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Clinical Pharmacology, Pharmacotherapy, Toxicology

Study Course Description

Course Description Statuss:Approved
Course Description Version:8.00
Study Course Accepted:11.03.2021 10:02:07
Study Course Information
Course Code:FLK_046LQF level:Level 7
Credit Points:2.00ECTS:3.00
Branch of Science:Clinical MedicineTarget Audience:Pharmacy; Clinical Pharmacy
Study Course Supervisor
Course Supervisor:Mārcis Zeibārts
Study Course Implementer
Structural Unit:Department of Pharmacology
The Head of Structural Unit:
Contacts:Riga, Konsula street 21, 1st floor; Marcis[pnkts]Zeibartsatrsu[pnkts]lv; Indra[pnkts]Dumbergaatrsu[pnkts]lv; +371 67613517
Study Course Planning
Full-Time - Semester No.1
Lectures (count)5Lecture Length (academic hours)2Total Contact Hours of Lectures10
Classes (count)7Class Length (academic hours)3Total Contact Hours of Classes21
Total Contact Hours31
Study course description
Preliminary Knowledge:
Anatomy, physiology, pathology, biochemistry, basics of pharmacology, clinical medicine.
Objective:
To provide knowledge of specific pharmacotherapy in accordance with the pathology of the organ systems studied during the study course. To gain knowledge of the effect of therapeutic drugs on disease mechanisms and pathogenesis. The aim is to achieve that students are able to apply their knowledge of the mechanisms of action of drug substances and to integrate pharmacotherapeutic strategies in the treatment of a given case, to anticipate the course of events resulting from the treatment. Students should understand the mechanisms, indications and contraindications, adverse side effects, interactions, toxicity, and focus on the pharmacokinetic properties of each product.
Topic Layout (Full-Time)
No.TopicType of ImplementationNumberVenue
1Cardiology. CHD. HypertensionClasses1.00E-Studies platform
2Cardiology. Chronic heart failure. Arrhytmias.Classes1.00E-Studies platform
3Pharmacological treatment of arrhythmias. Prevention of thromboembolic events. Pharmacotherapy of inflammatory heart diseases (endocarditis – infectious and rheumatic; pericarditis).Lectures1.00E-Studies platform
4Pulmonology. Asthma. COPD. PneumoniaClasses1.00E-Studies platform
5Clinical pharmacology of agents affecting gastrointestinal system. Pharmacotherapy for increased gastric secretion, peptic ulcer, Gastroesophageal reflux disease (GERD). Pharmacotherapy for gastrointestinal system.Lectures1.00E-Studies platform
6Clinical pharmacology of agents that affect renal function. Pharmacotherapy of main syndromes of kidney damage (nephritic syndrome, nephrotic syndrome). Acute urinary tract infection (cystitis, pyelonephritis, acute urethral syndrome), treatment tactics. Chronic renal disease, pharmacotherapy.Lectures1.00E-Studies platform
7Hypothalamic and pituitary hormone preparations. Clinical pharmacology of medication affecting thyroid gland and parathyroid. Clinical pharmacology of medicines affecting bone mineralization. Vitamin preparations. Clinical pharmacology of drugs used in the treatment of diabetes mellitus. Principles of insulin therapy.Lectures1.00E-Studies platform
8Pharmacology of drugs affecting the adrenal cortex. Steroidal and non-steroidal anti-inflammatory drugs. Disease-modifying anti-rheumatic drugs (DMARD). Anti-gout agents. Spinal spondylosis, disc herniation with root irritation syndrome and pain syndrome, pharmacotherapy. Radiculopathies, their treatment.Lectures1.00E-Studies platform
9Gastroenterology. GERD. Ulcer disease. Nephrology. CKD. Urinary tract infection.Classes1.00E-Studies platform
10Endocrinology. Osteoporosis. Diabetes mellitus. Hypothyreosis.Classes1.00E-Studies platform
11Psychiatry/Neurology. Anxiety. Depression. Epilepsy.Classes1.00E-Studies platform
12Neurology/Rheumatology. Chronic pain. Adaptive, non-adaptive pain. Rheumatoid arthritis.Classes1.00E-Studies platform
Assessment
Unaided Work:
Reports, systematic reviews of specific medications, their application and use in the treatment process.
Assessment Criteria:
Simulation of clinical situations during practical classes, modulation of therapy until a positive result is achieved, assessment – passed / failed. Participation in classes is mandatory, missed classes must be re-worked. Intermediate tests. The average grade of the intermediate tests against the grade received in the exam is 50/50.
Final Examination (Full-Time):Exam
Final Examination (Part-Time):
Learning Outcomes
Knowledge:Describe and explain the principles and pharmacokinetic properties of drug groups and active substances, indications, major adverse reactions, contraindications. Characterize and explain the major interaction risks and effects of drug groups on efficacy, toxicity (if applicable).
Skills:On completion of the study course, students will be able to describe preparations of pharmacotherapeutic groups, formulate their mechanisms of action, indications and contraindications, as well as side effects, justify and base their opinion on the chosen treatment, modulate the applied therapy in different clinical situations. To argue reasonably on the usefulness of a pharmacotherapeutic strategy in cases of particular disease pathology; to critically analyze the usefulness of pharmacotherapeutic strategies in the context of organ system diseases.
Competencies:On completion of the study course, students will be able to: 1. Use theoretical and practical knowledge and competence in clinical pharmacology and the use of medicinal products. 2. Choose the most appropriate medication according to the individual situation in an individualized dosage regimen to ensure optimal patient treatment and disease prevention. 3. Assess the risks and benefits of treatment. 4. Independently obtain, select and analyze information regarding medications, their use and use in the treatment process. 5. Demonstrate a scientific approach to solving topical issues, as well as have good knowledge of specific literature.
Bibliography
No.Reference
Required Reading
1Poisoning & Drug Overdose, 8th ed., 2022
2Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 14th ed., 2022
3RSU E-studiju vide/RSU E-study environment
4Basic & Clinical Pharmacology, 15th ed., 2020
5Medical Pharmacology and Therapeutics, 6th ed., 2022
Additional Reading
1Harrison's Principles of Internal Medicine, 20th ed., 2018
2Basic Concepts in Pharmacology: What You Need to Know for Each Drug Class. 6th ed., 2021
3Dynamed
Other Information Sources
1https://www.drugbank.ca/
2https://pubchem.ncbi.nlm.nih.gov/
3https://accessmedicine-mhmedical-com.db.rsu.lv/updatesConte…
4ClinicalKey