High Hydrostatic Pressure: A Dual-Function Method for Processing and Sterilizing Drug-Loaded Hydrogels

The Scientist Grant High Hydrostatic Pressure: A Dual-Function Method for Processing and Sterilizing Drug-Loaded Hydrogels will focus on the high hydrostatic pressure sterilization HHP method, widely applied in the cosmetics and food industry. HHP benefits from a low-temperature load, applicability to liquid/gel-like and unstable structures. Although the HHP method has been known for more than a century, limited research has been done, and unreliable information exists about the application on drug-loaded hydrogel HG.

The novelty of the topic is proved by the fact that there is not much data in the literature on the use of HHP in HG sterilization. The most recent literature highlights a possibility that the sterilization process can be accompanied by controlled alterations in the HGs swelling characteristics and drug release profile. Literature highlights the need for optimization in the HHP process to enhance the sterility, physical and drug release properties of HGs. Given the complexity of numerous parameters and variables at play, this grant aims to employ an innovative Artificial Intelligence/Machine Learning AI/ML algorithm for precision process optimization.

The aim of the grant is to investigate the impact of changes in HHP parameters on the sterility, physical properties, drug release profile, and structure of hydrogel-based drug delivery systems. Additionally, the grant aims to compare the effectiveness of HHP sterilization with other sterilization methods, such as gamma radiation and steam. Optimization of the HHP process using AI/ML is also a significant objective of the grant.

Scientific Publications

Vircava, A., Skadiņš, I., Smelters, Ģ., Brangule, A. High hydrostatic pressure sterilization: A resource optimization approach. Results in Engineering, Volume 28, December 2025, 107662. https://doi.org/10.1016/j.rineng.2025.107662