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Infectious Diseases I
Study Course Description
Course Description Statuss:Approved
Course Description Version:7.00
Study Course Accepted:25.03.2022 14:28:06
| Study Course Information | |||||||||
| Course Code: | IUDK_016 | LQF level: | Level 7 | ||||||
| Credit Points: | 8.00 | ECTS: | 12.00 | ||||||
| Branch of Science: | Clinical Medicine; Infectious Diseases | Target Audience: | Medicine | ||||||
| Study Course Supervisor | |||||||||
| Course Supervisor: | Ludmila Vīksna | ||||||||
| Study Course Implementer | |||||||||
| Structural Unit: | Department of Infectology | ||||||||
| The Head of Structural Unit: | |||||||||
| Contacts: | Riga, 3 Linezera Street, idk rsu[pnkts]lv, +371 67014777 | ||||||||
| Study Course Planning | |||||||||
| Full-Time - Semester No.1 | |||||||||
| Lectures (count) | 4 | Lecture Length (academic hours) | 2 | Total Contact Hours of Lectures | 8 | ||||
| Classes (count) | 10 | Class Length (academic hours) | 5 | Total Contact Hours of Classes | 50 | ||||
| Total Contact Hours | 58 | ||||||||
| Full-Time - Semester No.2 | |||||||||
| Lectures (count) | 0 | Lecture Length (academic hours) | 0 | Total Contact Hours of Lectures | 0 | ||||
| Classes (count) | 14 | Class Length (academic hours) | 5 | Total Contact Hours of Classes | 70 | ||||
| Total Contact Hours | 70 | ||||||||
| Study course description | |||||||||
| Preliminary Knowledge: | Anatomy, biochemistry, biology, parasitology, pathologic physiology, microbiology, immunology, pharmacology, propaedeutic, internal diseases. | ||||||||
| Objective: | To provide theoretical and practical knowledge of developmental mechanisms and aetiology of infectious diseases in the human body in correlation with clinical symptoms and possibility of treatment and specific or etiological therapy, as well as of prophylactic methods against infectious diseases, control of spread of infectious diseases, impact on public health and quality of life of each individual. | ||||||||
| Topic Layout (Full-Time) | |||||||||
| No. | Topic | Type of Implementation | Number | Venue | |||||
| 1 | Communicable diseases in a global context – current situation and expectations in future. Infectology in the overall spectrum of diseases. Theoretical and practical basics of infectology, infection process. | Lectures | 1.00 | auditorium | |||||
| 2 | The epidemiology of infectious diseases, epidemic process. The epidemiological investigations, surveillance and control of communicable diseases. | Lectures | 1.00 | auditorium | |||||
| 3 | Diagnostic principles in Infectology: epidemiological, clinical, laboratory – specific and non-specific. | Lectures | 1.00 | auditorium | |||||
| 4 | Principles of treatment in Infectology – specific, etiological, pathogenic and symptomatic therapy, application of principles. | Lectures | 1.00 | auditorium | |||||
| 21 | Organizational principles of Infectios diseases hospital. Rules of transportation and hospitalization of patients with infectious diseases. Medical device reprocessing principles (cleaning, disinfectiopn, sterilization, process control, regulatory documents). | Classes | 1.00 | clinical base | |||||
| 22 | Practical aspects of specific laboratory diagnostics of infectious diseases and evaluationor assessment of obtained results. | Classes | 1.00 | clinical base | |||||
| 23 | Respiratory diseases: viral - influenza, adenovirus infection, rhinosinusitis infection, coronavirus infection, etc., bacterial - pneumococcal infection, legionellosis, whooping cough in adults, diphtheria, mycoplasma and chlamydial infections. Principles of examination and verification of diagnosis. Treatment tactics. | Classes | 1.00 | clinical base | |||||
| 24 | Intestinal infectious diseases: viral - rotavirus, norovirus, coronavirus-induced diseases, etc., bacterial - Salmonella (including S.typhi and S.paratyphi), Shigella, E.Coli, Cl.difficile, Campylobacter, Yersinia, V.cholerae a.o. diseases caused by microorganisms. Food toxic infections, incl. botulism. Clinical picture, principles of diagnosis and treatment. Prophylaxis. | Classes | 1.00 | clinical base | |||||
| 25 | Examination of patients with suspected tuberculosis. Approach to tuberculosis diagnosis. The most common complications of pulmonary tuberculosis and treatment. Tuberculosis infection control. Post primary pulmonary tuberculosis. Tuberculosis in children and immunosuppressed patients. | Classes | 1.00 | clinical base | |||||
| 26 | Process of HIV infection – acute retroviral syndrome, chronic form, clinical manifestations diagnostics, differential diagnosis, principles of treatment. Indicator diseases of HIV infection. AIDS opportunistic infectious diseases. Prophylaxis. Diagnosis, principles of therapy. Patient care. | Classes | 1.00 | clinical base | |||||
| 27 | Algorithm for diagnosis of acute infectious diseases with jaundice (viral, bacterial, protozoan, etc.). Acute viral hepatitis (A, E, B, C herpesviruses, etc.) clinical differences depending on etiology, clinical examination, verification of diagnosis. Chronic viral hepatitis (B, C a.o.). Clinical characteristics, diagnosis verification. Principles of therapy. Bacterial hepatitis - leptospirosis, typhoid, etc. Differential diagnostics. Final results. | Classes | 1.00 | clinical base | |||||
| 28 | Infections caused by Herpes viruses: typical clinical manifestations, differences, differential diagnosis, prevention and treatment options of pathologies caused by HHV1, HHV2, HHV3, HHV4, HHV5, HHV6, HHV7, HHV8. | Classes | 1.00 | clinical base | |||||
| 29 | The most essential human helmintoses – diseases caused by nematodes, cestodes, trematodes. Clinical syndromes, diagnosis, principles of treatment and prevention options. Nematodes, reported in Latvia less commonly. Filariasis. Diseases caused by blood parasites; tropical diseases/ parasitoses typical for tropical areas. Preparation/ getting ready for a travel (special areas, specific groups of patients, specific immunoprophylaxis, etc.). Travel–related health problems after the return. | Classes | 1.00 | clinical base | |||||
| 30 | Viral neuroinfections - tick-borne encephalitis, meningitis caused by epidemic parotitis virus, enteroviruses (including polio virus), herpesviruses, lymphocytic choriomeningitis, West Nile fever, etc. Bacterial neuroinfections - pneumococcal, meningococcal, tuberculous, syphilis - clinical manifestations, investigation, examination of patients, principles of diagnostics and treatment. Meningitis caused by protozoa and fungi. | Classes | 1.00 | clinical base | |||||
| 31 | The most common forms of extrapulmonary TB: Pleural manifestations of tuberculosis, peripheral lymph node TB, bone and joint system TB, miliary TB, central nervous system TB, urogenital TB. | Classes | 1.00 | clinical base | |||||
| 32 | Lyme borreliosis, erlichiosis, Q fever, rickettsiosis a.o. – investigation, verification of diagnosis, treatment principles. Prophylaxis. | Classes | 1.00 | clinical base | |||||
| 33 | Life-threatening infections. | Classes | 1.00 | clinical base | |||||
| 34 | Hemorrhagic fevers – definition, classification, etiologic groups, clinical manifestations, verification of diagnosis, principles of treatment. Currently topical exotic diseases - Ebola fever, Zika virus disease. Dengue fever. Emergency conditions in the context of infectious diseases. | Classes | 1.00 | clinical base | |||||
| 35 | Systemic and opportunistic mycoses - epidemiology, etiology, pathogenesis, pulmonary and extrapulmonary manifestations. Sarcoidosis. Psittacosis and other currently topical zoonoses of the world. | Classes | 1.00 | clinical base | |||||
| 36 | Adult vaccination: aims and objectives; indications and contraindications; practical aspects of vaccination. Immunoglobulins, serum. Malaria prevention. Tetanus. Traveler Diseases. | Classes | 1.00 | clinical base | |||||
| 37 | Microbiological criteria for food and environmental objects and organisation of laboratory control as the prevention of infectious diseases. | Classes | 1.00 | clinical base | |||||
| 38 | The course of SARS CoV-2 infection - from etiology to the end result. | Classes | 1.00 | clinical base | |||||
| 39 | Infections of bones and joints - diagnostics, treatment, prevention. | Classes | 1.00 | clinical base | |||||
| 40 | Principles of immunity development in infectious diseases. | Classes | 1.00 | clinical base | |||||
| 41 | Antimicrobial resistance. Multi-resistant microflora, its role in the patient care of nosocomial infections. The impact of hospital-acquired infections on the design of infectious diseases in future. | Classes | 1.00 | clinical base | |||||
| 42 | Peculiarities of infectious diseases, including tuberculosis, in the context of geriatrics. | Classes | 1.00 | clinical base | |||||
| 43 | Diagnostics of infectious diseases characterized by lymphadenopathy, differential diagnostics with non – infectious pathologies Infectious diseases manifesting as rash - diagnostics and differential diagnostics in adults. | Classes | 1.00 | clinical base | |||||
| 44 | The known and unknown in the context of infectious diseases. Questions, answers, discussions on all course topics. | Classes | 1.00 | clinical base | |||||
| Assessment | |||||||||
| Unaided Work: | 1. Preliminary preparation for each practical class (relevant topic); 2. Independent study report (the 7th semester); 3. Case report (the 8th semester). | ||||||||
| Assessment Criteria: | Independent work: 1. Independent study report: assessment criteria – compliance of the content of the report with the selected topic; design of the report; student’s individual input, contribution or work invested; level of student’s knowledge evaluated by the lecturer (responsible for the group) when discussing the individual study report with the student. 2. Case report – report task comprehension, use of a virtual fact summary for diagnosis detection (laboratory test, instrumental investigation, anamnesis, including epidemiological data, etc.), the logic of the diagnostic reasoning and the range of differential diagnosis coverage, therapeutic, prophylactic, suggestions etc. Test in the 7th semester - practical class attendance, evaluation of Individual Study Report; Examination in the 8th semester - practical class attendance and evaluation of a clinical case - 50%, written exam (50%), which consists of a theoretical question (20%) on the acquired topic and interpretation of one clinical case (30%). | ||||||||
| Final Examination (Full-Time): | Exam (Written) | ||||||||
| Final Examination (Part-Time): | |||||||||
| Learning Outcomes | |||||||||
| Knowledge: | Students will be able to describe and classify infectious diseases according to etiological factor, prevailing symptoms, type of spread, levels of disease severity, hazard to public health and each individual; to identify and describe specific, typical, pathogenetic and other symptoms; to explain the programme or plan of investigations and systematize the methods; to define and explain general principles of treatment; to define steps of health care plan for individual treatment/to relate steps of health care plan to individual treatment; to describe and comment on current principles of specific prophylaxis, applying them on public health level as well as to each individual patient. | ||||||||
| Skills: | The students will be able to develop an action plan for diagnosis and treatment of the disease of the patient; to implement the created plan based on collected anamnesis and data obtained from laboratory tests and other investigations; to evaluate data of physical examination of the patient; the students will be competent to integrate results of laboratory investigations in the design of disease diagnostics; to plan prevention activities in order to control the spread of disease. | ||||||||
| Competencies: | To apply basic knowledge and skills of reasoning, logics and public speaking in order to analyse situations in practical infectology, to discuss and explain personal viewpoint/opinion and constructively promote achievement of professional goals and specific tasks in order to provide individual and public health care; to communicate successfully with patients, their relatives and medical professionals as regards diagnostics, differential diagnosis, prevention and treatment of infectious diseases; to provide patient care in cooperation with patients, their relatives and medical experts, while respecting patients’ rights and norms of medical ethics; to study independently and use e-health medical resources for communication with other students and colleagues; to demonstrate and improve personal professional skills and develop oneself as a potential health care provider and promoter in the context of specific and non-specific prophylaxis of the infectious diseases. | ||||||||
| Bibliography | |||||||||
| No. | Reference | ||||||||
| Required Reading | |||||||||
| 1 | Bennett J. E., Dolin R., Blaser M.J. 2020. Mandel l Douglas and Bennett's Principles and Practice of Infectious Diseases, 9th ed. Elsevier | ||||||||
| 2 | Vīksna L. Infekcijas slimības. Rīga: Medicīnas apgāds; 2011. | ||||||||
| 3 | Maxine A. Papadakis, Stephen J. McPhee, Michael W. Rabow Lange.2022. Current Medical Diagnosis and Treatment.61th.ed. USA: McGraw Hill. Access Medicine. Iegūts no: via Access Medicine | ||||||||
| 4 | Ferri's. 2022. Clinical Advisor Elsevier. ClinicalKey. Iegūts no via: ClinicalKey | ||||||||
| 5 | Zeltiņa I., Zavadska D, Grope I., Aldiņš P., Savrasova L., Grāmatniece A., Žilde A. 2019. Praktiskas rekomendācijas vakcinācijai veseliem pieaugušajiem un riska grupu indivīdiem Latvijā. Rīga. Slimību profilakses un kontroles centrs Pieejams tiešsaistē: https://www.spkc.gov.lv/lv/rekomendacijas-bernu-un-pieaugus… | ||||||||
| 6 | Cilvēka imūndeficīta vīrusa (HIV) infekcijas diagnostikas, ārstēšanas un profilakses klīniskās vadlīnijas. 2014 Pieejams tiešsaistē: https://www.spkc.gov.lv/lv/registretas-2014gada/5322e63b987… | ||||||||
| 7 | EASL recommendations on treatment of hepatitis C: Final update of the series.2020.Journal of Hepatology. 73 (5). ScienceDirect. Available from: https://www.sciencedirect.com/science/article/pii/S01688278… | ||||||||
| 8 | European AIDS Clinical Society Guidelines Version 10.1 October 2020. https://www.eacsociety.org/media/guidelines-10.1_30032021_1 .pdf | ||||||||
| 9 | EACS quidelines European AIDS clinical society 2021. Pieejams tiešsaistē: https://www.eacsociety.org/guidelines/eacs-guidelines/ | ||||||||
| 10 | Tuberkulozes klīniskās vadlīnijas. 2015. Pieejams tiešsaistē: https://www.spkc.gov.lv/lv/registretas-2015gada/551a46b722f… | ||||||||
| 11 | Madhukar Pai, Marcel A. Behr, David Dowdy, et.al. 2016. Tuberculosis. Nature reviews. 27October.PubMed. Available from: https://www.nature.com/articles/nrdp201676 | ||||||||
| 12 | Goldman L., Schafer A.2020. “Goldman-Cecil Medicine”, 26th ed. Elsevier Inc. ClinicalKey. Iegūts no: via ClinicalKey | ||||||||
| 13 | Luigi Nibali; Brian Henderson ed.2016. The Human Microbiota and Chronic Disease: Dysbiosis as a Cause of Human Pathology. Wiley-Blackwell. Ebsco. Iegūts no via: Ebsco | ||||||||
| 14 | CDC Yellow Book 2018: Health Information for International Travel, Oxford University Press Pieejams tiešsaistē: https://academic.oup.com/cid/article/66/7/1157/4774649 | ||||||||
| 15 | L.Vīksna, I.Tolmane un autoru kolektīvs. 2021.Rekomendācijas par SARS-CoV-2 infekcijas un COVID-19 epidemioloģiju, diagnostiku, klīniskajām norisēm un komplikācijām. Valsts pētījumu programma. Rīga. Pieejams tiešsaistē: https://www.spkc.gov.lv/sites/spkc/files/media_file/covid_1… | ||||||||
| 16 | Coronoviruses disease 2019-(COVID-19) treatment quidelines 2021. Available from: https://www.semergen.es/files/docs/COVID-19/Documentos/covi… | ||||||||
| 17 | Edward T Ryan, David R Hill, Tom Solomon, Naomi Aronson, Timothy P Endy. 2020. Hunter's Tropical Medicine and Emerging Infectious Diseases, 10th ed, Elsevier ClinicalKey. Iegūts no: via ClinicalKey | ||||||||
| 18 | Jay Keystone, Phyllis Kozarsky, Bradley Connor, Hans Nothdurft, Marc Mendelson, Karin Leder. 2019. Travel Medicine, 4th ed. Elsevier. ClinicalKey. Iegūts no: via ClinicalKey | ||||||||
| 19 | Izakovicova P, Borens O, Trampuz A. Periprosthetic joint infection: current concepts and outlook. 2019. EFORT Open Rev Jul 29;4(7):482-494. PubMed. Available from : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667982/ | ||||||||
| 20 | Steinmetz S, Wernly D, Moerenhout K, Trampuz A, Borens O. Infection after fracture fixation. 2019. EFORT Open Rev. Jul 15;4(7):468-475. PubMed. Available from : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667977/ | ||||||||
| 21 | Oshsner PE, Borens O, Bodler PM. 2016. Infections of the musculoskeletal system. Basic principles, prevention, diagnosis and treatment. 1st ed. Published by Swiss orthopaedics and the Swiss Society for Infectious Diseases expert group „Infections of the musculoskeletal system” Available from: https://www.heraeus.com/media/media/hme/doc_hme/infection_b… | ||||||||
| Additional Reading | |||||||||
| 1 | Solomon T et al. 2012. Management of suspected viral encephalitis in adults-Association of British Neurologists and British Infection Association National Guidelines. J.Infect .64(4):347-73. PubMed. Available from : https://pubmed.ncbi.nlm.nih.gov/22120595/ | ||||||||
| 2 | Baldwin, K. J., & Zunt, J. R. (2014). Evaluation and Treatment of Chronic Meningitis. The Neurohospitalist, 4(4), 185–195. PubMed. Available from: https://pubmed.ncbi.nlm.nih.gov/25360204/ | ||||||||
| 3 | EASL Recommendations on Treatment of Hepatitis C 2018.Journal of Hepatology 69(2):461-511. PubMed. Available from : https://pubmed.ncbi.nlm.nih.gov/29650333/ | ||||||||
| 4 | EASL Clinical Practice Guidelines For The Management of Patients With Decompensated Cirrhosis.2018. Journal of Hepatology.69( 2), 406-460. ScienceDirect. Available from: https://www.sciencedirect.com/science/article/pii/S01688278… | ||||||||
| 5 | EASL Clinical Practice Guidelines On Hepatitis E Virus Infection.2018. Journal of Hepatology.68(6):1256-1271. ScienceDirect. Available from : https://www.sciencedirect.com/science/article/pii/S01688278… | ||||||||
| 6 | EASL Clinical Practice Guidelines: Management Of Alcohol-Related Liver Disease 2018.Journal of Hepatology.69(1): 134-181.ScienceDirect. Available from: https://www.sciencedirect.com/science/article/pii/S01688278… | ||||||||
| 7 | EASL 2017 Clinical Practice Guidelines on The Management of Hepatitis B Virus Infection.2017. Journal of Hepatology.67(2):370-398. ScienceDirect. Available from: https://www.sciencedirect.com/science/article/pii/S01688278… | ||||||||
| 8 | Sulis G., Centis R., Sotgiu G. et al.2016. Recent developments in the diagnosis and management of tuberculosis. NPJ Primary Care Respiratory Medicine. 26, 16078. PubMed. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093435/ | ||||||||
| 9 | Dheda K., Gumbo T., Maartens G. et al.2019. The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis. The Lancet Respiratory Medicine. 79(90: 820-826.ClinicalKey. Available from: https://www-clinicalkey-com.db.rsu.lv/#!/content/journal/1-… | ||||||||
| 10 | Laimborelioze. Diagnostikas un ārstēšanas klīniskās rekomendācijas pieaugušajiem. 2020. Latvijas Infektologu, Hepatologu un HIV/AIDS speciālistu asociācija. Slimību profilakses un kontroles centrs. Pieejams tiešsaistē: https://www.spkc.gov.lv/sites/spkc/files/content/Iedzivotaj… | ||||||||
| Other Information Sources | |||||||||
| 1 | https://accessmedicine.mhmedical.com | ||||||||
| 2 | https://www.clinicalkey.com | ||||||||
| 3 | http://site.ebrary.com/lib/rsub | ||||||||
| 4 | http://search.ebscohost.com/ | ||||||||
| 5 | http://www.who.int/ | ||||||||
| 6 | www.uptudate.com | ||||||||
| 7 | https://www.ean.org/ENCEPHALITIS-VIRAL-MENINGOENCEPHALITIS-… | ||||||||
| 8 | https://ecdc.europa.eu/sites/ | ||||||||
| 9 | https://ecdc.europa.eu/en/news-events | ||||||||
| 10 | https://www.ncbi.nlm.nih.gov/pubmed/ | ||||||||
| 11 | https://www.ncbi.nlm.nih.gov/books/ | ||||||||
| 12 | https://emedicine.medscape.com/ | ||||||||
| 13 | https://www.cdc.gov/ | ||||||||
| 14 | http://www.antimicrobe.org/ | ||||||||
| 15 | https://www-amboss-com.db.rsu.lv/row/campus/2018/rsu-activa… | ||||||||
| 16 | http://www.dynamed.com/ | ||||||||
| 17 | http://www.merckmanuals.com/ | ||||||||
| 18 | https://aricjournal.biomedcentral.com/articles/ | ||||||||
