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Medical Chemistry

Study Course Description

Course Description Statuss:Approved
Course Description Version:7.00
Study Course Accepted:26.01.2021
Study Course Information
Course Code:FKK_006LQF level:Level 7
Credit Points:2.00ECTS:3.00
Branch of Science:Pharmacy; Pharmaceutical PharmacologyTarget Audience:Pharmacy
Study Course Supervisor
Course Supervisor:Reinis Vilšķērsts
Study Course Implementer
Structural Unit:Department of Pharmaceutical Chemistry
The Head of Structural Unit:Inga Urtāne
Contacts:Riga, 16 Dzirciema Street, Block A, 5th floor, Room No 502, farmkkatrsu[pnkts]lv, +371 67061544
Study Course Planning
Full-Time - Semester No.1
Lectures (count)4Lecture Length (academic hours)2Total Contact Hours of Lectures8
Classes (count)8Class Length (academic hours)3Total Contact Hours of Classes24
Total Contact Hours32
Part-Time - Semester No.1
Lectures (count)4Lecture Length (academic hours)4Total Contact Hours of Lectures16
Classes (count)4Class Length (academic hours)4Total Contact Hours of Classes16
Total Contact Hours32
Study course description
Preliminary Knowledge:
Knowledge of organic chemistry, physiology, biochemistry.
Objective:
To introduce students to medicinal chemistry and to enable students to the opportunity to learn about medicinal substance existing and change in the body from the administration until elimination.
Topic Layout (Full-Time)
No.TopicType of ImplementationNumberVenue
1Introduction, receptors and methods in medicinal chemistryLectures1.00auditorium
2Enzyme inhibitors. Introduction in PharmacokineticsLectures1.00auditorium
3G protein-coupled receptorsClasses1.00auditorium
4Drug metabolismLectures1.00auditorium
5Ion channelsClasses1.00auditorium
6Cardiovascular drugsLectures1.00auditorium
7ProdrugsClasses1.00auditorium
8Biotransformation reactions of drug substancesClasses1.00auditorium
9Drug dose calculations by using the pharmacokinetic parametersClasses1.00auditorium
10Multitarget drugs. Drug metabolism. Team work/seminarClasses1.00auditorium
11Analysis of scientific publication of medicinal chemistryClasses1.00auditorium
12TestClasses1.00auditorium
Topic Layout (Part-Time)
No.TopicType of ImplementationNumberVenue
1Introduction, receptors and methods in medicinal chemistryLectures1.00auditorium
2Enzyme inhibitors. Introduction in PharmacokineticsLectures1.00auditorium
3G protein-coupled receptorsClasses0.50auditorium
4Drug metabolismLectures1.00auditorium
5Ion channelsClasses0.50auditorium
6Cardiovascular drugsLectures1.00auditorium
7ProdrugsClasses0.50auditorium
8Biotransformation reactions of drug substancesClasses0.50auditorium
9Drug dose calculations by using the pharmacokinetic parametersClasses0.50auditorium
10Multitarget drugs. Drug metabolism. Team work/seminarClasses0.50auditorium
11Analysis of scientific publication of medicinal chemistryClasses0.50auditorium
12TestClasses0.50auditorium
Assessment
Unaided Work:
Individual and group situation tasks during seminars and colloquia; preparation of presentation, analysis of scientific publications in medicinal chemistry.
Assessment Criteria:
Analysis of the article in medicinal chemistry, ability to create new hypothetical compounds with desirable pharmacological activity, presentation of results.
Final Examination (Full-Time):Exam (Written)
Final Examination (Part-Time):Exam (Written)
Learning Outcomes
Knowledge:Student will be able to: • Describe and explain process of mutual interactions of drug substances with various types of receptors; • Describe metabolic changes of drugs; • Explain drug interactions; • Explain prodrugs; • Identify and characterize frequently used groups of cardiovascular drugs.
Skills:Student will be able to: • Identify mechanisms of pharmacological action of the most important groups of medications (enzyme inhibitors, inducers, calcium channel blockers and other); • Objectively evaluate the possible origin of the substance interaction in case of co-administration; • Analyse the articles in medicinal chemistry.
Competencies:Students will be able to assess the physico-chemical principles of drug substances, the possibility of interaction, origin of interaction and structure – activity interaction.
Bibliography
No.Reference
Required Reading
1Patrick, Graham L. An introduction to medicinal chemistry / Graham L. Patrick. Sixth edition. New Yourk, NY : Oxford University Press, 2017. 1703 xxxi, 877 lpp. : ilustrācijas ; 26 cm. ISBN 9780198749691 (pbk.).
2Strohfeldt-Venables, Katja Essentials of inorganic chemistry : for students of pharmacy, pharmaceutical sciences and medicinal chemistry / Katja A. Strohfeldt, School of Pharmacy, University of Reading, UK. Chichester, West Sussex : Wiley, 2015. xiv,
3Ahluwalia, V. K. Medicinal chemistry / V. K. Ahluwalia, Madhu Chopra. New Delhi : Ane Books India, 2008. xxii, 340 lpp. : diagr., il., tab. ISBN 8180521494.
4The practice of medicinal chemistry / edited by Camille Georges Wermuth. 3rd ed. Amsterdam [etc.] : Elsevier/Academic Press, 2008. xxxix, 942 lpp. : il. ISBN 9780123741943.
Additional Reading
1Essentials of pharmaceutical chemistry / edited by Donald Cairns. 4th ed. London ;Chicago : Pharmaceutical Press, c2012. viii, 308 lpp. : il. ISBN 9780853699798.
2Medicinal Chemistry Self Assessment By: Zavod, Robin M.; Harrold, Marc W. Bethesda, MD : ASHP. 2015. eBook; ProQuest Ebook Central datubāzē
3New Developments in Medicinal Chemistry By: Gil, Irene C.; Ortega, Marta P. New York : Nova Science Publishers, Inc. 2009. eBook., ProQuest Ebook Central datubāzē
Other Information Sources
1Zinātniskās literatūras datubāzes: Pubmed (http://www.ncbi.nlm.nih.gov/pubmed); ScienceDirect (http://www.sciencedirect.com/) etc.