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About Study Course

Credit points / ECTS:4 / 6
Course supervisor: Jeļena Krasiļņikova
Study type:Full time
Course level:Bachelor
Target audience:Medicine
Language:English
Branch of science:Chemistry; Biochemistry

Objective

To provide theoretical and practical knowledge of metabolism in whole of human organism on molecular level; joining of regulation and integration of biochemical pathways as base of physiological health and homeostasis; quantitative and qualitative detection of important biochemical markers.
To ensure face to face studies, as well as distance learning by use of such platforms as Zoom, e-studies, google docs, Panopto etc.

Prerequisites

Physics, chemistry, biology, anatomy.

Learning outcomes

Knowledge

In the end of the course students will be able to name factors influencing enzyme’s activity, to group digestive enzymes according to their action mechanism and name main digestive enzymes of all nutrient classes. They will be also able to recognize and name main metabolites of carbohydrate metabolism and characterize regulation and enzymes of glycolysis, oxidative decarboxylation and Krebs cycle, to recognize and name main metabolites of lipid metabolism and characterize regulation and enzymes of beta oxidation and fatty acid biosynthesis, to recognize and name main metabolites of amino acid metabolism and characterize regulation and enzymes of ammonium detoxification, characterize metabolic pathways in human metabolism that connects carbohydrates, lipids and amino acids and allows these groups to transform in to each other, name hormones that regulate these transformations. Students will learn methods required for basic biochemistry analysis performed in medicine.

Skills

In the end of the course students will be able to:
• explain based on enzyme action mechanism how various factors influence enzymes activity;
• explain how molecules are sequentially digested during digestion process, identify end products of digestion process;
• explain step by step with appropriate metabolic pathways how carbohydrates are degraded for energy of how they are stored;
• explain step by step with appropriate metabolic pathways how lipids are degraded for energy of how they are stored;
• explain step by step with appropriate metabolic pathways how amino acids are degraded for energy, the fate of “carbon skeletons” and amino group;
• explain step by step with appropriate metabolic pathways how lipids and carbohydrates are inter-converted, in which direction they are regulated in various metabolic situations;
• explain principles of biochemical analysis that are commonly used to analyze blood and urine to determine overall functional state of human organism.

Competence

In the end of the course students will be able to:
• assess how possible perturbations in homeostasis of human body would influence activity of enzymes and predict possible consequences within total metabolism;
• assess how low activity of certain digestion enzyme would influence digestion process and overall spectra of absorbed nutrients;
• assess how disturbance of certain metabolic pathway from basic carbohydrate, lipid of amino acid metabolism could perturb the metabolic network and predict possible consequences on human metabolism;
• conduct laboratory experiment, use corresponding equipment and evaluate results in future practical or scientific work;
• integrate knowledge of metabolic pathways with information from other courses thus giving a whole and multifaceted view on human organism.

Study course planning

Planning period:Year 2020, Autumn semester
Study programmeStudy semesterProgram levelStudy course categoryLecturersSchedule
Medicine2Master’sRequiredAgnese Kokina, Jeļena Raudeniece, Ilze Justamente, Dace Reihmane, Jeļena Krasiļņikova, Kalvis Brangulis, Evita Vaļēviča, Kristiāna Kovtuna