Skip to main content

Nanoparticle Transfer Through Endothelial Barrier (NanoTENDO)

Project/agreement No.
1.1.1.5/ERANET/20/02
Project funding
600 854.00 EUR, From which 129 910.00 EUR RSU part.
Project manager
Project realization
01.04.2020. - 30.09.2022.

Aim

Aim of present project is to elucidate the mechanisms of transfer through the endothelial barrier for the most promising carbosilane-based NPs: functionalized gold NPs, dendrimers, dendrons and their complexes with drugs and nucleic-acids-based immunomodulators.

Description

Lead partner of the projekt - University of Lodz

Partners of the project - University of Alcala, Faculty of Sciences, Department of Organic and Inorganic Chemistry, Latvian Biomedical Research and Study Centre 

Project activities:

  1. Study the uptake and efflux of NPs through the endothelial barrier and their cytotoxicity using molecular and cell biology techniques;
  2. Estimate the functional state of the endothelial barrier cells in the presence of NPs and their complexes;
  3. Repeat (1) and (2) under conditions of endothelial barrier stress induced by oxidative stress and acidification (related to brain ischemia) and the presence of amyloid-beta peptides (related to Alzheimer’s disease);
  4. Establish murine models of brain ischemia and AD; and
  5. Approve the therapeutic potential of NP complexes of drugs/nucleic acids tested above in in vivo system.

ERA_ieva.png