Pharmaceutical Chemistry

Study Course Description

Course Description Statuss:Approved

Course Description Version:8.00

Study Course Accepted:12.09.2022 16:49:58

Study Course Information
Course Code:		FKK_002		LQF level:		Level 7
Credit Points:		11.00		ECTS:		16.50
Branch of Science:		Basic Sciences of Medicine, including Pharmacy		Target Audience:		Pharmacy
Study Course Supervisor
Course Supervisor:		Dace Bandere
Study Course Implementer
Structural Unit:		Department of Pharmaceutical Chemistry
The Head of Structural Unit:
Contacts:		Riga, 16 Dzirciema Street, block A 5th Floor, Room No 502, farmkkrsu[pnkts]lv, +371 67061544
Study Course Planning
Full-Time - Semester No.1
Lectures (count)		8	Lecture Length (academic hours)		2	Total Contact Hours of Lectures		16
Classes (count)		12	Class Length (academic hours)		4	Total Contact Hours of Classes		48
Total Contact Hours								64
Full-Time - Semester No.2
Lectures (count)		4	Lecture Length (academic hours)		2	Total Contact Hours of Lectures		8
Classes (count)		14	Class Length (academic hours)		4	Total Contact Hours of Classes		56
Total Contact Hours								64
Full-Time - Semester No.3
Lectures (count)		0	Lecture Length (academic hours)		0	Total Contact Hours of Lectures		0
Classes (count)		12	Class Length (academic hours)		4	Total Contact Hours of Classes		48
Total Contact Hours								48
Part-Time - Semester No.1
Lectures (count)		16	Lecture Length (academic hours)		4	Total Contact Hours of Lectures		64
Classes (count)		16	Class Length (academic hours)		4	Total Contact Hours of Classes		64
Total Contact Hours								128
Part-Time - Semester No.2
Lectures (count)		4	Lecture Length (academic hours)		4	Total Contact Hours of Lectures		16
Classes (count)		4	Class Length (academic hours)		4	Total Contact Hours of Classes		16
Total Contact Hours								32
Study course description
Preliminary Knowledge:
Basic knowledge in inorganic, organic and analytical chemistry, physical pharmacy.
Objective:
Course is aimed to acquire the theoretical knowledge and practical skills that can be used in drug quality control. • Promote knowledge of the main classes of medicinal products and their chemical properties; • Promote understanding of drug structure, synthesis, quality control and specifics of use; • Master the tactics of naming medicines and methods of testing the goodness of medicines; • Carry out the analysis of drug substances containing different dosage forms on the basis of physical and chemical properties, chemical structure and stability.
Topic Layout (Full-Time)
No.	Topic			Type of Implementation		Number	Venue
1	Methods of European Pharmacopeia. Quality control of water and injection water.			Lectures		1.00	auditorium
2	Inorganic drugs. Chemical structure, methods of analysis, the use of medicine.			Lectures		1.00	auditorium
3	Drug naming. Nomenclature of drugs. IUPAC nomenclature.			Lectures		1.00	auditorium
4	Analysis of functional groups.			Lectures		2.00	auditorium
5	Anaesthesic drugs. Chemical structure, methods of analysis, medical use.			Lectures		1.00	auditorium
6	Non-steroidal anti inflamatory drugs and analgetics. Chemical structure, methods of analysis, medical use.			Lectures		1.00	auditorium
7	Barbiturates and Benzodiazepines. Chemical stucture, methods of analysis, medical use.			Lectures		1.00	auditorium
8	Methods of European Pharmacopeia.			Classes		1.00	laboratory
9	Quality control of purified water.			Classes		1.00	laboratory
10	Quality control of NaF and CaCl2.			Classes		1.00	laboratory
11	Quality control of Boric acid sol.			Classes		1.00	laboratory
12	Colloquium – Methods of European Pharmacopeia. Quality control of water and injection water. Inorganic drugs.			Classes		1.00	laboratory
13	Drug naming.			Classes		1.00	laboratory
14	Quality control of Na citrate sol.			Classes		1.00	laboratory
15	Quality control of Rezorcin.			Classes		1.00	laboratory
16	Controlanalysis of Inorganic drugs. Literature review.			Classes		1.00	laboratory
17	Colloquium – Analysis of functional groups. Drug naming.			Classes		1.00	laboratory
18	Quality control of Procaine sol. and Paracetamol.			Classes		1.00	laboratory
19	Quality control of Anesthesia drugs and NSAIDs			Classes		1.00	laboratory
20	NSAIDs melting point detection.			Classes		1.00	laboratory
21	Colloquium – Anesthesia drugs and NSAIDs.			Classes		1.00	laboratory
22	Antihistamines and Gastrointestinal drugs. Chemical structure, methods of analysis, medical use.			Lectures		0.50	auditorium
23	Synthetic antimicrobial drugs. Chemical structure, methods of analysis, medical use.TB drugs. Antiviral and Antiparasitic drugs. Chemical structure, methods of analysis, medical use.			Lectures		0.50	auditorium
24	Biotechnology and drugs. Monoclonal Antibodies.			Lectures		1.00	auditorium
25	Water and fat-soluble vitamins: chemical structure, physico-chemical properties, methods of analysis, the use of medicine.			Lectures		1.00	auditorium
26	Antibiotics and steroidal hormones: chemical structure, physico-chemical properties, methods of analysis, the use of medicine.			Lectures		1.00	auditorium
27	Control analysis.			Classes		1.00	laboratory
28	Presentation of Thesis.			Classes		1.00	laboratory
29	Colloquium – CNS drugs			Classes		0.50	laboratory
30	Biotechnology and drugs.			Classes		1.00	laboratory
31	Monoclonal antibodies			Classes		1.00	laboratory
32	Quality control of Sulfonamides.			Classes		0.50	laboratory
33	Quality control of Nitrofuranes.			Classes		0.50	laboratory
34	Spectroscopic analysis of Nitrofuran sol.			Classes		1.00	laboratory
35	Quality control of Isoniazide.			Classes		1.00	laboratory
36	Controlanalysis			Classes		1.00	laboratory
37	Colloquium- Synthetic antimicrobial drugs.			Classes		0.50	laboratory
38	Introduction of express analysis. Express analysis of mixture, quantitative calculations (seminar).			Classes		1.00	laboratory
39	Vitamins identification reactions. Unknown vitamin preparation determination.			Classes		1.00	laboratory
40	Colloquium: water-soluble vitamins: synthesis, analysis and the use of medicine. Situation tasks of express analysis.			Classes		1.00	laboratory
41	Chemical nomenclature of heterocyclic compounds and condensed systems.			Classes		1.00	laboratory
42	Vitamins containing powder express analysis. Quantitative express analysis calculations.			Classes		1.00	laboratory
43	Quantitative analysis of antigrippin powder.			Classes		1.00	laboratory
44	Colloquium: fat-soluble vitamins: synthesis, analysis and the use of medicine. Situation tasks of express analysis.			Classes		1.00	laboratory
45	Purine derivatives: characteristics, analysis.			Classes		1.00	laboratory
46	Express analysis of concentrates and injections.			Classes		1.00	laboratory
47	Express analysis of perishable and fragile preparations.			Classes		1.00	laboratory
48	Express analysis of eye drops.			Classes		1.00	laboratory
49	Hormones: chemical structure, physico-chemical properties, methods of analysis, the use of medicine.			Classes		1.00	laboratory
50	Antibiotics: chemical structure, physico-chemical properties, methods of analysis, the use of medicine.			Classes		1.00	laboratory
51	Clinical seminar – Vitamins, hormone preparations and antibiotics, chemical structure and pharmacokinetics, analysis, role in medicine.			Classes		1.00	laboratory
52	Semester exam.			Classes		1.00	laboratory
Topic Layout (Part-Time)
No.	Topic			Type of Implementation		Number	Venue
1	Methods of European Pharmacopeia. Quality control of water and injection water.			Lectures		2.00	auditorium
2	Inorganic drugs. Chemical structure, methods of analysis, the use of medicine.			Lectures		1.00	auditorium
3	Drug naming. Nomenclature of drugs. IUPAC nomenclature.			Lectures		1.00	auditorium
4	Analysis of functional groups.			Lectures		2.00	auditorium
5	Anaesthesic drugs. Chemical structure, methods of analysis, medical use.			Lectures		2.00	auditorium
6	Non-steroidal anti inflamatory drugs and analgetics. Chemical structure, methods of analysis, medical use.			Lectures		2.00	auditorium
7	Barbiturates and Benzodiazepines. Chemical stucture, methods of analysis, medical use.			Lectures		2.00	auditorium
8	Methods of European Pharmacopeia.			Classes		0.40	laboratory
9	Quality control of purified water.			Classes		0.70	laboratory
10	Quality control of NaF and CaCl2.			Classes		0.50	laboratory
11	Quality control of Boric acid sol.			Classes		0.50	laboratory
12	Colloquium – Methods of European Pharmacopeia. Quality control of water and injection water. Inorganic drugs.			Classes		0.20	laboratory
13	Drug naming.			Classes		0.50	laboratory
14	Quality control of Na citrate sol.			Classes		0.50	laboratory
15	Quality control of Rezorcin.			Classes		0.50	laboratory
16	Controlanalysis of Inorganic drugs. Literature review.			Classes		0.50	laboratory
17	Colloquium – Analysis of functional groups. Drug naming.			Classes		0.50	laboratory
18	Quality control of Procaine sol. and Paracetamol.			Classes		0.50	laboratory
19	Quality control of Anesthesia drugs and NSAIDs			Classes		0.50	laboratory
20	NSAIDs melting point detection.			Classes		0.50	laboratory
21	Colloquium – Anesthesia drugs and NSAIDs.			Classes		0.50	laboratory
22	Antihistamines and Gastrointestinal drugs. Chemical structure, methods of analysis, medical use.			Lectures		2.00	auditorium
23	Synthetic antimicrobial drugs. Chemical structure, methods of analysis, medical use.TB drugs. Antiviral and Antiparasitic drugs. Chemical structure, methods of analysis, medical use.			Lectures		2.00	auditorium
25	Water and fat-soluble vitamins: chemical structure, physico-chemical properties, methods of analysis, the use of medicine.			Lectures		2.00	auditorium
26	Antibiotics and steroidal hormones: chemical structure, physico-chemical properties, methods of analysis, the use of medicine.			Lectures		2.00	auditorium
27	Control analysis.			Classes		0.50	laboratory
28	Presentation of Thesis.			Classes		0.50	laboratory
29	Colloquium – CNS drugs			Classes		0.50	laboratory
32	Quality control of Sulfonamides.			Classes		0.50	laboratory
33	Quality control of Nitrofuranes.			Classes		0.50	laboratory
34	Spectroscopic analysis of Nitrofuran sol.			Classes		0.50	laboratory
35	Quality control of Isoniazide.			Classes		0.50	laboratory
36	Controlanalysis			Classes		0.50	laboratory
37	Colloquium- Synthetic antimicrobial drugs.			Classes		0.50	laboratory
38	Introduction of express analysis. Express analysis of mixture, quantitative calculations (seminar).			Classes		0.50	laboratory
39	Vitamins identification reactions. Unknown vitamin preparation determination.			Classes		0.50	laboratory
40	Colloquium: water-soluble vitamins: synthesis, analysis and the use of medicine. Situation tasks of express analysis.			Classes		0.50	laboratory
41	Chemical nomenclature of heterocyclic compounds and condensed systems.			Classes		0.50	laboratory
42	Vitamins containing powder express analysis. Quantitative express analysis calculations.			Classes		0.50	laboratory
43	Quantitative analysis of antigrippin powder.			Classes		0.50	laboratory
44	Colloquium: fat-soluble vitamins: synthesis, analysis and the use of medicine. Situation tasks of express analysis.			Classes		0.20	laboratory
45	Purine derivatives: characteristics, analysis.			Classes		0.50	laboratory
46	Express analysis of concentrates and injections.			Classes		0.50	laboratory
47	Express analysis of perishable and fragile preparations.			Classes		0.50	laboratory
48	Express analysis of eye drops.			Classes		1.00	laboratory
49	Hormones: chemical structure, physico-chemical properties, methods of analysis, the use of medicine.			Classes		0.50	laboratory
50	Antibiotics: chemical structure, physico-chemical properties, methods of analysis, the use of medicine.			Classes		0.50	laboratory
51	Clinical seminar – Vitamins, hormone preparations and antibiotics, chemical structure and pharmacokinetics, analysis, role in medicine.			Classes		1.00	laboratory
52	Semester exam.			Classes		1.00	laboratory
Assessment
Unaided Work:
During the course students are asked to work with pharmaceutical literature sources to find drug quality control methods. Students are also independently preparing for each lab work finding answers for a set of specific questions in connection with the experimental tasks that helps to understand the experimental work during the labs. A research work – literature review.
Assessment Criteria:
Practical works – Quality control of drugs substances, practical research, colloquiums. Literature review. Colloquia – 80%, research work (literature review) – 20%. Exam – 50% of the mark.
Final Examination (Full-Time):		Exam (Written)
Final Examination (Part-Time):		Exam (Written)
Learning Outcomes
Knowledge:		On successful course completion: • Students should know structures and names of drug substances, methods of drug quality analysis, • be able to identify a compound by reactions of key functional groups, • be able to test the quality of different drug substances, • be able to identify the structural elements of vitamins, hormones and antibiotic drug substances and name a specific drug-containing preparation; • be able to explain the physico-chemical properties of vitamins, hormones and antibiotic drug substances, • be able to compare and select methods for drug substance synthesis, qualitative and quantitative analysis depending on the particular drug substance preparation.
Skills:		On successful course completion students will be able to: • choose and apply chemical and instrumental methods of analysis of drugs, • systematize scientific information of the different groups of medications, their characteristics, properties and use in medicine.
Competencies:		On successful course completion students will be able to evaluate and present the information of drug quality control; Students will be able to independently test the quality of the drug substance based on its physical and chemical properties.
Bibliography
No.	Reference
Required Reading
1	European Pharmacopoeia. – 10th edition. - Strasbourg: Council of Europe, 2021.
2	RSU abonētās zinātniskās datubāzes./RSU subscribed scientific databases.
Additional Reading
1	Patrick, Graham L. An introduction ti medicinal chemistry/ 2017
2	Steen Hansen, Stig Pedersen-Bjergaard, Knut Rasmussen. Introduction to Pharmaceutical Chemical Analysis. Wiley-Blackwell. 2011
3	H.P.Rang (ed) Drug Discovery and Development, Elsevier, 2006 T.Nogrady, D.F.Weaver. MedicinalChemistry. Oxford University Press, 2005.
4	Беликов В. Г. Фармацевтическая химия. В 2 ч. Ч. 1: Общая фармацевтическая химия. Ч. 2: Специальная фармацевтическая химия: Учебник для мед. вузов. — М.: Медпресс-информ, 2007. 624 с.
5	Глущенко Н. Н., Плетенева Т. В., Попков В. А. Фармацевтическая химия — М.: Academia, 2004. 384 с.
6	Shargel L, Wu-Pong S and Yu A. Applied biopharmaceutics and pharmacokinetics: Bioavailability and bioequivalence, 5th ed. McGraw Hill: New York, USA, 2005.
7	Block I.H., Beale I.M. Wilson and Gisvold Textbook of Organic Medicinal and Pharmaceutical Chemistry; Delgado JN, Remers WA, (Eds.); 11th ed., 2004.
8	Applications of Pharmacokinetic Principles in Drug Development. Editor Krishna R.-Kluwer. Academic / Plenum Publishers, 2004.-556 p.
9	R.B. Silverman. The Organic Chemistry of Drug Design and Drug Action. Elsevier, 2004.
10	A.Hillisch, R.Hilgenfeld (eds) Modern Methods of Drug Discovery. Basel – Boston – Berlin, 2003
11	C.G.Wermut (ed) The Practice of Medicinal Chemistry, Amsterdam, 2003
12	D.Cairns, Essentials of Pharmacuetical Chemistry; Pharmaceutical Press, London 2000.
13	Katzung B.G., Masters S.B., Trevor A.J. Basic & Clinical Pharmacology. 12th ed. USA, 2012, pp.659-769.
14	Ābola D., Štokmane A., Vīgestāne R. Zāļu analīze aptiekā. Rīga: Zvaigzne, 1991.
15	Ārvalstu studentiem/For international students
16	Patrick, Graham L. An introduction ti medicinal chemistry/ 2017
17	Steen Hansen, Stig Pedersen-Bjergaard, Knut Rasmussen. Introduction to Pharmaceutical Chemical Analysis. Wiley-Blackwell. 2011
18	H.P.Rang (ed) Drug Discovery and Development, Elsevier, 2006 T.Nogrady, D.F.Weaver. MedicinalChemistry. Oxford University Press, 2005.
19	R.B. Silverman. The Organic Chemistry of Drug Design and Drug Action. Elsevier, 2004.
20	A.Hillisch, R.Hilgenfeld (eds) Modern Methods of Drug Discovery. Basel – Boston – Berlin, 2003
Other Information Sources
1	http://www.iupac.org/