Development of new anti-cancer medicines for treatment of rare tumours in triterpenoid group of lupane series

Project/agreement No.

6.2.-25/2016/0175

Project funding

150 000.00 EUR, including 75 000.00 EUR RSU funding and 75 000.00 EUR RTU funding

Project manager

asoc.prof. Dr.pharm. Reinis Vilšķērsts, Māris Turks (RTU)

Project realization

15.02.2016. - 28.02.2019.

Aim

Develop new derivatives of pentacyclic triterpenoid of lupane series having an anti-tumour effect against rare tumours

Description

Rīga Stradiņš University and Riga Technical University carry out a scientific cooperation project during the period from February 2016 to February 2019 aimed at establishing inter-university research teams, conducting interdisciplinary and competitive studies

Activities of the project

1. Betulin extraction technology from birch bark
2. Betulonic acid derivatives C-H activation
3. Synthesis of pentacyclic triterpenoid of lupane series – triazole conjugates
4. Synthesis of pentacyclic triterpenoid of lupane series – isoxazole conjugates
5. Substance verification in an isolated mitochondial model
6. Optimisation of the most active structures
7. Verification of the most active substances in cell cultures
8. Verification of the most active substances in models in vivo
9. Preparation of international project applications

Partner RTU: activities 1-4, 6
Partner RSU: activities 5, 7 and 8