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Optical multimodal method for microcirculation assessment in sublingual and gastric mucosal level in patients with septic shock

Project/agreement No.
OSI_PIP_BioPhoT-2025/1-0076
Project funding
200 000.00 EUR, the funding is split between project partners as follows: 111 443 EUR – Institute of Solid State Physics, University of Latvia
Project manager
asoc.prof. Oļegs Sabeļņikovs
Project realization
10.10.2025. - 09.10.2026.

Aim

Develop a technology capable of calculating and assessing microcirculation at the sublingual and gastric mucosa levels from scattered light signals. Conduct real-time measurements in an intensive care setting and refine the prototype based on results obtained in clinical practice.

Description

A new, minimally invasive optical device for real-time assessment of microcirculation at the sublingual and gastric mucosa level.

Sepsis and septic shock are global health problems characterized by high mortality rates and significant healthcare costs. Current sepsis guidelines focus on stabilizing systemic hemodynamics through fluid resuscitation and vasopressor therapy; however, these approaches do not always improve microcirculation.

Microcirculatory disorders cause tissue hypoxia and organ dysfunction, which increase the risk of mortality. At present, microcirculation is usually assessed by capillary refill time (a subjective method) or blood lactate levels (a non-specific method), but both approaches have significant limitations.

The aim of this project is to develop a technology that, using light spectroscopy, can measure tissue oxygenation as well as perfusion and heterogeneity indices. By combining RSU’s clinical expertise with LU CFI’s optical technologies, this innovation will enable continuous microcirculation monitoring at the organ level in septic shock patients during the initial stabilization phase of treatment.

Project Team

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