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16 Dzirciema Str., Rīga, LV-1007

Phone: +371 67061542

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  • ERAF project No. 2014/0048/2DP/ Development of new method for detection of genetic variations significant in reproduction. Project manager: I. Kempa. Duration: 2014-2015

Grants by the Latvian Council of Science

  • Latvian Council of Sciences grant No. 09.1384. Expression of genetically determined modulations of liver metabolism in cases of different hepatic pathologies. Duration: 2009–2012

  • Latvian Council of Sciences grant No. 09.1116. Diagnosis of human pathology caused by mitochondrial DNA mutations and analysis of etiopathogenesis. Duration: 2009–2012

  • Implementation of the sub-project “Polymorphic variants of xenobiotic metabolism genes in the population of Latvia and their relation to pathology” of the Latvian Council of Sciences project No. 10.0010 “Genetic research of diseases etiology, pathogenesis, and human ageing processes of the Latvian population”. Duration: 2010–2013

  • Latvian Council of Sciences grant No. 09.1115. “Importance of risk factors in the development of non-syndromic cleft palate, cleft lip with/without cleft palate for the population in Latvia”. Duration: 2009–2011

  • Private-public partnership “Multi-disciplinary Research Consortium on Major Pathologies Threatening the Life Expectancy and Quality of Life of the Latvian Population”. Sub-project No. 13 “Prompt and effective diagnostics of chronic respiratory diseases, introduction of new therapy methods into the clinical practice”. Duration: 2006–2010

  • Latvian Council of Sciences cooperation project No. 05.0023. “Research of genofund of Latvia in relation to human pathology”. Duration: 2005–2009

Projects financed by other international institutions

  • Latvia-Lithuania-Taiwan project “In craniofacial morphogenesis involved and orofacial clefts identification genes predisposing in human genome”. Duration: 2003–2006



  • Pliss L, Timša L, Rootsi S, Tambets K, Pelnena I, Zole E, Puzuka A, Sabule A, Rozane S, Lace B, Kucinskas V, Krumina A, Ranka R, Baumanis V. Y-Chromosomal Lineages of Latvians in the Context of the Genetic Variation of the Eastern-Baltic Region. Ann Hum Genet. 2015 Nov;79(6):418-30. doi: 10.1111/ahg.12130. Epub 2015 Sep 28.



  • Piekuse, L., Kreile, M., Zarina, A., Shteinberga, Z., Sondore, V., Keiss, J., Lace, B., Krumina, A. Association between inherited monogenic liver disorders and chronic hepatitis C. World Journal of Hepatology (In press).

  • Piekuse, L., Lace, B., Kreile, M., Sadovska, L., Kempa, I., Daneberga, Z., Micule, I., Sondore, V., Keiss, J., Krumina, A. Impact of the genes UGT1A1, GSTT1, GSTM1, GSTA1, GSTP1 and NAT2 on acute alcohol-toxic hepatitis. Central European Journal of biology, Vol 9 (2), February 2014, pp 125-130. doi: 10.2478/s11535-013-0249-y

  • Kevere, L., Purvina, S., Bauze, D., Zeibarts, M., Andrezina, R., Piekuse, L., Brekis, E., Purvins, I. Homocysteine and MTHFR C677T polymorphism in children and adolescents with psychotic and mood disorders. Nord J Psychiatry. 2014 Feb;68(2):129-36. doi: 10.3109/08039488.2013.782066. Epub 2013 Apr 16. PMID: 23586533\

  • Bauze, D., Piekuse, L., Kevere, L., Kronberga, Z., Rizevs, A., Vaivade, I., Viksne, K., Andrezina, R., Lace, B. Association a Single Nucleotide Polymorphism in Chromosome 11 with Autism Spectrum Disorder in a North-Eastern European Population. Proceedings of the Latvian Academy of Science, 2013 (In press).

  • Berza, N., Zodzika, J., Kroica, J., Reinis, A., Skadins, I., Piekuse, L., Melngaile, O., Pundure,R., Lukojanova, I., Vasina, O. Association between Lactobacillus species and bacterial vaginosis-related bacteria, and bacterial vaginosis scores in small population of pregnant Latvian women. International Journal of Collaborative Research on Internal Medicine & Public Health, 2013, Vol. 5 No. 5, pp255-264.

  • Skesters, A. P., Silova, A. A., Spadiene, A. G., Savickiene, N. Z., Rusakova, N. J., Larmane, L. T.,  Moisejevs, G. O. Redox status blood of patients with new-found type-2 diabetes mellitus before and after duration of administration of natural antioxidants. Prenosology and Healthy Lifestyle, 1(12), 2013, 76-79 pp.; (in Russian)


  • Kevere L., Purvina S., Bauze D., Zeibarts M., Andrezina R., Rizevs A., Jelisejevs S., Piekuse L., Kreile M., Purvins I.: Elevated serum levels of homocysteinedisord as an early prognostic factor of psychiatric disorders in children and adolescents, Schizophr Res Treatment. 2012(2012:373261), pp., 2012, doi:10.1155/2012/373261. Epub, 2012, Oct 2.

  • Sadovska L., Piekuse L., Kreile M., Keiss J., Krumina A.: CCR5-32 and UGT1A1 28-mutations in HCV patients, Immunology. Vol. 137 Suppl. 1, pp. 497-497, 2012

  • Letra A., Fakhouri W., Fonseca R., Menezes R., Kempa I., Prasad J., McHenry T., Lidral A., Moreno L., Murray J., Daack-Hirsch S., Marazita M., Castilla E., Lace B., Orioli I., Granjeiro J., Schutte B., Vieira A.: Interaction between IRF6 and TGFA Genes Contribute to the Risk of Non syndromic Cleft Lip/Palate, PLoS One. 7(9), 2012, doi:10.1371/journal.pone.0045441

  • Lace B., Kempa I., Klovins J., Stavusis J., Krumina A., Akota I., Barkane B., Vieira A., Nagle E., Grinfelde I., Maulina I.: BCL3 gene role in facial morphology, Birth Defects Res. Part A-Clin. Mol. Teratol. Vol. 94(11), pp. 918-924, 2012

  • Kreile M., Daneberga Z., Ziemele I., Eglite I., Grinfelde I., Sviridova D., Krumina Z.: Shwachman diamond syndrome mimics disorder of galactose metabolisms, J. Inherit. Metab. Dis.. Vol. 35 Suppl. 1, pp. S166-S166, 2012


  • Makrecka, M., Kuka, J., Liepinsh, E., Dambrova, M.: T Nikopensius, T., Kempa, I., Ambrozaityte, L., Jagomagi, T., Saag, M., Matuleviciene, A., Utkus, A., Krjutskov, K., Tammekivi, V., Piekuse, L., Akota, I., Barkane, B., Krumina, A., Klovins, J., Lace, B., Kucinskas, V., Metspalu, A.: Variation in FGF1, FOXE1, and TIMP2 genes is associated with nonsyndromic cleft lip with or without cleft palate. Birth Defects Res. Part A-Clin. Mol. Teratol. Vol. 91, pp. 218–225, 2011
  • Lace, B., Kempa, I., Piekuse, L., Grinfelde, I., Klovins, J., Pliss, L., Krumina, A., Vieira, A.R.: Association studies of candidate genes and cleft lip and palate taking into consideration geographical origin. European Journal of Oral Sciences, Vol. 119, pp. 413–417, 2011 

  • Puzuka, A., Pronina, N, Grinfelde, I, Erenpreiss, J, Lejing, V, Bars, J, Pliss, L, Pelnena, I, Baumanis, V, Krumina, A.: Y chromosome-a tool in infertility studies of Latvian population. Russ. J. Genet. Vol. 47, pp. 347–353, 2011


  • Nikopensius, T, Jagomagi, T, Krjutskov, K, Tammekivi, V, Saag, M, Prane, I, Piekuse, L, Akota, I, Barkane, B, Krumina, A, Ambrozaityte, L, Matuleviciene, A, Kucinskiene, ZA, Lace, B, Kucinskas, V, Metspalu, A.: Genetic Variants in COL2A1, COL11A2, and IRF6 Contribute Risk to Nonsyndromic Cleft Palate. Birth Defects Res. Part A-Clin. Mol. Teratol. Vol. 88, pp. 748–756, 2010


  • Krumina, A, Keiss, J, Sondore, V, Chernushenko, A, Cernevska, G, Zarina, A, Micule, I, Piekuse, L, Kreile, M, Lace, B, Krumina, Z, Rozentale, B: From Clinical and Biochemical to Molecular Genetic Diagnosis of Wilson Disease in Latvia. Russ. J. Genet. Vol. 44, pp. 1195 - 1200, 2008
  • Puzuka, A, Krumina, A, Prane, I, Grinfelde, I, Pronina, N, Lejins, V, Erenpreiss, J, Baumanis, V: Incidence of Y chromosomal microdeletions and CFTR gene mutations in infertile males in Latvia. FEBS J. Vol. 275, pp. 100 - 100, 2008

  • Pliss, L, Pelnena, I, Puzuka, A, Baumanis, V, Krumina, A: Genetic analysis of 12 Y-chromosomal STRs haplotypes in the Latvian population. FEBS J. Vol. 275, pp. 424 - 424, 2008


  • Pliss, L, Baumanis, V, Krumina, A, Puzuka, A, Tambets, K, Villems, R: Phylogenetic analysis of the predominant mtDNA variant, haplogroup H. FEBS J. Vol. 274, pp. 285–285, 2007

Doctoral Thesis






  • Baiba Lāce: Analysis of molecular genetics and clinical aspects of A1AT deficiency in Latvia. Scientific supervisor: Prof. Astrīda Krūmiņa


Rīga Stradiņš University, 16 Dzirciema Street, Rīga, LV-1007, Latvia, +371 67409261 (UTC +2),