 IFMBE, pp. 143 - 145, 2008

  • Kerch, GM, Bayon, Y, Kasyanov, V, Gravagna, P, Clermont, G: Thermal, mechanical and biological properties of PLA fibers. Tissue Eng. Part A Vol. 14, pp. 919 - 919, 2008

  • Pavars J., Stradins P., Lacis R., Ozolanta I., Kasyanov V.: Investigation of biomechanical properties of different elements of human mitral valve. IFMBE Proceedings Vol. 20 IFMBE, pp. 154 - 155, 2008

  • Mironov, V, Kasyanov, V, Markwald, RR, Prestwich, GD: Bioreactor-free tissue engineering: directed tissue assembly by centrifugal casting. Expert Opin. Biol. Ther. Vol. 8, pp. 143 - 152, 2008


  • Mironov, V, Kasyanov, V, Markwald, R: Bioprintling - Directedtissueself-assembly.Chem. Eng. Prog. Vol. 103, pp. S12 - S17, 2007

  • Liu, YR, Kasyanov, V, Schoephoerster, RT: Effect of fiber orientation on the stress distribution within a leaflet of a polymer composite heart valve in the closed position. J. Biomech. Vol. 40, pp. 1099 - 1106, 2007

  • Morris R.A., Damon B., Mironov V., Kasyanov V., Ramamurthi A., Moreno-Rodriguez R., Trusk T., Potts J.D., Goodwin R.L., Davis J., Hoffman S., Wen X., Sugi Y., Kern C.B., Mjaatvedt C.H., Turner D.K., Oka T., Conway S.J., Molkentin J.D., Forgacs G., Markwal: Periost in regulates collagen fibrillogenesis and the biomechanical properties of connective tissues. Journal of Cellular Biochemistry Vol. 101, pp. 695 - 711, 2007


  • Gallocher, SL, Aguirre, AF, Kasyanov, V, Pinchuk, L, Schoephoerster, RT: A novel polymer for potentialusein a trileaflet heart valve. J. Biomed. Mater. Res. Part B Vol. 79B, pp. 325 - 334, 2006

  • Mironov V., Kasyanov V.A., Yost M.J., Visconti R., Twal W., Trusk T., Wen X., Ozolanta I., Kadishs A., Prestwich G.D., Terracio L., Markwald R.R.: Cardiovascular tissue engineering I. Perfusion bioreactors: A review. Journal of Long-Term Effects of Medical Implants Vol. 16, pp. 111 - 130, 2006

  • Kasyanov, V, Isenburg, J, Draughn, RA, Hazard, S, Hodde, J, Ozolanta, I, Murovska, M, Halkes, SB, Vrasidas, I, Liskamp, RMJ, Pieters, RJ, Simionescu, D, Markwald, RR, Mironov, V: Tannic acid mimicking dendrimers as small intestine submucosa stabilizing nanomordants. Biomaterials Vol. 27, pp. 745 - 751, 2006

Doctoral Thesis


Elīna Ligere: Clinical, echocardiographic and biomechanical aspects of coarctation of the aorta in infants in Latvia. Supervisors: Prof. Aris Lācis, Prof. Vladimirs Kasjanovs.

Normunds Sikora: Myocardial Protection and Cardiopulmonary Bypass in Paediatric Cardiac Surgery. Biomechanical and Structural Properties of Neonatal Coronary Arteries. Supervisors: Prof. Āris Lācis, Prof. Vladimirs Kasjanovs.


Valts Ozoliņš: Echocardiographic, biomechanical, structural assessment of the function of plastic material (autopericardium) used in surgeries of atrium and atrial partitioning, pulmonary trunk and aorta in different variants of hereditary cardiac diseases”. Supervisors: Prof. Iveta Ozolanta, Prof. Vladimirs Kasjanovs.


Arnolds Kadišs: Complex Study of New Small Diameter Composite Vascular Graft and Evaluation of its Practical Use. Supervisors: Prof.Iveta Ozolanta, Prof. Vladimirs Kasjanovs.


Pēteris Stradiņš: Use of human heart pulmonary valve for reconstruction of aortic valve.Studies of biomechanical properties and structure. Supervisors: Prof. Iveta Ozolanta, Prof. Vladimirs Kasjanovs.

Intellectual property

  • United States Patent, No. 8,124,001, B1. Synthetic vascular tissue and method of forming same. Wen Xuejun, Beachley Vince Z., Mironov Vladimir A., Kasyanov Vladimir A. February 28, 2012

  • Latvian Patent, Nr. P-12-78, Int. Cl. C12N5/074, C12N5/077, BB2Y5/00. Method to create spatially ordered cell structures from adult living cells. Vladimirs Kozlovs, Andrejs Karpovs, Viktoija Priedīte, Dace Avotiņa, Pēteris Stradiņš, Martiņš Kalējs, Vladimirs Kasjanovs, Vladimirs Mironovs. 20.10.2012.