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Pharmacology and Toxicology
Study Course Description
Course Description Statuss:Approved
Course Description Version:5.00
Study Course Accepted:28.08.2023 11:28:21
| Study Course Information | |||||||||
| Course Code: | FLK_044 | LQF level: | Level 7 | ||||||
| Credit Points: | 6.00 | ECTS: | 9.00 | ||||||
| Branch of Science: | Clinical Medicine | Target Audience: | Medicine | ||||||
| Study Course Supervisor | |||||||||
| Course Supervisor: | Mārcis Zeibārts | ||||||||
| Study Course Implementer | |||||||||
| Structural Unit: | Department of Pharmacology | ||||||||
| The Head of Structural Unit: | |||||||||
| Contacts: | Riga, Konsula street 21, 1st floor; Marcis[pnkts]Zeibarts rsu[pnkts]lv; Indra[pnkts]Dumbergarsu[pnkts]lv; +371 67613517 | ||||||||
| Study Course Planning | |||||||||
| Full-Time - Semester No.1 | |||||||||
| Lectures (count) | Lecture Length (academic hours) | Total Contact Hours of Lectures | 0 | ||||||
| Classes (count) | 17 | Class Length (academic hours) | 3 | Total Contact Hours of Classes | 51 | ||||
| Total Contact Hours | 51 | ||||||||
| Full-Time - Semester No.2 | |||||||||
| Lectures (count) | Lecture Length (academic hours) | Total Contact Hours of Lectures | 0 | ||||||
| Classes (count) | 15 | Class Length (academic hours) | 3 | Total Contact Hours of Classes | 45 | ||||
| Total Contact Hours | 45 | ||||||||
| Study course description | |||||||||
| Preliminary Knowledge: | Anatomy, physiology, pathological physiology, biochemistry, microbiology, introduction to clinical medicine and symptoms of diseases. | ||||||||
| Objective: | To extend and provide knowledge of: 1) the basic practical pharmacology and clinical pharmacology in line with learning about pathologies and diseases of the organ systems in the study process, 2) the mechanisms of action of different groups of medicines and their use in treatment of diseases, interactions between medicines and side effects, 3) the impact of medicines used on the mechanisms and pathogenesis of the disease, prescribing the most appropriate medication for the individual patient in a customized dosage scheme and evaluating the risks and benefits of treatment, 4) on how to recognize drug poisoning, recognize their initial characteristics, and provide knowledge on the treatment of drug intoxication, 5) the epidemiology of acute and chronic exogenous intoxication, toxicometric parameters, toxicodynamics symptoms of certain types of poisoning and recommended basic principles of treatment. | ||||||||
| Topic Layout (Full-Time) | |||||||||
| No. | Topic | Type of Implementation | Number | Venue | |||||
| 1 | Introduction. General pharmacology | Classes | 3.00 | auditorium | |||||
| 2 | Autonomic nervous system pharmacology. Pharmacology of cholinergic agents. | Classes | 1.00 | auditorium | |||||
| 3 | Autonomic nervous system pharmacology. Pharmacology of adrenergic agents. | Classes | 1.00 | auditorium | |||||
| 4 | Interim examination N1 | Classes | 1.00 | other | |||||
| 5 | Pharmacology of drugs affecting hemostasis. Pharmacology of diuretics. | Classes | 1.00 | auditorium | |||||
| 6 | Clinical Pharmacology of Cardiovascular Drugs | Classes | 4.00 | auditorium | |||||
| 7 | Interim examination N2. | Classes | 1.00 | other | |||||
| 8 | Pharmacology of drugs affecting the central nervous system. | Classes | 4.00 | auditorium | |||||
| 9 | Interim examination N3 | Classes | 1.00 | other | |||||
| 10 | Hypothalamus and pituitary hormones and pharmacology of their functions affecting drugs | Classes | 1.00 | auditorium | |||||
| 11 | Pharmacology of drugs affecting thyroid function. Pharmacology of agents affecting bone mineralization. | Classes | 1.00 | auditorium | |||||
| 12 | Pharmacology of drugs used in the treatment of diabetes mellitus. | Classes | 1.00 | auditorium | |||||
| 13 | Pharmacology of drugs affecting the reproductive system. Urological Agents. Drugs used in obstetrics. | Classes | 1.00 | auditorium | |||||
| 14 | Interim examination N4 | Classes | 1.00 | other | |||||
| 15 | Pharmacology of steroids and non-steroidal anti-inflammatory drugs. Drugs affecting the metabolism of uric acid. | Classes | 1.00 | auditorium | |||||
| 16 | Pharmacology of drugs affecting the immune system. Monoclonal antibodies. | Classes | 1.00 | auditorium | |||||
| 17 | Pharmacology of medicines affecting the respiratory system. | Classes | 1.00 | auditorium | |||||
| 18 | Pharmacology of Drugs That Affect the Gastrointestinal tract | Classes | 1.00 | auditorium | |||||
| 19 | Pharmacology of drugs used in dermatology and ophthalmology. | Classes | 1.00 | auditorium | |||||
| 20 | Interim examination N5 | Classes | 1.00 | other | |||||
| 21 | Pharmacology of anti-infectives. | Classes | 2.00 | auditorium | |||||
| 22 | Pharmacology of chemotherapeutic agents. Agents affecting hematopoiesis. | Classes | 1.00 | auditorium | |||||
| 23 | Interim examination N6 | Classes | 1.00 | other | |||||
| Assessment | |||||||||
| Unaided Work: | Mastering of general and clinical pharmacology and toxicology, as well as selection and analysis of information on medicines, their use in the treatment process. In order to evaluate the quality of the study course as a whole, the student must fill out the study course evaluation questionnaire on the Student Portal. | ||||||||
| Assessment Criteria: | Each lesson includes an oral or written examination of knowledge (including computerized) on the subject of the current lesson. The final evaluation of the study course consists of a cumulative assessment of six colloquia and an examination assessment in proportions 50:50. The calculation of the final evaluation also takes into account the factor of the colloquia and/or re-examination (the mark to be obtained is the average score from all times). | ||||||||
| Final Examination (Full-Time): | Exam | ||||||||
| Final Examination (Part-Time): | |||||||||
| Learning Outcomes | |||||||||
| Knowledge: | After successful fulfilment of the requirements of the study course, students will have acquired knowledge that will allow them to: describe a therapeutic formula; demonstrate basic theoretical knowledge and competence in general and special pharmacology; describe preparations of pharmacological groups, formulate their mechanisms of action, indications and contraindications, as well as side effects; describe pharmacotherapeutic groups. Students will have basic knowledge of poisoning and overdose of drugs, the toxicometric parameters of agents in the body, the specific toxic action, manifestations, diagnosis, treatment options; knowledge of epidemiology of acute and chronic exogenous intoxication, toxicokinetics, toxicodinamics, symptomatic symptoms of certain types of poisoning, recommended treatment principles and antidotes. | ||||||||
| Skills: | As a result of mastering the course, students will be able to explain the mode of action of specific medicines, anticipate side effects, as well as explain the effect of medicines used in the clinic on the mechanisms and pathogenesis of diseases, select the most suitable medicine in a specific situation and evaluate risks and benefits of treatment. As a result of mastering the toxicology course students will be able to identify the respective toxic agent, to determine the toxicometric parameters of medicines in the body and on the basis of which to predict the course and severity of overdose of the medicinal product, identify acute and chronic diseases caused by them, define conditions for safe use and how to avoid poisoning. Recognize paraclinical and clinical signs of poisoning, from symptoms over time to major clinical syndrome. | ||||||||
| Competencies: | As a result of mastering the study course students will be able to select the most suitable medicines according to the situation, to prescribe relevant pharmacotherapy, to justify their choice in prescribing the specific medicine; based on evidence-based medical data, to evaluate the link of drug treatment with age, gender and comorbidities, choice of medicines and to evaluate the risk-benefit ratio; to independently obtain, select and analyse information on medicines, their use in the therapeutic process. Will be able to use the obtained competence on acute exogenic intoxication risk factors, epidemiology, on the scope of immediate medical aid to an acute toxicological patient. Will be able to show in practice a scientific approach to resolution of topical issues, and to find the necessary information in specific literature. | ||||||||
| Bibliography | |||||||||
| No. | Reference | ||||||||
| Required Reading | |||||||||
| 1 | Brunton, Laurence L., Hilal-Dandan, Knollmann, R., Björn, C. Goodman & Gilman's: The Pharmacological Basis of Therapeutics. 14th Edition. 2022 | ||||||||
| 2 | Katzung, Bertram G. Basic & Clinical Pharmacology. 15th Edition. 2020 | ||||||||
| 3 | Praktiskā farmakoloģija. 4. izd. | ||||||||
| 4 | RSU E-studiju vide. Lekcijas | ||||||||
| 5 | Haschek and Rousseaux's Handbook of Toxicologic Pathology. 4th Edition. 2022, Vol.1. | ||||||||
| 6 | Olson, Kent R., Anderson, Ilene B., et al. Poisoning & Drug Overdose. 8th Edition. 2022 | ||||||||
| 7 | Ārvalstu studentiem/For international students: | ||||||||
| 8 | Brunton, Laurence L., Hilal-Dandan, Knollmann, R., Björn, C. Goodman & Gilman's: The Pharmacological Basis of Therapeutics. 14th Edition. 2022 | ||||||||
| 9 | Haschek and Rousseaux's Handbook of Toxicologic Pathology. 4th Edition. 2022. Vol.1. | ||||||||
| 10 | Olson, Kent R., Anderson, Ilene B., et al. Poisoning & Drug Overdose. 8th Edition. 2022 | ||||||||
| Additional Reading | |||||||||
| 1 | Stringer, Janet L. Basic Concepts in Pharmacology: What You Need to Know for Each Drug Class. 6th Edition. 2022 | ||||||||
| 2 | Brown, Morris J., et al. 2019. Clinical Pharmacology. 12th Edition. | ||||||||
| 3 | Waller, Derek G., et al. 2022. Medical Pharmacology and Therapeutics. 6th Edition. | ||||||||
| 4 | Raffa, Robert B. 2014. Netter's Illustrated Pharmacology. 2nd Edition. | ||||||||
| 5 | Katzung & Trevor's Pharmacology: Examination & Board Review. 12th Edition. | ||||||||
| 6 | Лекарственная токсикология. 2014. | ||||||||
| Other Information Sources | |||||||||
| 1 | Dynamed | ||||||||
| 2 | https://druginfo.nlm.nih.gov/drugportal/drugportal.jsp | ||||||||
| 3 | http://www.vmnvd.gov.lv/lv/420-kliniskas-vadlinijas/klinisk… | ||||||||
| 4 | Pharmacology > Pharmacology Lecture Videos | ||||||||
| 5 | Pharmacology > Cardiology | ||||||||
| 6 | Pharmacology > Neurology | ||||||||
| 7 | Interactive Clinical Pharmacology | ||||||||
| 8 | https://www.drugbank.ca/ | ||||||||
| 9 | https://pubchem.ncbi.nlm.nih.gov/ | ||||||||
| 10 | https://medlineplus.gov/ | ||||||||
| 11 | American Academy of Clinical Toxicology | ||||||||
| 12 | American College of Medical Toxicology | ||||||||
