Cancer: research on clinical and molecular characteristics and their advancement for prevention, early diagnosis and improvement of treatment strategies

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This research strain investigates oncogenic mutations relevant for Latvian population. Two specific mutations have been scrutinised for breast and ovarian cancer, reflected in cited publications. Another strain of cancer research focuses on oncoviruses, following the tradition which started from groundbreaking discovery of melanoma virotherapy in the 1960s.

Publications

2012

  • Maksimenko J., Reteris M., Irmejs A., Trofimovics G.: Operable breast cancer in very young women, is there a difference? Breast. Vol. 21 Suppl. 1, pp. S11-S11, 2012/

  • Macuks R., Baidekalna I., Donina S.: An ovarian cancer malignancy risk index composed of HE4, CA125, ultrasonographic score, and menopausal status: use in differentiation of ovarian cancers and benign lesions, Tumor Biol.33(5), pp. 1811-1817, 2012, doi:10.1007/s13277-012-0440-1

  • Abolins A., Strumfa I., Simtniece Z., Vanags A., Trofimovics G., Gardovskis J.: Analysis of BCL2 oncoprotein expressing breast cancer by molecular subtype, Virchows Arch.. Vol. 461 Suppl. 1, pp. S234-S234, 2012

  • Abolins A., Strumfa I., Volanska G., Vanags A., Strumfs B., Gardovskis J.: Extramammary tumour metastasis in the breast, Virchows Arch.. Vol. 461 Suppl. 1, pp. S234-S234, 2012

  • Strumfa I., Abolins A., Gekis J., Pavlovs K., Vanags A., Grusina-Ujumaza J., Volanska G., Gardovskis J.: Expression of CD44, E-Cadherin and Bcl-2 in lung cancer, Virchows Arch. Vol. 461 Suppl. 1, pp. S71-S71, 2012

  • Strumfa I., Abolins A., Gekis J., Pavlovs K., Vanags A., Strumfs B., Volanska G., Gardovskis J.: Localized nodular pulmonary and thoracic cage amyloidosis, Virchows Arch.Vol. 461 Suppl. 1, pp. S71-S71, 2012

  • Kreile M., Daneberga Z., Ziemele I., Eglite I., Grinfelde I., Sviridova D., Krumina Z.: Shwachman diamond syndrome mimics disorder of galactose metabolisms, J. Inherit. Metab. Dis.. Vol. 35 Suppl. 1, pp. S166-S166, 2012

  • Auslands K., Liepa Z., Apskalne D., Ozols R.: Initial experience with using frameless image – guided radiosurgery for the treatment of brain metastases, Neuro-Oncology. Vol. 14 Suppl. 3, pp. 76-77, 2012

  • Aitullina A., Baumane K., Pliss L., Zalite S., Sepetiene S., Laganovska G., Baumanis V.: Molecular mitochondrial (MT) pathology in eye diseases, FEBS J.. Vol. 279 Suppl. 1, pp. 310-311, 2012

  • Krisjane Z., Urtane I., Krumina G., Neimane L., Ragovska I.: The prevalence of TMJ osteoarthritis in asymptomatic patients with dentofacial deformities: a cone-beam CT study, Int. J. Oral Maxillofac. Surg. 41(6), pp. 690-695, 2012, doi:10.1016/j.ijom.2012.03.006

  • Stukena I., Kalvelis A., Bahs G., Skuja I., Lejnieks A.: Metabolic syndrome associated with higher CVD risk for women, Circulation. 125(19), pp. E906-E906, 2012

  • Melbarde-Gorkusa I., Irmejs A., Berzina D., Strumfa I., Abolins A., Gardovskis A., Subatniece S., Trofimovics G., Gardovskis J., Miklasevics E.: Challenges in the management of a patient with Cowden syndrome: case report and literature review, Hered. Cancer Clin. Pract. Vol. 10, 2012, doi:10.1186/1897-4287-10-5

  • Bokums K., Irmejs A., Gardovskis J.: Intercostobrachial Nerve Role in the Postmastectomy Pain Syndrome, Eur. J. Cancer. Vol. 48 Suppl. 1, pp. S195-S195, 2012

  • Macuks R., Baidekalna I., Donina S.: Urinary Concentrations of Human Epididymis Secretory Protein 4 (He4) in The Diagnosis of Ovarian Cancer: A Case-Control Study, Asian Pac. J. Cancer Prev. 13(9), pp. 4695-4698, 2012, doi:10.7314/APJCP.2012.13.9.4695

  • Vainauska D., Kozireva S., Karpovs A., Cistjakovs M., Barisevs M.: A Novel Approach for Nucleic Acid Delivery Into Cancer Cells, Med. Lith. 48(6), pp. 324-329, 2012

  • Vanags, A., Štrumfa, I., Gardovskis, A., Abolins, A., Simtniece, Z., Trofimovičs, G., Gardovskis, J.: The first evidence of hereditary and familial gastric cancer in Latvia: Implications for prevention, Medicine (Lithuania). 48(6), pp. 317-323, 2012

  • Berziņa, D., Irmejs, A., Kalniete, D., Borošenko, V., Nakazawa-Miklaševiča, M., Ribenieks, K., Trofimovičs, G., Gardovskis, J., Miklaševičs, E.: Novel germline MLH1 and MSH2 mutations in Latvian lynch syndrome families, Experimental Oncology, 34 (1), pp. 49-52.. 34(1), pp. 49-52, 2012

  • Stankevica J., Macuks R., Baidekalna I., Donina S.: Midline involvement as a risk factor for vulvar cancer recurrence, Asian Pac J Cancer Prev. 13(10), pp. 5237-5240, 2012

2011

  • Volanska, G., Strumfa, I., Zalite, IO, Gardovskis, J., Miklasevics, E., Vanags, A.: Localized amyloidosis of sternum as the manifestation of multiple myeloma. Virchows Arch. Vol. 459, pp. S104 - S104, 2011

  • Volanska, G., Abolins, A., Strumfa, I., Nikulsins, S., Abolina, M., Gardovskis, J., Miklasevics, E.: Primary diffuse large B-cell lymphoma of the breast. Virchows Arch. Vol. 459, pp. S83 - S83, 2011

  • Lejniece, S., Kluce, G., Balins, A., Tomins, P, Lejnieks, A.: Successful treatment of prostate cancer in a case of severe haemophilia A patient. J. Thromb. Haemost. Vol. 9, pp. 219 - 219, 2011

  • Silins, I., Krams, A., Apsvalks, M., Sirgeda, A., Petersons, A.: Histological subtypes of lung cancer in operated patients. J. Thorac. Oncol. Vol. 6, pp. S1406 - S1407, 2011

  • Ujumaza, JG, Ambalovs, G., Vanags, A., Strumfa, I., Basko, J., Gardovskis, J., Kopeika, U., Pirtnieks, A.: Analysis of lung cancer histology by family oncologic history in a university hospital in Latvia. J. Thorac. Oncol. Vol. 6, pp. S1525 - S1526, 2011

  • Kalniete, D., Nakazawa-Miklasevica, M., Strumfa, I., Irmejs, A., Subatniece, S, Gardovskis, J, Miklasevics, E.: Micro-rna expression in heritable and sporadic breast cancer tissues. Ann. Oncol. Vol. 22, pp. 34 - 34, 2011

  • Berzina, D, Zestkova, J, Strumfa, I, Irmejs, A, Gardovskis, A, Gardovskis, J, Miklasevics, E.: Defection of the BRCA2 mutatuons in Latvian breast/ovarian cancer patients. Ann. Oncol. Vol. 22, pp. 39 - 39, 2011

  • Abolins, A., Vanags, A., Trofimovics, G., Miklasevics, E., Gardovskis, J., Strumfa, I.: Molecular subtype shift in breast cancer upon trastuzumab treatment: A case report. Pol. J. Pathol. Vol. 62, pp. 65 - 68, 2011

  • Plakhins, G., Irmejs, A., Gardovskis, A., Subatniece, S., Rozite, S., Teibe, U., Trofimovics, G., Miklasevics, E., Gardovskis, J.: Evaluation of family histories and analysis of BRCA1 founder mutations in a population-based series of breast and ovarian cancer cases in Latvia. Breast Vol. 20, pp. S30 - S30, 2011

  • Vedmedovska, N, Rezeberga, D, Teibe, U, Melderis, I, Donders, G.: Placental pathology in fetal growth restriction. Eur. J. Obstet. Gynecol. Reprod. Biol. Vol. 155, pp. 36 - 40, 2011

  • Macuks, R, Baidekalna, I, Donina, S.: Comparison of different ovarian cancer detection algorithms. Eur. J. Gynaecol. Oncol. Vol. 32, pp. 408 - 410, 2011

  • Macuks, R, Baidekalna, I, Donina, S.: Diagnostic test for ovarian cancer composed of ovarian cancer symptom index, menopausal status and ovarian cancer antigen CA125. Eur. J. Gynaecol. Oncol. Vol. 32, pp. 286 - 288, 2011

  • Mitra, AV, Bancroft, EK, Barbachano, Y, Page, EC, Foster, CS, Jameson, C, Mitchell, G, Lindeman, GJ, Stapleton, A, Suthers, G, Evans, DG, Cruger, D, Blanco, I, Mercer, C, Kirk, J, Maehle, L, Hodgson, S, Walker, L, Izatt, L, Douglas, F, Tucker, K.: Targeted prostate cancer screening in men with mutations in BRCA1 and BRCA2 detects aggressive prostate cancer: preliminary analysis of the results of the IMPACT study. BJU Int. Vol. 107, pp. 28 - 39, 2011

  • Gultekin M., Dursun P., Vranes B., Laky R., Bossart M., Grabowski JP., Piek JM., Manchanda R., Grimm C., Dallaku K., Babloyan S., Moisei A., Van Gorp T., Cadron I., Markov P., Micevska A., Halaska M., Steffensen KD., Gristsenko L., Nissi R., Lambaudie E.: Gynecologic Oncology Training Systems in Europe: A Report From the European Network of Young Gynaecological Oncologists. Int J Gynecol Cancer Vol. 21, pp. 1500 - 1506, 2011

  • Rivkina A., Vitols G., Murovska M., Lejniece S..: Identifying the stage of new CLL patients using TK, ZAP-70, CD38 levels. Exp Oncol. Vol. 33, pp. 99 - 103, 2011

  • Plakhins, G., Irmejs, A., Gardovskis, A., Subatniece, S., Rozite, S., Bitina, M., Keire, G., Purkalne, G., Teibe, U., Trofimovics, G., Miklasevics, E., Gardovskis, J..: Genotype-phenotype correlations among BRCA1 4153delA and 5382insC mutation carriers from Latvia. BMC Medical Genetics, 12, art. no. 147, . Vol. 12, 2011

  • Mačuks, R., Baidekalna, I., Nuķe, I., Doniņa, S.: Role of a combined soluble interleukine-2 receptor alpha and CA-125 serum marker assay for detection of ovarian cancer. Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences Vol. 65, pp. 7 - 12, 2011

  • Abele, A., Vjaters, E., Irmejs, A., Trofimovičs, G., Miklaševičs, E., Gardovskis, J.: Epidemiologic, clinical, and molecular characteristics of hereditary prostate cancer in Latvia. Medicina (Kaunas) Vol. 47, pp. 579 - 585, 2011

  • Lejniece, S., Murovska, M., Chapenko, S., Breikša, B., Jaunmuktane, Z., Feldmane, L., Ziedina, I., Gomez-Roman, J., Garcia-Cabeza, M., Lejnieks, A.: Progressive multifocal leukoencephalopathy following fludarabine treatment in a chronic lymphocytic leukemia patient. Experimental Oncology Vol. 33, pp. 239 - 241, 2011

2010

  • Vanags, A., Strumfa, I, Gardovskis, A, Borosenko, V, Abolins, A, Teibe, U, Trofimovics, G, Miklasevics, E, Gardovskis, J.: Population screening for hereditary and familial cancer syndromes in Valka district of Latvia. Hered. Cancer Clin. Pract. Vol. 8, 2010

  • Meija, L, Sitova, A., Zeltite, R, Erdmane, D, Rafaels, R, Teibe, U, Lietuvietis, V, Lejnieks, A.: Vitamin D intake and deficiency in men ar risk of prostate cancer. Eur. Urol. Suppl. Vol. 9, pp. 536 - 536, 2010

  • Sivins, A., Ancans, G, Pedrazzani, C, Moisejevs, G, Krumins, V, Boka, V, Roviello, F, Leja, M.: Indexes of surgical quality in gastric cancer surgery: experience of Latvia Oncology Center. Helicobacter Vol. 15, pp. 383 - 383, 2010

  • Ozolins, A, Narbuts, Z, Strumfa, I, Volanska, G, Gardovskis, J.: Diagnostic utility of immunohistochemical panel in various thyroid pathologies. Langenbecks Arch. Surg. Vol. 395, pp. 885 - 891, 2010

  • Macuks, R., Baidekalna, I., Nuke, I., Engele, L, Donina, S.: High diagnostic performance of ovarian cancer detection algorithm consisting of soluble interleukin-2 receptor Alpha and CA125 combined marker assay and malignancy risk index.Tumor Biol. Vol. 31, pp. S113 - S114, 2010

  • Rivkina, A, Murovska, M, Vitols, G, Lejniece, S.: Dynamic change of serum thymidine kinase levels in patients with chronic lymphocytic leukaemia. Haematol-Hematol. J. Vol. 95, pp. 519 - 519, 2010

  • Vanags, A, Strumfa, I, Gardovskis, A, Borosenko, V, Abolins, A, Trofimovics, G, Gardovskis, J.: The clinical characteristics of familial lung cancer (FLC) by population screening. J. Thorac. Oncol. Vol. 5, pp. S52 - S52, 2010

  • Kalnina, I, Kurjane, N, Kirilova, E, Klimkane, L, Kirilov, G, Zvagule, T.: Correlation of altered blood albumin characteristics and lymphocyte populations to tumor stage in gastrointestinal cancer patients. Cancer Biomark. Vol. 7, pp. 91 - 99, 2010

2009

  • Abele, A, Plonis, J, Miklasevics, E, Vjaters, E, Irmejs, A, Gardovskis, J, Trofimovics, G: BRCA2 gene mutation characterization in hereditary prostate cancer patients in Latvia. Eur. Urol. Suppl. Vol. 8, pp. 569 - 569, 2009

  • Pjanova, D, Molven, A, Akslen, LA, Engele, L, Streinerte, B, Azarjana, K, Heisele, O: Identification of a CDK4 R24H mutation-positive melanoma family by analysis of early-onset melanoma patients in Latvia. Melanoma Res. Vol. 19, pp. 119 - 122, 2009

  • Melbarde-Gorkusa, I, Irmejs, A, Miklasevics, E, Strumfa, I, Vagule, B, Grinfelde, I, Gardovskis, J, Subatniece, S, Gardovskis, A: Report of Cowden's syndrome in patient with PTEN mutation. Breast Vol. 18, pp. S75 - S75, 2009

  • Borosenko, V, Irmejs, A, Melbarde-Gorkusa, I, Gardovskis, A, Pavars, M, Vanags, A, Trofimovics, G, Miklasevics, E, Gardovskis, J: Initial Results of Colorectal Polyposis Research in Latvia. Anticancer Res. Vol. 29, pp. 711 - 715, 2009

  • Pjanova D., Azarjana K., Cema I., Heisele O.: Genetic alteration in melanoma development. Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences Vol. 63, pp. 73 - 80, 2009

2008

  • Irmejs, A, Miklasevics, E, Strumfa, I, Gardovskis, J: Comment on the article Genetic contribution to all cancers: the first demonstration using the model of breast cancers from Poland stratified by age at diagnosis and tumour patholo. Hered. Cancer Clin. Pract. Vol. 6, pp. 66 - 66, 2008

  • Borosenko, V, Irmejs, A, Vanags, A, Melbarde-Gorkusa, I, Gardovskis, A, Pavars, M, Friedl, W, Gardovskis, J: Report on first three APC gene mutation positive FAP families in Latvia. Ann. Oncol. Vol. 19, pp. I40 - I40, 2008

2007

  • Borosenko, V, Irmejs, A, Gardovskis, A, Vanags, A, Miklasevics, E, Melbarde-Gorkusa, I, Bitina, M, Kurzawski, G, Gorski, B, Gardovskis, J: Update on hereditary colorectal cancer screening in Latvia. EJC Suppl. Vol. 5, pp. 242 - 243, 2007

  • Elsakov, P, Foretova, L, Goetz, P, de Groot, JWB, van der Graaf, WTA, Guler, G, Huebner, K, Haites, NE, Hamann, U, Ho, J, Imyanitov, EN, Irmejs, A, Purkalne, G, Bitina, M, Gardovskis, A, Gardovskis, J, Kirova, YM, Fourquet, A, Pierga, JY, Stoppa-Lyonnet,: Discussion on the use of taxanes for treatment of breast cancers in BRCA1 mutations carriers. Hered. Cancer Clin. Pract. Vol. 5, pp. 119 - 143, 2007

  • Irmejs, A, Borosenko, V, Melbarde-Gorkusa, I, Gardovskis, A, Bitina, M, Kurzawski, G, Suchy, J, Gorski, B, Gardovskis, J: Nationwide study of clinical and molecular features of hereditary non-polyposis colorectal cancer (HNPCC) in Latvia. Anticancer Res. Vol. 27, pp. 653 - 658, 2007

  • Donina, S, Kozireva, S, Murovska, M, Boka, V: Detection of p15 gene promoter methylation in serum in gastric cancer patients. Tumor Biol. Vol. 28, pp. 111 - 111, 2007

2006

  • Irmejs A., Miklasevics E., Boroschenko V., Gardovskis A., Vanags A., Melbarde-Gorkusa I., Bitina M., Suchy J., Gardovskis J.: Pilot study on low penetrance breast and colorectal cancer predisposition markers in Latvia. Hereditary Cancer in Clinical Practice Vol. 4, pp. 48 - 51, 2006