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Supervisor
Juta Kroiča

Study Course Description

Course Description Statuss:Approved
Course Description Version:3.00
Study Course Accepted:16.07.2018
Study Course Information
Course Code:BUMK_015LQF level:Level 6
Credit Points:8.00ECTS:12.00
Branch of Science:Medicine; Microbiology and VirologyTarget Audience:Medicine
Study Course Supervisor
Course Supervisor:Juta Kroiča
Study Course Implementer
Structural Unit:Department of Biology and Microbiology
The Head of Structural Unit:Juta Kroiča
Contacts:Rīga, Dzirciema iela 16, bmkatrsu[pnkts]lv, bmkatrsu[pnkts]lv, +371 67061584
Study Course Planning
Full-Time - 1. Semester No.
Lectures (number)15Lecture Length (academic hours)2Total Contact Hours of Lectures30
Classes (number)16Class Length (academic hours)3Total Contact Hours of Classes48
Total Contact Hours78
Lectures (number)15Lecture Length (academic hours)2Total Contact Hours of Lectures30
Classes (number)17Class Length (academic hours)3Total Contact Hours of Classes51
Total Contact Hours81
Study course description
Preliminary Knowledge:
Molecular Biology, Anatomy, Histology, Genetics, Physiology and Biochemistry.
Objective:
To provide knowledge about structure and properties of bacteria, viruses, fungi and parasites and their role in infectious disease. To provide knowledge about innate and adaptive immune response. Bacteriological, virological and serological diagnostic methods. Diagnostics of fungal and parasitic infections. To provide knowledge about antibiotics, their mechanisms of action and mechanisms of antibacterial resistance.
Topic Layout (Full-Time)
No.TopicType of ImplementationNumberVenue
1Brief history of microbiology. Taxonomy of microorganisms. The structure of bacterial cellLectures1.00auditorium
2Antibiotics. The mechanisms of antibacterial resistance.Lectures1.00auditorium
3Bacterial metabolism. Microbial growth.Lectures1.00auditorium
4The atypical bacteria, fungi, viruses. Bacterial pathogenicityLectures1.00auditorium
5Normal human microbiota and microbiota of an environment. Control of microbial growth. Infection.Classes1.00laboratory
6Immunity. Innate immunity. Complement system.Classes1.00laboratory
7Antigens. MHC-I and II cl. Ag. Antibodies – structure, properties, functions. Immunoglobulin classesClasses1.00clinical base
8T Lymphocytes, hystiogenesis, receptors, functions. NK cellsClasses1.00laboratory
9B ly,Macrophages, APC. Primary and secondary humoral immune response.Classes1.00laboratory
10Cellular immune response. Antiviral immune response.Classes2.00laboratory
11Hypersensitivity. Immune pathology.Lectures1.00auditorium
12Anaerobic infections. Corynebacterium diphtheria.Lectures1.00auditorium
13Shigella and Yersinia. Campylobacteria. Helicobacter pylori. Vibrio choleraeLectures1.00auditorium
14Enterobacteriaceae. E.coli. Salmonella.Lectures1.00auditorium
15Bordetella, Pseudomonas, Legionella, A.baumanii, i/c Bacteria.Lectures1.00auditorium
16Safety in microbiology laboratory. Microscopy. Microbiological smears. Simple methods of staining.Lectures2.00auditorium
17Complex methods of staining. The morphology of bacterial cell - endospores, flagella, inclusion bodies.Lectures1.00auditorium
18Cultivation of bacteria. Media. The atypical bacteria, fungi, viruses.Classes1.00laboratory
19Pure cultures. Cultivation of anaerobic microorganisms. Identification of pure cultures. Cultural, morphological, biochemical properties of bacteria. Sampling of normal microbiota of human body.Classes1.00laboratory
20Examination of microbial flora of air and water. Normal microbial flora of human body.Classes1.00laboratory
21Microbial antagonism. Examination of antibacterial susceptibility. Disinfection methods. Sterilisation methods.Classes1.00laboratory
22Microbiological examination of infectious diseases.Classes1.00laboratory
23Serological reactions. Diagnosticums. Immune sera. Agglutination reactions.Classes1.00laboratory
24Precipitation test. Lytic reactions. Complement fixation test.Classes1.00laboratory
25The use of labeled antibodies and antigens in serological reactions (ELISA, IFA). PCR.Classes2.00laboratory
26Antiviral, antitoxic, antifungal, anticapsular immune response.Lectures1.00laboratory
27Immunization, immunological prevention.Lectures1.00auditorium
28Immune pathology, hypersensitivity.Lectures1.00auditorium
29ColloquiumLectures1.00auditorium
30Final testLectures1.00auditorium
31Hospital acquired infections. Clinical bacteriology.Lectures1.00auditorium
32The causative agents of Tuberculosis and Actinomycosis.Lectures1.00auditorium
33Pathogenic coccus.Lectures1.00auditorium
34Fungal infectionsLectures1.00auditorium
35Herpesviruses. Adenoviruses.Classes1.00laboratory
36Enteroviruses. Hepatitis A, B, C, D, E, TT viruses.Classes1.00laboratory
37Neurotropic viruses. Slow viral infections. Oncogenic viruses.Classes1.00laboratory
38Respiratory viruses.Classes1.00laboratory
39Microbiological diagnosis of E.coli, Salmonella spp., Klebsiella spp. and Proteus spp. infections. Detection of E.coli in water.Classes1.00laboratory
40Microbiological diagnosis of the diseases caused by Yersinia, Shigella, Campylobacter, Helicobacter and Vibrio cholerae.Classes1.00laboratory
41Microbiological diagnosis of diseases caused by Staphylococcus spp. and Streptococcus spp., gonococcus and meningococcus.Classes2.00laboratory
42Microbiological diagnosis of diphtheria, pertussis H.influenzae and infections caused by genus Clostridium.Lectures1.00auditorium
43Microbiological diagnosis of Tuberculosis, Mycobacteria spp., Actinomycosis.Lectures1.00auditorium
44Syphilis, Borreliosis and Leptospirosis. Diagnostic tests of diseases caused by Chlamydia, Mycoplasma.Lectures1.00auditorium
45Clinical bacteriology. Examination of pus, blood, sputum and urine, cerebro-sprinal fluid. Diagnostic tests of diseases caused by Fungi.(Dermatophytes, Candida, Cryptococcus)Lectures1.00auditorium
46Diagnostic tests of diseases caused by respiratory viruses.Lectures1.00auditorium
47Diagnostic tests of the Enteroviruses and diseases caused by Hepatitis Viruses.Classes1.00laboratory
48Diagnostic tests of diseases caused by Neurotropic viruses (Tick born Encephalitis viruses, Rhabdoviridae).Classes1.00laboratory
49Diagnostic tests of HIV, AIDS.Classes2.00laboratory
50HIV, AIDS.Lectures1.00auditorium
51Pathogenic Spirochettae.Lectures1.00auditorium
52Introduction to medical parasitology.Classification of parasites. Helminths– trematodes (Trematoda) and cestodes (Cestoda)Lectures1.00auditorium
53Helminths – nematodes (Nematoda).OvohelminthoscopyLectures1.00auditorium
54Parasitic protists (Protozoa), their classification. Classes Flagellata, Sarcodina, Ciliata/Infusoria and Phylum ApicomplexaClasses1.00laboratory
55Parasitic arthropods (Arthropoda), their significance as vectors. Vector borne diseaseClasses1.00laboratory
56Helminths – trematodes, their characteristics: Fasciola hepatica, Schistosoma spp. Cestodes, their characteristics: Taenia solium, T. saginata, Diphyllobothrium latum, Hymenolepis nana, Echinococcus granulosus, Echinococcus multilocularisClasses1.00laboratory
57Helminths – nematodes, their characteristics: Enterobius vermicularis, Ascaris lumbricoides, Trichuris trichiura, Trichinella spiralis, Toxocara cati, Toxocara canis.Classes2.00auditorium
Assessment
Unaided Work:
Within the framework of the course, students work individually and in groups. The preparation of presentations in accordance with the topics of the course.
Assessment Criteria:
- Regular attendance of practical classes and active participation in them; - Passed semester colloquia. A colloquium includes the assessment of theoretical knowledge and practical skills; - At the end of the course – a written examination consisting essay-type questions and questions regarding practical classes.
Final Examination (Full-Time):Exam (Written)
Final Examination (Part-Time):
Learning Outcomes
Knowledge:After completion of the course the students will be able to describe bacteria, viruses, fungi and parasites, to understand their pathogenicity factors as well as their role in the origin of infectious diseases and in the interrelation with host. They will be infromed about the main methods of diagnostics, unspecific and specific methods of prevention of infectious diseases.
Skills:After completion of the course the students will be able: - to collect, transport and examine patients material, - to identify the pure culture of the causautive agents, evaluate their antibacterial susceptibility; - to use bacteriological , serological and molecular methods.
Competencies:Upon combining of theoretical knowledge and practical skills, the students will be able to understand the significance of viruses, bacteria, fungi and parasites as causative agents of diseases and to relate them to the mechanisms of patghogenecity and interreasction with the host.
Bibliography
No.Reference
1MIKROBIOLOĢIJA
2Medical Microbiology, Murray, Patrick R. Datu bāze:
3ClinicalKey
4Jawetz, Melnick & Adelberg’s Medical Microbiology
5AccessMedicine
6Review of Medical Microbiology and Immunology, Warren Levinson
7AccessMedicine
8Sherris Medical Microbiology, Ryan
9AccessMedicine
10Metodiskās rekomendācijas praktiskajām nodarbībām „Vispārīgā mikrobioloģija”. Rīga, RSU, 2015
11Imunoloģija:
12Review of Medical Microbiology and Immunology, Warren Levinson
13AccessMedicine
14Cellular and Molecular Immunology, Abbas Abul K.
15ClinicalKey
16Metodiskās rekomendācijas praktiskajām nodarbībām „Infekcija un imunitāte”. Rīga, RSU, 2017.
1Prof. A.Lejnieka red. Klīniskā medicīna. 3. grāmata.Medicīnas apgāds. 2012.
2A. Žileviča, Medicīna mikrobioloģija I Vispārīgā mikrobioloģija un infekcijas imunoloģija, LU Akadēmiskais apgāds, 2014.
1http://estudijas. rsu.lv.
2http://www.medscape.com
3http://www.pubmed.com