Epigenomic regulation of cancer immunity by dietary intervention (DICE)
Aim
Description
Various studies indicate that the Western diet, rich in fats and sugars, can influence our immune system, leading it to a state of constant inflammation known as “trained immunity”. This condition may play a significant role in the development of diseases such as cancer. It has been observed that this type of diet alters certain components of the immune system that are crucial for fighting tumors. These alterations not only hinder the body’s ability to defend itself against cancer but also reduce the effectiveness of therapies.
The aim of the project is to better understand how an anti-inflammatory dietary intervention could reverse this process. We believe that by changing the diet, we can reduce inflammation and strengthen the body’s natural defenses against cancer. To test this idea, we will study the cellular and genetic changes that occur in patients with early-stage breast and colorectal cancer, comparing their profiles before and after surgery to remove the tumor.
We will use advanced techniques to analyze how diet influences gene expression and the organization of DNA within cells. This will allow us to identify new biomarkers and potential targets for developing more effective and personalized cancer treatments. Furthermore, this study aims not only to improve current therapeutic options but also to promote collaboration among researchers and share information to guide future cancer research priorities at the European level.
Ultimately, our goal is to generate knowledge that can be translated into better strategies for cancer prevention and treatment, promoting the development of new therapies that help patients achieve better outcomes and an improved quality of life.
Lead Partner
Health Research Institute of Asturias (Spain)
Project Partners
- Rīga Stradiņš University (Latvia)
- Fondazione IRCCS Istituto Nazionale dei Tumori (Italy)
- Azienda Socio Sanitaria Territoriale (ASST) Rhodense (Italy)
- Hungarian Centre of Excellence for Molecular Medicine (Hungary)
- University of Augsburg (Germany)
