Elucidation of the mechanism of amorphization and dissolution of bad glass former as a function of drug-polymer interaction and preparation method

The project will study the impact of polymer and solvent properties (solubility parameters, interaction with drugs, molecular weight, rheological properties, and glass transition temperature) on the stability of high drug-loaded ASD solids, thermodynamic and kinetic stabilization. The effect of manufacturing methods (liquid layer coating and electrospinning), process parameter settings on the obtained ASD solids and their physical stability, as well as a comparison of both methods, will be investigated. The impact of ASD composition (polymer type and drug load), manufacturing method, and polymer dissolution rate on the in vitro dissolution profile of the drug under simulated gastric and intestinal conditions, drug and polymer release, as well as critical parameters such as the congruence limit, will be examined. Algorithms will be proposed to tailor the main properties of the manufactured ASD, including the dissolution profile. 

The project is interdisciplinary. It includes the following research areas: pharmacy, materials engineering, polymer chemistry, and physics. The project results will include three publications, three conference theses, and a Latvian patent. 

Expected results

• Original scientific articles published in the Q1 or Q2 high-level journals – 3
• Intellectual property registered in Latvia – 1
• Project proposal submitted in a Latvian call for research and development projects – 1
• Other project results (e. g., datasets, etc.) – 4
• Participation in international scientific conferences – 2
• Participation in national scientific conferences

Most important events of our project

• October 2025: Visiting 5th Conference on Innovation in Drug Delivery (Turin, Italy) wit h poster presentation
• June 2025: Visiting a worldwide-respected professor, Gabriele Sadowski (the Laboratory of Thermodynamics, Faculty of Bio- and Chemical Engineering, Technische Universität Dortmund), who is a key opinion leader in the fundamental science behind of the topic of our project

Scientific publications

• Raciborska L, Buczkowska EM, Kukuls K, Pētersone L, Mohylyuk V. Active tablet coating with the amorphous solid dispersion of ibuprofen-HPMCAS from organic solution. Pharmaceutics. 2025;17(12):1514, 10.3390/pharmaceutics17121514
• Raciborska L, Buczkowska EM, Kukuls K, Mohylyuk V. Poster. Amorphous solid dispersion tablet active coating in a perforated pan coater: proof of concept. 5th Conference on Innovation in Drug Delivery; Turin, Italy: APGI, Lille, France; 2025.10.01-03; 10.13140/RG.2.2.27912.28168

Team

• Zoltan Mark Horvath, ZoltanMark[pnkts]Horvathrsu[pnkts]lv
• Katarīna Gurkina, Katarina[pnkts]Gurkinarsu[pnkts]lv
• Marta Žogota, Marta[pnkts]Zogotarsu[pnkts]lv
• Alīna Jaroslava Frolova, AlinaJaroslava[pnkts]Frolovarsu[pnkts]lv
• Kirils Kukuls, Kirils[pnkts]Kukulsrsu[pnkts]lv
• Valentyn Mohylyuk, Valentyn[pnkts]Mohylyukrsu[pnkts]lv
• Arta Pētersone, Arta[pnkts]Petersonersu[pnkts]lv