Modern approaches to infection agents, their role in infections relevant for Latvia

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Unique research excellence on immunomodulating viruses has been developed on the basis of A. Kirchenstein Microbiology and Virology Institute (MVI).

Close collaboration with Department of Infectology and Department of Neurology (tick-borne encephalitis). New research on Chronic Fatigue Syndrome, participation in the European Observatory (EUROMENE). Prospective research on immunomodulating therapies used for treatment of malaria, TBC and HIV.



  • Chapenko S., Trociukas I., Donina S., Chistyakov M., Sultanova A., Gravelsina S., Lejniece S., Murovska M.: Relationship between beta-herpes viruses reactivation and development of complications after autologous peripheral blood stem cell transplantation, J. Med. Virol. 84(12), pp. 1953-1960, 2012, doi:10.1002/jmv.23412/

  • Roga S., Strumfa I., Kuleznova S., Chapenko S., Rasa S., Murovska M.: Morphology of non-specified encephalopathy in cases of polymerase chain reaction proved presence of human herpesvirus-6, Virchows Arch. Vol. 461 Suppl. 1, pp. S91-S91, 2012

  • Sadovska L., Piekuse L., Kreile M., Keiss J., Krumina A.: CCR5-32 and UGT1A1 28-mutations in HCV patients, Immunology. Vol. 137 Suppl. 1, pp. 497-497, 2012

  • Kurjane N., Eglite J., Tolpak N., Debeljak M., Avcin T.: The first case of familial Mediterranean fever diagnosed in Latvia. J. Clin. Immunol. Vol. 32 Suppl. 1, pp. 117-117, 2012

  • Prokofjeva T., Skangale A., Eglite I., Grantina I., Marodi L., Gardovska D.: Severe combined immunodeficiency (SCID) in Latvia. J. Clin. Immunol.Vol. 32 Suppl. 1, pp. 335-336, 2012

  • Viksna L., Januskevica I., Sondore V., Rozentale B., Eksteina I., Ivanovs A., Kolupajeva T., Riekstina V.: Problems of HIV positive tuberculosis patients' health care in Latvia, Retrovirology. Vol. 9 Suppl. 1, pp. -, 2012, doi:10.1186/1742-4690-9-S1-P69

  • Groma V., Kazanceva A., Nora-Krukle Z., Murovska M.: Oropharyngeal malignant epithelial cell, lymphocyte and macrophage CD44 surface receptors for hyaluronate are expressed in sustained EB Vinfection: Immunohistochemical data and EBV DNA tissue indices, Pathol. Res. Pract.. 208(9), pp. 518-526, 2012, doi:10.1016/j.prp.2012.05.017

  • Capenko S., Kozireva S., Folkmane I., Bernarde K., Rozentals R., Murovska M.: Anemia as a Complication of Parvovirus B19 Infection in Renal Transplant Recipients, Med. Lith.. 48(6), pp. 299-304, 2012

  • Chapenko S., Krumina A., Logina I., Rasa S., Chistjakovs M., Sultanova A., Viksna L., Murovska M.: Association of active human herpesvirus-6, -7 and parvovirus b19 infection with clinical outcomes in patients with myalgic encephalomyelitis/chronic fatigue syndrome, Adv Virol. 2012(2012:205085), pp. -, 2012, doi:10.1155/2012/205085. Epub 2012 Aug 13.

  • Chlibek R., Anca I., Andre F., Cizman M., Ivaskeviciene I., Mangarov A., Meszner Z., Perenovska P., Pokorn M., Prymula R., Richter D., Salman N., Simurka P., Tamm E., Tesovic G., Urbancikova I., Zavadska D., Usonis V.: Adult vaccination in 11 Central European countries - Calendars are not just for children, Vaccine. 30(9), pp. 1529-1540, 2012, doi:10.1016/j.vaccine.2011.12.091


  • Valdovska, A, Pilmane, M.: Histopathologic and immunohistochemical lesions in liver of mink infected with Aleutian disease virus. Pol. J. Vet. Sci. Vol. 14, pp. 69 - 76, 2011

  • Tolmane, I., Rozentale, B., Keiss, J., Arsa, F., Brigis, G., Zvaigzne, A.: The prevalence of viral hepatitis C in Latvia: A population-based study. Medicina (Kaunas) Vol. 47, pp. 532 - 535, 2011

  • Nora-Krukle, Z., Chapenko, S., Logina, I., Millers, A., Platkajis, A., Murovska, M.: Human herpesvirus 6 and 7 reactivation and disease activity in multiple sclerosis. Medicina (Kaunas) Vol. 47, pp. 527 - 531, 2011


  • Karnite, A, Brigis, G, Skrule, J, Lazdina, A, Upmace, I.: Potential years of life lost due to human immunodeficiency virus (HIV) infection in Latvia from 1991 to 2008. Eur. J. Public Health Vol. 20, pp. 204 - 204, 2010

  • Rasa, S, Paludan, SR, Reinert, L.: Role for TLR2 and TLR9 in Chemokine Expression During Herpesvirus Infection in Mice. Scand. J. Immunol. Vol. 71, pp. 536 - 537, 2010

  • Kenina V., Auce P., Priede Z., Irbe I., Vainsteina L., Smeltere E., Millers A.: Cytomegalovirus chronic infection as a risk factor for stroke: A prospective study. Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences Vol. 64, pp. 133 - 136, 2010


  • Chapenko, S, Folkmane, I, Ziedina, I, Chistyakovs, M, Rozentals, R, Krumina, A, Murovska, M: Association of HHV-6 and HHV-7 reactivation with the development of chronic allograft nephropathy. J. Clin. Virol. Vol. 46, pp. 29 - 32, 2009

  • Folkmane, I, Chapenko, S, Ziedina, I, Chistyakovs, M, Rozental, R, Murovska, M: Impact of concurrent HHV-6 AND HHV-7 Infection onf chronic allograft nephropathy development. Transpl. Int. Vol. 22, pp. 21 - 21, 2009


  • Prokofjeva, T, Kovalova, Z, Nikulshin, S, Marodi, L, Gardovska, D: The first registered case of Wiskott-Aldrich syndrome in Latvia. Clin. Exp. Immunol. Vol. 154, pp. 188 - 188, 2008

  • Kozireva, SV, Zestkova, JV, Mikazane, HJ, Kadisa, AL, Kakurina, NA, Lejnieks, AA, Danilane, IN, Murovska, MF: Incidence and clinical significance of parvovirus B19 infection in patients with rheumatoid arthritis. J. Rheumatol. Vol. 35, pp. 1265 - 1270, 2008

  • Lejniece, G, Puga, I, Sultanova, A, Murovska, M, Chapenko, S: HHV-6 and HHV-7 activation in early period after autologous peripheral blood stem cell transplantation. Haematol-Hematol. J. Vol. 93, pp. 141 - 141, 2008

  • Lejniece, G, Auzina, D, Lejnieks, A, Kozireva, S, Chapenko, S, Chistjakov, M, Nora, Z, Murovska, M: Incidence of human herpes virus type 7 (HHV-7) Infections in patients with hematological malignacies whose disease course is accompanied by neutropenia. Haematol-Hematol. J. Vol. 93, pp. 69 - 69, 2008

  • Kolupajeva T., Aldins P., Guseva L., Dusacka D., Sondore V., Viksna L., Rozentale B.: HIV drug resistance tendencies in latvia. Central European Journal of Public Health Vol. 16, pp. 138 - 140, 2008


  • Cozzi-Lepri, A, Phillips, AN, Ruiz, L, Clotet, B, Loveday, C, Kjaer, J, Mens, H, Clumeck, N, Viksna, L, Antunes, F, Machala, L, Lundgren, JD: Evolution of drug resistance in HIV-infected patients remaining on a virologically failing combination antiretroviral therapy regimen. Aids Vol. 21, pp. 721 - 732, 2007

  • Bratslavska, O, Platace, D, Miklasevics, E, Fuchs, D, Martinsons, A: Influence of neopterin and 7,8-dihydroneopterin on the replication of Coxsackie type B5 and influenza A viruses. Med. Microbiol. Immunol. Vol. 196, pp. 23 - 29, 2007


  • Chapenko, S, Krumina, A, Kozireva, S, Nora, Z, Sultanova, A, Viksna, L, Murovska, M: Activation of human herpesviruses 6 and 7 in patients with chronic fatigue syndrome. J. Clin. Virol. Vol. 37, pp. S47 - S51, 2006