Quince biowaste valorization into targeted drug delivery components and innovative health-promoting agents

Project/agreement No.

lzp-2024/1-0255

Project funding

300 000.00 EUR

Project manager

Līga Pētersone

Project realization

01.01.2025. - 31.12.2027.

Aim

The project objective is the creation of new knowledge for obtaining innovative non-toxic and multifunctional drug delivery systems (DDSs), including with health-promoting agents, based on different combinations and modifications of isolated compounds from quince and/or Chaenomeles waste biomass as well as in vitro evaluation of their pharmacokinetics in corresponding media and efficiency on cancer cells.

Description

With the increasing demand in the herbal medicine sector for natural drug delivery components and innovative health-promoting compounds, there is a significant need to diversify the portfolio of natural products. On the other hand, there is a vast amount of agricultural waste rich in bioactive compounds.The Project investigates and analyzes the valuable compounds (such as pectins, oligomers, and low-molecular polyphenols) obtained from quince and/or Chaenomeles pomace, twigs, and leaves.The most significant scientific innovations will be the identification and expansion of the possibilities of applications of quince and/or Chaenomeles waste biomass focused on the field of health promotion. The adaptation of innovative analytical methods for the analysis of quince and/or Chaenomeles compounds will ensure qualitative chemical characterization of the obtained compounds in order to analyze the relationships between individual compounds and biological activities, which can be used to ensure a health-promoting effect. A new strategy with the incorporation of quince polyphenol compounds into pectin matrices will allow modifying drug delivery systems for desired target properties.

Outcomes

Original scientific articles published, submitted or accepted for publication in the Q1 or Q2 quartile publications included in Web of Science Core Collection or SCOPUS databases - 3;
Original scientific articles, published, submitted or accepted for publication in the scientific publications or conference symposia, included in Web of Science Core Collection or SCOPUS databases, for social, human and art sciences included in ERIH PLUS database - 3;
Other peer-reviewed original research articles in other scientific journals and collections of articles (including conference article collections), with an international editorial board - 1;
Project proposal submitted in a Latvian call for research and development projects - 1.