Paediatric Hemato-Oncology (PEK_068)
About Study Course
Objective
To provide students with in‑depth knowledge of paediatric oncology. In the study process, special emphasis will be placed on the principles of chemotherapy, its mechanisms of action and the most common complications, especially febrile neutropenia as one of the most frequent and potentially life‑threatening complications after chemotherapy, as well as its timely recognition, emergency management and treatment algorithms. The program will also include knowledge of modern therapeutic options in paediatric haemato-oncology, including targeted therapy, immunotherapy, monoclonal antibodies, cell therapy (for example, CAR‑T therapy) and the principles of personalized treatment, highlighting their importance in improving treatment effectiveness and reducing toxicity.Particular attention will also be paid to central nervous system (CNS) tumours as the most common solid tumours in childhood, their clinical signs, neurological symptoms, diagnostic methods and multimodal treatment (surgery, radiotherapy, chemotherapy). Students will also acquire knowledge about late treatment effects, including cardiotoxicity, endocrine disorders, growth and developmental delay, neurocognitive impairments and the risk of secondary tumours, emphasizing the importance of long‑term follow‑up and multidisciplinary care. The aim of the course is to develop clinical reasoning and the ability to critically evaluate strategies for diagnostics, treatment, complication prevention and long‑term follow‑up in paediatric haemato-oncology, ensuring competent and safe care for paediatric patients.
Prerequisites
Basic knowledge of human anatomy, physiology, pathology, immunology, and an introduction to pediatrics.
Learning outcomes
1.The student understands the basic principles of paediatric oncology. The student is familiar with the mechanisms of action of chemotherapy, the principles of developing treatment protocols, risk stratification, and modern therapeutic options (targeted therapy, immunotherapy, cell therapy); understands the most common acute complications, especially febrile neutropenia as an emergency condition, as well as the late effects of oncological treatment and the need for long term follow up.
1.The student is able to analyse clinical cases of paediatric haemato-oncology patients, recognize early signs of malignant diseases, and plan diagnostic investigations.
The student is able to recognize febrile neutropenia, assess its severity, and justify the tactics of emergency therapy.
The student can interpret laboratory and instrumental examinations and assess signs of therapy-induced toxicity.
The student is able to identify possible late effects and plan long-term follow-up.
1.The student is able to independently apply acquired knowledge in paediatric haemato-oncology to the assessment of clinical situations, collaborating with a multidisciplinary team and providing safe, evidence-based care. The student is aware of the importance of timely recognition of acute complications, as well as the role of long-term sequelae prevention and the education of patients and their families, ensuring continuous care from diagnosis to long-term follow-up.
