Complex multifunctional analytical equipment for biopharmaceutical evaluation of hard-to develop oral medicines

This innovative system will be used in simultaneous investigation of drug (or active pharmaceutical ingredients, APIs) permeability across ex vivo and artificial membranes with compendial release and/or dissolution. Artificial digestion, including lipolysis and proteolysis will be optionally added to this system, allowing simultaneous research of the impact of artificial digestion on permeability in tandem with compendial drug release/dissolution. System will be applied in biopharmaceutical research of oral dosage forms and will impact multiple current pharmaceutical drug development problems, namely:

• Improve the bioavailability of oral formulations
• Decrease the financial investments in clinical studies
• Increase the success rate and reduce the risks of clinical studies
• Improve the therapeutical outcomes of drug treatment
• Decrease the dose of the drug required to achieve therapeutical effect
• Decrease the amount of non-absorbed drug and its impact on the environment

The project shall be implemented in cooperation with the partner SIA Saint-Tech.

Results

• On 3 June 2025, agreement No. 1.1.1.3/1/24/A/117 with CFCA about the implementation of the project concluded.