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The Joint Laboratory of Clinical Immunology and Immunogenetics is capable of providing a comprehensive range of services in laboratory diagnostics and immunogenetics.

The Joint Laboratory of Clinical Immunology and Immunogenetics:

  • Conducts scientific research in the areas of immunology, immunogenetics and medicine, performing applied and fundamental research aimed at facilitating scientific activity and higher education;
  • Trains new specialists  - immunologists, laboratory physicians and assistants in the area of immunology;
  • Provides post-diploma training for immunologists and other specialists having immunology as part of their main specialty (laboratory physicians working with immunological methods for tumor immunology, rheumatology, dermatology, transfusiology, immunonephrology, transplantology, immunodeficiency in immunology etc.).
  • Applies polymerase chain reaction (PCR) - HLA genotyping for microbiological testing of clinical material, serologic testing and scientific activity;
  • Provides qualified consultative and diagnostic assistance to the local population in all areas of clinical immunology. 

Research directions

  • Infections and autoimmune diseases, the impact of HLA class I, II, III alleles on disease progression and treatment response
  • Bioinformatic study of HIV epitopes on the surface of antigen-presenting cells in HLA class II genes
  • Drug resistance during immune response
  • Clinical applications and research of MHC (Major Histocompatibility Complex)

Projects

Grants by the Latvian Council of Science
  • Collaboration programmes of the Latvian Council of Science: No. 09.1402. “Specific, immunogenetics, biochemical, clinical, radiological differential diagnosis of acute and chronic borreliosis (Lyme disease), projections of the course of the disease, patient life quality verification for the prophylaxis of disability caused by borreliosis and reduction of the burden on community health in Latvia.”
    Duration: 2009–2012
  • Collaboration programmes of the Latvian Council of Science: No. 10.0029 “Innovative approaches in the research of molecular-genetic features of micro-organisms and systematic damage mechanisms related to it, as well as in the elaboration of individual infectious disease supervision, diagnostics and therapy methods and techniques” (leading prof. L. Vīksna) in sub-project: No. 10.0029.5. “MHC/HLA genes and the role thereof in the etiopathogenesis; genetic forecast of disease progress and therapy efficiency”.
    Duration: 2010–2013
  • Collaboration programmes of the Latvian Council of Science: No. 10.0010.09. “Chromosome 6p21.3 MHC/HLA region genotyping and immunoregulatory gene nucleotide sequence of the second exon and prognostic criteria determination in the case of HIV infection.”
    Duration: 2010–2013

  • Project of the Latvian Council of Science: No. 09.1604. “Specific, immunogenetics, biochemical, clinical, radiological differential diagnosis of acute and chronic borreliosis (Lyme disease), projections of the course of the disease, patient life quality verification for the prophylaxis of disability caused by borreliosis and reduction of the burden on community health in Latvia.”
    Duration: 2009–2012

Projects financed by other international institutions
  • COST programme: No. BM0803 “A European network of the HLA diversity for histocompatibility, clinical transplantation, epidemiology and population genetics (HLA-NET)”
    Duration: 2009–2013

Publications

2017

Inventions

  • J. Eglīte, J. Kasjko, V. Jasinskis, E. Hagina, I. Januškeviča, G. Stūre, B. Rozentāle, J. Storoženko, L. Vīksna. Ar HIV inficētam mātes intrauterīnas augļa HIV inficēšanās prognozēšanas paņēmiens pirmajos sešos grūtniecības mēnešos: LV 15133 B: patents. Pieteikts: 09.03.2016; publicēts: 20.01.2017. Izgudrojumi, Preču Zīmes un Dizainparaugi. Nr. 1 (2017), 6. lpp.  

International journals

  • I. Azina, J. Eglite, O. Kolesova, A. Kolesovs, J. Storozenko, G. Sture, E. Hagina, B. Rozentale, A. Lejnieks. The relationship between HLA class II alleles and immunological status of patients with HIV-assosiated tuberculosis in Latvia. World Journal of Pharmaceutical and Medical Research. Vol. 3, Issue 2 (2017, March), p. 27–32.
  • Kolesova O., Kolesovs A., Vetra J. Age-Related Trends of Lesser Pelvic Architecture in Females and Males: a CT pelvimetry study. Anatomy and Cell Biology, Vol. 50, No. 4, 2017, p. 34–40.
  • S. Skribāne, L. Bajāre, O. Koļesova. The anatomical characteristics of n. trigeminus blockade sites. Proceeding of the 59th International Scientific Conference of Daugavpils University (Daugavpils 2017, 6–7 april) p. 515–519.

Abstracts

  • Z. Davidsone, E. Eglite, A. Kolesovs, R. Santere, V. Stanevica. HLA II class alleles in juvenile idiopathic arthritis patients with and without chronic arthritis signs in temporomandibular joints evaluated with contrast enhanced MRI. Pediatric Reumatology. Vol. 15, Suppl. 2 (2017), p. 35.
  • I. Ažiņa, J. Eglīte, E. Hagina, J. Storoženko, B. Rozentāle, A. Lejnieks. HLA II klases gēnu polimorfisma saistība ar imunoloģiskā statusa rādītājiem pacientiem ar HIV asociēto tuberkulozi Latvijā. RSU zinātniskā konference, 2017, tēzes, 5. lpp.
  • I. Ažiņa, J. Eglīte, G. Stūre, J. Storoženko, O. Koļesova, T. Kolupajeva, L. Guseva, B. Rozentāle. Homozigotāte HLA-DQB1 lokusā un tās negatīvā ietekme uz HIV-1 un tuberkulozes koinfekcijas gaitu. RSU zinātniskā konference, 2017, tēzes, 4. lpp.
  • O. Koļesova, J. Eglīte, I. Ažiņa, B. Rozentāle. IFN-γ produkcijas saistība ar ORAI1 gēna ekspresijas līmeni pacientiem ar HIV asociēto tuberkulozi (pilotpētījums). RSU zinātniskā konference, 2017, tēzes, 7. lpp.
  • S. Laivacuma, J. Eglīte, L. Vīksna. Risk fectors of echinococcosis in Latvia. 7th Conference of the Scandinavian-Baltic Society for parasitology (Riga, Latvia, June 8–9, 2017): Abstracts, p.27.
  • O. Kolesova, J. Eglite, I. Azina, B. Rozentale. Negative impact of homozygosity in HLA-DQB1 locus on HIV-associated tuberculosis. 47th Annual Meeting of the German Society for Immunology, Erlangena, 2017, tēzes, 90. lpp.
  • Bridina L., Gintere S., Mikule L., Eglīte J., Krumina A. Relationship of Blood Planting Gram-positive and Gram-negative Bacteria with Procalcitonin and C-reactive protein in Serum of Sepsis Patients. RSU zinātniskā konference, 2017, tēzes, 23. lpp.
  • Eglite J., Jasinskis V., Hagina E., Kolesova O., Kasjko D., Locs J., Vectaudza J., Rubenis K. A Systematic review on the use of immune system involvement in bone reconstitution using hydroxyapatite (HAp). European Advanced Materials Congress (EAMC) (Stockholm, Sweden, Aug. 22–24, 2017). www.vbripress.com/eamc, DOI:10.5185/eamc.2017
  • Eglite J., Jasinskis V., Hagina E., Kolesova O., Kasjko D. Theretical Foundation for the Use of Hydroxyapatite (HAp) for Bone Repairs. RSU zinātniskā konference, 2017, tēzes, 44. lpp.
  • S. Skribāne, L. Bajāre, O. Koļesova. The anatomical characteristics of n.trigeminus blockade sites. Abstracts  of the 59th International Scientific Conference of Daugavpils University(Daugavpils 2017, 6–7 april) p. 98–99.
2016
  • Z. Dāvidsone, J. Eglīte, A. Lazareva, S.Dzelzīte, R. Šantere, D. Bērziņa, V. Staņēviča HLA II class alleles in juvenile idiopathic arthritis patients with and without temporomandibular joint arthritis. Pediatr Rheumatol Online J. 2016 Apr 19;14(1):24. doi: 10.1186/s12969-016-0086-4.
  • J. Eglite, .I.Golushko, E. Urtans, I. Januskevica and B. Rozentale. Association of Tumor Necrosis Factor-α (TNFα) Gene Polymorphisms with HLA Class II Alleles in HIV/AIDS Patients British Journal of Medicine & Medical Research 13(12): 1-10, 2016.,NLM ID 101570965.
  • I. Januškevica, B. Rozentāle, E.Hagina, J. Eglīte, T. Kolupajeva, J. Storozenko, L. Guseva, and Aivars Lejnieks. Role of Interferon-Gamma (IFN-y) in immune response regulation in HIV-1 and HIV-1 + mycobacterium tuberculosis (TB) infected patients. Proceeding of Latvian Academy of Sciences. Section B, Vol. 70 (2016), pp. 211-214.
  • I.Januskeviča, A.Sangirejeva, J.Eglīte, E.Hagina, V.Jasinskis, J.Storozenko, A.Lejnieks and B.Rozentale. Trends in Tuberculosis/Human Immunodeficiency Virus Comorbidity, Latvia, 2012-2014. Journal of Scientific Research& Reports 9(5):1-7,2016;DOI: 10.9734/JSRR/2016/22247.
  • L.Kovalchuka, S.Cvetkova, J.Trofimova, J. Eglite, S.Gintere, I.Lucenko, B.Oczko-Grzesik, L. Vīksna, and A. Krumina. Immunogenetic Markers Definition in Latvian Patients with Lyme Borreliosis and Lyme Neuroborreliosis. International Journal of Environmental Research and Public Health 2016, 13, 1194; doi:10.3390/ijerph13121194.
  • L.Kovaļčuka, J.Eglite, M.Zālīte, I.Lucenko, L.Vīksna and A.Krūmiņa. Immunogenetic manifestations of lyme borreliosis . Proceeding of Latvian Academy of Sciences. Section B, Vol. 70 (2016), pp. 215-219.
2015
  • I. Januškeviča, A.Sangirejeva, J.Eglīte, E.Hagina, V.Jasinskis, J.Storozenko, A.Lejnieks and B.Rozentale. Trends in Tuberculosis/Human Immunodeficiency Virus Comorbidity, Latvia, 2012.-2014. Journal of Scientific Research& Reports 9(5):1-7, 2016. Article no JSRR.22247 ISSN:2320-0227.
2014
  • E. Eglite, E. Hagina, J. Pavare, I. Grope, L. Eihvalde, A. Sochnevs and D. Gardovska. Genetic Polymorphisms HLA Class II in SIRS and Sepsis in Children. British Journal of Medicine and Medical Research. 4(1):149-160. 2014.
  • V. Jasinskis, D. Kasjko , E. Eglite, G.Sture , L.Viksna, B. Rozentale, A. Sochnevs, Comparison of Antiretroviral Therapy (ART) Efficiency and Different HLA Class II Haplotypes, British Journal of Medicine & Medical Research 4(7): 1473-1482. March,2014.g.
  • D.  Kasjko., V.  Jasinskis., E. Dobele., L. Kovaļčuka., J. Eglīte., A. Sočņevs., G. Stūre., L. Vīksna. DRB1*01:01 gēna mutācijas izpēte 2.eksonā HIV/AIDs slimniekiem. RSU Zinātniskie raksti 2013, 2013. gada medicīnas nozares pētnieciskā darba publikācija, 2014 – 337.–344.
  • D. Kasjko, V. Jasinskis, E. Eglite, L. Kovalchuka,Elina Dobele, G. Sture, A. Sochnevs, and  L. Viksna. Mutations in HLA DRB1*0101 Exon 2 in a Sub-population of Latvia. British Journal of Medicine & Medical Research 4(4): 981-989. 2014
  • D. Kasjko, V. Jasinskis , E. Eglite, J.Golushko, G. Sture, A. Kalimulin, A. Sochnevs, and  L. Viksna. Research of HLA II class DRB1, DQA1, DQB1 genetic markers in patients with HIV infection and AIDS. British Journal of Medicine & Medical Research 4(27): 4482-4500, 2014.
  • L. Kovalchuka, J. Eglite, M. Zalite, I.Lucenko, I. Logina, G. Karelis, L. Viksna, A. Krumiņa. The frequency of HLA-DR alleles in patients with Tick-borne disease from Latvia. Res J Infect Dis 2014. ISSN:2052-5958. Volume 2, Article 4, doi: 10.7243/2052-5958-2-4.
  • A. Krumina, G. Vasiljeva, A. Ivanovs, S. Gintere,  L. Kovalchuka, S. Rasa,   S. Chapenko, M. Murovska, L.Viksna and I. Logina. Assessment of  Value of Fatigue Severity and Symptoms in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Fibromyalgia. British Journal of Medicine & Medical Research 4(36): 5866-5877, 2014.     ISSN:2231-0614. Pub. date: 26.august 2014.
  • L.Viksna, A. Jeruma, J.Eglite, A.Sočņevs, and V.Sondore. Biochemical and Immunogenetic Diagnostic Markers Less Commonly Used for Predicting the Efficacy of Chronic Hepatitic C Etiotropic.Therapy.Virology&Mycology,ISSN:2161-0517 VMID, an open access journal. Pub. date: May 08,2014.

 

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