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The Joint Laboratory of Clinical Immunology and Immunogenetics is able to provide a wide spectrum of services in the field of laboratory diagnostics and immunogenetics.

The Joint Laboratory of Clinical Immunology and Immunogenetics:

  • carrie out scientific research activities in the field of immunology, immunogenetics and medicine, developing applied and fundamental research in order to promote science and higher education;
  • participates in the education of clinical immunologists, laboratory doctors and laboratory specialists in the field of immunology;
  • provides postgraduate training for specialists whose immunology is a core part of the specialty (laboratory doctors who use immunological methods in oncoimmunology, rheumatology, dermatology, transfusiology, immuno-neurology, transplantology, immune-deficiency immunology, etc.);
  • performs polymerase chain reaction (PCR) (HLA genotyping, microbiological testing of clinical material), serology testing of blood by ELISA method.

Research directions

  • Infections and autoimmune diseases, the impact of HLA class I, II, III alleles on disease progression and treatment response
  • Bioinformatic study of HIV epitopes on the surface of antigen-presenting cells in HLA class II genes
  • Drug resistance during immune response
  • Clinical applications and research of MHC (Major Histocompatibility Complex)

Projects

  • RSU/RTU collaboration project No13073 “Creation of nanostructured bone replacement materials and study the immunological aspects of bone regeneration”
    Duration: 2015–2020
  • RSU Projekta No. 2019/1-0069 "HLA class II alleles, cytokine levels, and ORAI1 and STIM1 gene expression in blood for prognose delayed sputum culture conversion in patients with pulmonary tuberculosis"
  • RSU research project. No. 21-1/1/2019-3: Differences in biochemical and immunogenetic markers of apoptosis and fibrosis and endotoxins in patients with immunosuppressive RNA virus (HIV, HCV) -related infections and association with infection severity (in collaboration with Infection diseases Department)
    Duration: 2019–2020

  • RSU student projects: Non-invasive diagnostics of cytomegalovirus infection in patients with ulcerative colitis at Children's Clinical University Hospital and Riga Eastern Clinical University Hospital. Student research work.
    Duration: 2019–2020

  • GRP Biomedical Public Health Project No.5. Subproject no. 7.1. Development of innovative strategies to regulate and modulate the infection process
    Duration: 2019–2020
  • COST Action BM1406 2020, Ion Channels and Immune Response toward a global understanding of immune cell physiology and for new therapeutic approaches (IONCHAN-IMMUNRESPON)
    Duration: 2016–2020

Publications

2019

Articles in internationally cited journals

  1. L. Bara, J. Eglite, P. Oss, V. Cauce, E. Hagina, S. Gintere, L. Viksna, and A. Krumina. Development of sepsis in relation to serum biomarkers concentration like intercellular adhesion molecule-1, macrophage migration inhibitory factor, plasminogen activator inhibitor-1 and soluble Fas ligand. Clin. Pract. (2019) 16(S1), 1361-1367.DOI: 10.4172/clinical-practice.1000402.
  2. L. Viksna, M. Vilcans, I. Zeltiņa, A. Leidere-Reine, A. Krumiņa, O. Koļesova, J. Ļeviņa, A. Koļesovs. Vaccination against influenza: Attitude of health care personnel in a multidisciplinary hospital in Latvia. Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences,Volume 73, Issue 4, 1 August 2019, Pages 403-406
  3. L. Bara, J. Eglite, P. Ošs, V. Cauce, V. Lietuvietis, L. Viksna, E. Hagina, A. Krumina. HLA Class II-DRB,-DQA and-DQB genotypes in peripheral blood shows shifts during the course of sepsis. Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, 73 (1), pp. 10-16. DOI: 10.2478/prolas-2019-0002
  4. K. Kramiča, J. Eglite, A. Kolesovs, T. Kramica, G. Titovica, D. Dzerina, G. Nikolajeva, L. Viksna, O. Koļesova. A pilot study on markers of genetic predisposition in tuberculous pneumonia patients in Latgale. Journal Proceedings of the Latvian Academy of sciences. Section B. Vol 73 Latvia,1-3April  (2019), No 2,189-191.
  5.  V. Jasinskis, O. Kolesova, A. Kolesovs, L.Viksna, I. Azina, B. Rozentale , J. Eglite. Human Leukocyte Antigens Class II alleles impacting the response to 5-7 year antiretroviral therapy in a Latvian cohort. Journal Proceedings of the Latvian Academy of sciences. Section B. Vol 73 (2019), No 2, 84-88.
  6. S. Laivacuma, J. Eglīte, A. Derovs, and L. Vīksna. Distribution of HLA allele frequencies in patients with cystic and alveolar echinococcosis in Latvia. Proceedings of the Latvian. Academy of Sciences. Section B. Vol.73(2019), No. 4(721), pp. 296-303.
  7. O. Koļesova, J. Eglīte, A. Koļesovs, A. Krūmiņa, I. Ekšteina, M. Madelāne, and L. Vīksna. Association of non-invasive markers of liver fibrosis with HCV coinfection and antiretroviral therapy in patients with HIV. Proceedings of the Latvian. Academy of Sciences. Section B. VoL.73(2019), No. 4 (721), pp. 400-402.

Abstracts

  1. L. Bara, J. Eglite, P. Oss, V. Cauce, S. Gintere, L.Viksna, A. Krumina. Intercellular adhesion molecule-1, macrophage migration inhibitory factor and plasminogen activator inhibitor-1 relationship to sepsis clinical severity. Latvia. Rīga Stradiņš University International Conference on Medical and Health Care Sciences Knowledge for Use in Practice 2019. pp. 231.
  2. S. Laivacuma, L. Viksna, J. Eglite. Liver echinococcosis-how can immunogenetic tests improve diagnosis and management tactics. Rīga Stradiņš University International Conference on Medical and Health Care Sciences Knowledge for Use in Practice 2019. pp. 227.
  3. O. Plisko, J. Zorzika, D. Rezeberga, I. Jermakova, J. Eglīte, D. Kasjko. Association between human leukocyte antigen genes and cervical precancerous lesions. Rīga Stradiņš University International Conference on Medical and Health Care Sciences Knowledge for Use in Practice 2019 pp 69.
  4. V. Jasinskis, O. Kolesova, A. Kolesovs, L.Viksna, I. Azina, B. Rozentale , J. Eglite . Human Leukocyte Antigens Class II alleles impacting the response to 5-7 year antiretroviral therapy in a Latvian cohort. Rīga Stradiņš University International Conference on Medical and Health Care Sciences Knowledge for Use in Practice 2019. pp.195.
  5. K. Kramica, J. Eglite, O. Kolesova, A. Kolesovs, T. Kramica, G. Titovica, D. Dzerina, G. Nikolajeva, L. Viksna. Markers of Genetic Predisposition in Tuberculous Pneumonia Patients in Latgale, Latvia. Rīga Stradiņš University International Conference on Medical and Health Care Sciences Knowledge for Use in Practice 2019. pp. 220.
2018

Patents

  1. Patents LV 15270 B. J.Eglīte, O. Kolesova, A. Kolesovs,V. Jasinskis, E. Hagina, I. Januškeviča, G. Stūre, K. Kramiča, B. Rozentāle, J. Storoženko, L. Vīksna. Method of predicting the risk of sudden death in patients with dual co-infection with HIV and tuberculosis (HIV / TB), including IRIS
  2. Patents LV Nr. 15269 B. J. Eglīte, V. Staņēviča, M. Višņevska, , O. Kolesova at al.  Method for determining the risk of developing juvenile idiopathic rapidly progressive oligoarthritis in children six months before clinical signs.20.05.2018.
  3. Patents LV 15235 B. Inventors (LV): J. Eglite, D. Kasjko, V. Jasinskis, E. Hagina, I. Januškeviča, G. Stūre, B. Rozentāle, J. Storoženko, L. Vīksna. Prediction of HIV risk in women. 20.05.2018.

Articles in internationally cited journals

  1. S. Laivacuma, J. Eglīte, A. Derovs, and L. Vīksna. Distribution of HLA allele frequencies in patients with cystic and alveolar echinococcosis in Latvia. Experimental and Clinikal Gastroenterilogy. 2018;159(11):14-18. (in Russ) DOI:10.31146/1682-8658-ecg-159-11-14-18
  2. L. Vīksna, S. Laivacuma, L. Zaharova, J. Eglīte u. c. Praktiskie ieteikumi ehinokokozes diagnostikai un ārstēšanai. I medicus bonus, Nr. 36, lpp. 18-23, 01.07.2018.g.
  3. V. Skuja, A. Derovs, K. Pekarska, D. Rudzite, E. Lavrinovica, L. Piekuse, I. Kempa, Z. Straume, J. Eglite, A. Lejnieks, A. Krumina, R. Eliakim. Gut colonization with extended-spectrum ß-lactamase-producing Enterobacteriaceae may increase disease activity in biologic-naive outpatients with ulcerative colitis: an interim analysis. European Journal of Gastroenterology & Hepatology: January 2018, Vol. 30 - Issue 1, p 92-100. DOI: 10.1097/MEG.0000000000000989

Abstracts

  1. O. Koļesova, V. Jasinskis, E. Hagina, I. Ažiņa, B. Rozentāle, K.Kramiča, J. Eglīte. The association of IFN-y production with the level of ORAL1 gene expression in patients  with HIV- associated tuberculosis (Pilot Study) COST Seillac meeting Action BM1406, abstract book 2018,WG2 (diseases) :14.
  2. M. Visnevska, V. Stanevica, J. Eglite, V. Rovite, Z. Davidsone, A. Scegolevs, R. Santere. Molecular genetic studies of human leukocyte antigen (HLA) class II alleles and clinical profile of acute rheumatic fever in Latvia. Pediatric Rheumatology 2018, 16(Suppl 2):52 , B14:222. https://doi.org/10.1186/s12969-018-0265-6.
  3. L. Bridina, S. Silina, J. Eglite, A. Krumina. Determination of HLA-DRB1,-DQA1 and–DQB1 alleles freguency in sepsis patients. www.isid.org/icid. 2018.
  4. K. Kramiča, O. Koļesova, J. Eglīte, S. Koļesovs, T. Kramiča, G. Titoviča. Ģenētiskās predispozīcijas marķieri pacientiem ar tuberkulozes pneimoniju Latgales reģionā. RSU zinātniskā konference, 2018. g. 22.-23.03., tēzes, 4. lpp.
  5. I. Ažiņa, J. Eglīte, E. Hagina, A. Šangirejeva, J. Storoženko, T. Kolupajeva, L. Guseva, B. Rozentāle. Plazmas citokīnu (IFN-g, IL-1β, IL-10 un IL-18) līmeņa asociācija ar exitus letalis pacientiem ar HIV-1 un tuberkulozes duālo infekciju. RSU zinātniskā konference, 2018. g. 22.-23.03., tēzes, 5. lpp
2017

Inventions

  1. J. Eglīte, J. Kasjko, V. Jasinskis, E. Hagina, I. Januškeviča, G. Stūre, B. Rozentāle, J. Storoženko, L. Vīksna. Ar HIV inficētam mātes intrauterīnas augļa HIV inficēšanās prognozēšanas paņēmiens pirmajos sešos grūtniecības mēnešos: LV 15133 B: patents. Pieteikts: 09.03.2016; publicēts: 20.01.2017. Izgudrojumi, Preču Zīmes un Dizainparaugi. Nr. 1 (2017), 6. lpp.  

International journals

  1. I. Azina, J. Eglite, O. Kolesova, A. Kolesovs, J. Storozenko, G. Sture, E. Hagina, B. Rozentale, A. Lejnieks. The relationship between HLA class II alleles and immunological status of patients with HIV-assosiated tuberculosis in Latvia. World Journal of Pharmaceutical and Medical Research. Vol. 3, Issue 2 (2017, March), p. 27–32.
  2. Kolesova O., Kolesovs A., Vetra J. Age-Related Trends of Lesser Pelvic Architecture in Females and Males: a CT pelvimetry study. Anatomy and Cell Biology, Vol. 50, No. 4, 2017, p. 34–40.
  3. S. Skribāne, L. Bajāre, O. Koļesova. The anatomical characteristics of n. trigeminus blockade sites. Proceeding of the 59th International Scientific Conference of Daugavpils University (Daugavpils 2017, 6–7 april) p. 515–519.

Abstracts

  1. Z. Davidsone, E. Eglite, A. Kolesovs, R. Santere, V. Stanevica. HLA II class alleles in juvenile idiopathic arthritis patients with and without chronic arthritis signs in temporomandibular joints evaluated with contrast enhanced MRI. Pediatric Reumatology. Vol. 15, Suppl. 2 (2017), p. 35.
  2. I. Ažiņa, J. Eglīte, E. Hagina, J. Storoženko, B. Rozentāle, A. Lejnieks. HLA II klases gēnu polimorfisma saistība ar imunoloģiskā statusa rādītājiem pacientiem ar HIV asociēto tuberkulozi Latvijā. RSU zinātniskā konference, 2017, tēzes, 5. lpp.
  3. I. Ažiņa, J. Eglīte, G. Stūre, J. Storoženko, O. Koļesova, T. Kolupajeva, L. Guseva, B. Rozentāle. Homozigotāte HLA-DQB1 lokusā un tās negatīvā ietekme uz HIV-1 un tuberkulozes koinfekcijas gaitu. RSU zinātniskā konference, 2017, tēzes, 4. lpp.
  4. O. Koļesova, J. Eglīte, I. Ažiņa, B. Rozentāle. IFN-γ produkcijas saistība ar ORAI1 gēna ekspresijas līmeni pacientiem ar HIV asociēto tuberkulozi (pilotpētījums). RSU zinātniskā konference, 2017, tēzes, 7. lpp.
  5. S. Laivacuma, J. Eglīte, L. Vīksna. Risk fectors of echinococcosis in Latvia. 7th Conference of the Scandinavian-Baltic Society for parasitology (Riga, Latvia, June 8–9, 2017): Abstracts, p.27.
  6. O. Kolesova, J. Eglite, I. Azina, B. Rozentale. Negative impact of homozygosity in HLA-DQB1 locus on HIV-associated tuberculosis. 47th Annual Meeting of the German Society for Immunology, Erlangena, 2017, tēzes, 90. lpp.
  7. Bridina L., Gintere S., Mikule L., Eglīte J., Krumina A. Relationship of Blood Planting Gram-positive and Gram-negative Bacteria with Procalcitonin and C-reactive protein in Serum of Sepsis Patients. RSU zinātniskā konference, 2017, tēzes, 23. lpp.
  8. Eglite J., Jasinskis V., Hagina E., Kolesova O., Kasjko D., Locs J., Vectaudza J., Rubenis K. A Systematic review on the use of immune system involvement in bone reconstitution using hydroxyapatite (HAp). European Advanced Materials Congress (EAMC) (Stockholm, Sweden, Aug. 22–24, 2017). www.vbripress.com/eamc, DOI:10.5185/eamc.2017
  9. Eglite J., Jasinskis V., Hagina E., Kolesova O., Kasjko D. Theretical Foundation for the Use of Hydroxyapatite (HAp) for Bone Repairs. RSU zinātniskā konference, 2017, tēzes, 44. lpp.
  10. S. Skribāne, L. Bajāre, O. Koļesova. The anatomical characteristics of n.trigeminus blockade sites. Abstracts  of the 59th International Scientific Conference of Daugavpils University(Daugavpils 2017, 6–7 april) p. 98–99.
2016
  1. Z. Dāvidsone, J. Eglīte, A. Lazareva, S. Dzelzīte, R. Šantere, D. Bērziņa, V. Staņēviča HLA II class alleles in juvenile idiopathic arthritis patients with and without temporomandibular joint arthritis. Pediatr Rheumatol Online J. 2016 Apr 19;14(1):24. doi: 10.1186/s12969-016-0086-4.
  2. J. Eglite, .I.Golushko, E. Urtans, I. Januskevica and B. Rozentale. Association of Tumor Necrosis Factor-α (TNFα) Gene Polymorphisms with HLA Class II Alleles in HIV/AIDS Patients British Journal of Medicine & Medical Research 13(12): 1-10, 2016.,NLM ID 101570965.
  3. I. Januškevica, B. Rozentāle, E. Hagina, J. Eglīte, T. Kolupajeva, J. Storozenko, L. Guseva, and A. Lejnieks. Role of Interferon-Gamma (IFN-y) in immune response regulation in HIV-1 and HIV-1 + mycobacterium tuberculosis (TB) infected patients. Proceeding of Latvian Academy of Sciences. Section B, Vol. 70 (2016), pp. 211-214.
  4. I. Januskeviča, A. Sangirejeva, J. Eglīte, E. Hagina, V. Jasinskis, J. Storozenko, A. Lejnieks and B. Rozentale. Trends in Tuberculosis/Human Immunodeficiency Virus Comorbidity, Latvia, 2012-2014. Journal of Scientific Research& Reports 9(5):1-7,2016;DOI: 10.9734/JSRR/2016/22247.
  5. L. Kovalchuka, S. Cvetkova, J. Trofimova, J. Eglite, S. Gintere, I. Lucenko, B. Oczko-Grzesik, L. Vīksna, and A. Krumina. Immunogenetic Markers Definition in Latvian Patients with Lyme Borreliosis and Lyme Neuroborreliosis. International Journal of Environmental Research and Public Health 2016, 13, 1194; doi:10.3390/ijerph13121194.
  6. L. Kovaļčuka, J. Eglite, M. Zālīte, I. Lucenko, L. Vīksna and A. Krūmiņa. Immunogenetic manifestations of lyme borreliosis . Proceeding of Latvian Academy of Sciences. Section B, Vol. 70 (2016), pp. 215-219.
2015
  1. I. Januškeviča, A. Sangirejeva, J. Eglīte, E. Hagina, V. Jasinskis, J. Storozenko, A. Lejnieks and B. Rozentale. Trends in Tuberculosis/Human Immunodeficiency Virus Comorbidity, Latvia, 2012.-2014. Journal of Scientific Research& Reports 9(5):1-7, 2016. Article no JSRR.22247 ISSN:2320-0227.
2014
  1. E. Eglite, E. Hagina, J. Pavare, I. Grope, L. Eihvalde, A. Sochnevs and D. Gardovska. Genetic Polymorphisms HLA Class II in SIRS and Sepsis in Children. British Journal of Medicine and Medical Research. 4(1):149-160. 2014.
  2. V. Jasinskis, D. Kasjko , E. Eglite, G. Sture , L. Viksna, B. Rozentale, A. Sochnevs, Comparison of Antiretroviral Therapy (ART) Efficiency and Different HLA Class II Haplotypes, British Journal of Medicine & Medical Research 4(7): 1473-1482. March,2014.g.
  3. D.  Kasjko., V.  Jasinskis., E. Dobele., L. Kovaļčuka., J. Eglīte., A. Sočņevs., G. Stūre., L. Vīksna. DRB1*01:01 gēna mutācijas izpēte 2.eksonā HIV/AIDs slimniekiem. RSU Zinātniskie raksti 2013, 2013. gada medicīnas nozares pētnieciskā darba publikācija, 2014 – 337.–344.
  4. D. Kasjko, V. Jasinskis, E. Eglite, L. Kovalchuka,Elina Dobele, G. Sture, A. Sochnevs, and L. Viksna. Mutations in HLA DRB1*0101 Exon 2 in a Sub-population of Latvia. British Journal of Medicine & Medical Research 4(4): 981-989. 2014
  5. D. Kasjko, V. Jasinskis , E. Eglite, J.Golushko, G. Sture, A. Kalimulin, A. Sochnevs, and L. Viksna. Research of HLA II class DRB1, DQA1, DQB1 genetic markers in patients with HIV infection and AIDS. British Journal of Medicine & Medical Research 4(27): 4482-4500, 2014.
  6. L. Kovalchuka, J. Eglite, M. Zalite, I.Lucenko, I. Logina, G. Karelis, L. Viksna, A. Krumiņa. The frequency of HLA-DR alleles in patients with Tick-borne disease from Latvia. Res J Infect Dis 2014. ISSN:2052-5958. Volume 2, Article 4, doi: 10.7243/2052-5958-2-4.
  7. A. Krumina, G. Vasiljeva, A. Ivanovs, S. Gintere,  L. Kovalchuka, S. Rasa, S. Chapenko, M. Murovska, L.Viksna and I. Logina. Assessment of  Value of Fatigue Severity and Symptoms in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Fibromyalgia. British Journal of Medicine & Medical Research 4(36): 5866-5877, 2014.     ISSN:2231-0614. Pub. date: 26.august 2014.
  8. L. Viksna, A. Jeruma, J. Eglite, A. Sočņevs, and V. Sondore. Biochemical and Immunogenetic Diagnostic Markers Less Commonly Used for Predicting the Efficacy of Chronic Hepatitic C Etiotropic.Therapy.Virology&Mycology,ISSN:2161-0517 VMID, an open access journal. Pub. date: May 08,2014.

 

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