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Work experience

2013 - Present

Acting Associate Professor​​

Faculty of Pharmacy, Department of Pharmaceutical Chemistry​

2012 - Present

Asociated professor

RigaTechnical University Department of Chemistry

2011 - Present

Principal Scientist, ibidem

1994 - Present

Research Associate (not full day), Laboratory of Membrane active compounds at Latvian Institute of Organic Synthesis​​

2005 - 2012

Docent, ibidem​​

2010 - 2011

Riga Stradins University, Department of Human Physiology and Biochemistry, lecturer​​

2004 - 2005

Lecturer, ibidem​​

1995 - 2004

Research Associate, ibidem​​

1991 - 1994

Research Assistant, ibidem​​

Education and training

2005

Dr.chem. Riga Technical university, Faculty Material Science and Applied Chemistry; Thesis „Cycloaddition and side-chain reactions of fullerene C60";

2001

Traineship at Ber Sheva University (Israel)

1998

the Nordic scholarship of Danish Ministry of Higher education in Department of Chemistry (Odense University, Denmark) and CISMI (Co­penhagen University, Denmark)

1994

Traineship at at Department of Bichemistry and Molecular Biology (Bern University, Switzerland)

1986 - 1991

University of Latvia, Faculty of Chemistry; speciality – chemistry (chemistry of natural products)

Achievements

Supervised study course

Organic Chemistry

Lectured study course

Organic Chemistry

Projects

The participant research projects and programs:


2014-2017

Valsts pētījumu programma "Biomedicīna sabiedrības veselībai (BIOMEDICINE)"​


01/09/2013 – 21/08/2015

Project 2013/0002/1DP/1.1.1.2.0/13/APIA/VIAA/005 „Cilvēkresursu piesaiste jaunu heterociklisku pretvēža vielu un diagnostikas līdzekļu iegūšanai un to praktiskā pielietojuma pētījumiem"


01/04/2012 – 15/05/2015

​Project EuroNanoMed „Chemo-hyperthermal Delivery – Combined chemo-hyperthermal control of hepatic tumors based on microwawe-activated subendothelialtargeted nano-assemblies" (CheTherDel)

Awards

L`OREAL – UNESCO Latvia award „For Women in Science" with assistance of Latvian Academy of Science (2006)

Publications

Research articles​​

Evaluation of antiradical activity and reducing capacity of synthesised bispyridinium dibromides obtained by quaternisation of 4-pyrildyl-1,4-dihydropyridines with propargyl bromide / M.Plotniece, M.Rucins, M.Gosteva ...[et al.] // Australian Journal of Chemistry. - Vol.68, No.1 (2015), p.86-92. - Starptautiski citējamā izdevumā.

Studies of the physicochemical and structural properties of self-assembling cationic pyridine derivatives as gene delivery agents / M.Plotniece, O.Petrichenko, M.Rucins ...[et al.] // Chemistry and Physics of Lipids. - Vol.191 (2015, Oct.), p.25-37. - Starptautiski citējamā izdevumā.

Synthesis and evaluation of reducing capacity and calcium channel blocking activity of novel 3,5-dipropargylcarbonyl-substituted 1,4-dihydropyridines / M.Plotniece, M.Rucins, M.Gosteva ...[et al.] // Chemistry of Heterocyclic Compounds. - Vol.50, No.10 (2015, Jan.), p.1432-1443. - Starptautiski citējamā izdevumā.

Synthesis and studies of calcium channel blocking and antioxidant activities of novel 4-pyridinium and/or N-propargyl substituted 1,4-dihydropyridine derivatives / M.Rucins, D.Kaldre, M.Plotniece ...[et al.] // Comptes Rendus Chimie. - Vol.17, No.1 (2014, Jan.), p.69-80. - Starptautiski citējamā izdevumā.

Gene delivery agents possessing antiradical activity : self-assembling cationic amphiphilic 1,4-dihydropyridine derivatives / M.Plotniece, K.Pajuste, M.Rucins ...[et al.] // New Journal of Chemistry. - Vol.37, No.10 (2013, Oct.), p.3062-3075. - Starptautiski citējamā izdevumā.

Studies of preparation and stability of liposomes formed by 1,1'-[(3,5-didodeciloxycarbonyl-4-phenyl-1,4-dihydropyridine-2,6-diil)-dimethylen] bispyridinium dibromide / M.Plotniece, M.Rucins, K.Pajuste ...[et al.] // Advanced materials researches, engineering and manufacturing technologies in industry / ed. by H.Tan. - Trans Tech Publications, 2013. - Chapter 1, p.157-162. - Starptautiski citējamā izdevumā.

Abstracts​​

Characterisation of physical-chemical and self-assembling properties of pyridinium moieties containing 1,4-dihydropyridine and pyridine derivatives as NADH/NAD analogues for development of gene delivery systems / M.Plotniece, D.Bandere, K.Pajuste ...[et al.] // 2016.gada Zinātniskās konferences tēzes (Rīga, 2016.g. 17.-18.martā) / Rīgas Stradiņa universitāte. - Rīga, 2016. - 126.lpp.

Pyridinium derivatives for development of theranosticnanosystems / Kl.Pajuste, O.Petricenko, M.Plotniece ...[et al.] // 2nd International Conference "Current trends of cancer theranostics" (CTCT-2016) (Druskininkai, Lithuania, June 19-23, 2016) : Abstracts Book. - Riga, 2016. - P.72.

Studies of transesterification reactions of ethyl acetoacetate with alcohols catalysed by lipases / B.Gruebler, Kl.Pajuste, M.Plotniece ...[et al.] // 9th Biennial International Conference on Organic Synthesis (BOS 2016) (Riga, Latvia, July 3-6, 2016) : Abstracts Book. - Riga, 2016. - P.69.

Self-assembling cationic pyridine derivatives - NAD/NADH analogues as gene delivery systems : bilogical and physicochemical properties / K.Pajuste, M.Rucins, M.Plotniece ...[et al.] // Drug Discovery Conference (Riga, Latvia, Aug.27-29, 2015) : Abstract Book. - Riga, 2015. - P.131.

Structure-activity relationships of delivery agents in a series of self-assembling pyridines as NAD/NADH analoques / O.Petricenko, A.Vezane, M.Plotniece...[et al.] // 29th Conference of the European Colloid and Interface Society (ECIS 2015) (Bordeaux, France, Sept.6-11, 2015) : Abstracts Book. - Bordeaux, 2015. - P.28.

Studies of structure-activity relationships of nanoparticles as novel gene delivery agents [Elektroniskais resurss] : [abstract] / K.Pajuste, A.Vezane, M.Plotniece ...[et al.] // 7th International Conference on Nanotechnologies and Advanced Materials (EuroNanoForum 2015) (Riga, Latvia, June 10-12, 2015) [Elektroniskais resurss]. - Riga, 2015. - 1 p. - Resurss aprakstīts 2016.g. 29.janv. - Pieejas veids: Tīmeklis WWW.URL: http://euronanoforum2015.eu/wp-content/uploads/2015/03/Abst…

Studies of substituent influence on physical-chemical properties and biological activity in a series of cationic 1,4-dihydropyridines as gene delivery agents / Kl.Pajuste, K.Pajuste, M.Plotniece ...[et al.] // Abstract Book of the European Nanomedicine Meeting (ENM 2015) (Grenoble, France, Dec.7-9, 2015). - Grenoble, 2015. - P.24.

Synthesis, studies of properties and structure-activity relationships of new delivery systems based on the self-assembling polyfunctional pyridinium derivatives / A.Sobolev, V.Ose, M.Plotniece ...[et al.] // 4th International Conference on Multifunctional, Hybrid and Nanomaterials (Sitges, Spain, March 9-13, 2015) : Abstract Book. - Sitges, 2015. - P3.033.

Neibolte, I. Synthesis and spectroscopic properties of substituted 2-cinnamoyl-1,3-indandione O-methyl ethers / I.Neibolte, M.Plotniece, V.Kampars ...[et al.] // 55th International Scientific Conference of Riga Technical University (Riga, Latvia, Oct.14-17, 2014) : Abstract Book. - Riga, 2014. - P.100.

Stirilpiridīnija grupu saturošu 1,4-dihidropiridīna atvasinājumu sintēze un īpašību izpēte / M.Plotniece, D.Bandere, K.Pajuste ...[u.c.] // 2014.gada Zinātniskās konferences tēzes (Rīga, 2014.g. 10.-11.aprīlī) / Rīgas Stradiņa universitāte. - Rīga, 2014. - 81.lpp.

Structure-activity relationships for delivery agents on the scaffold of self-assembling cationic 1,4-dihydropyridines / M.Plotniece, A.Plotniece, M.Gosteva ...[et al.] // 28th Conference of the European Colloid and Interface Society (ECIS 2014) (Limassol, Cyprus, Sept.7-12, 2014) : Abstracts Book. - Limassol, 2014. - P.13.

Synthesis and studies of novel bispyridinium-1,4-dihydropyridine dibromides / M.Plotniece, M.Rucins, M.Gosteva ...[et al.] // 8th Biennial International Conference on Organic Synthesis (BOS 2014) (Vilnius, Lithuania, July 6-9, 2014) : Abstracts Book. - Vilnius, 2014. - P.128.

Synthesis of novel bispyridinium-1,4-dihydropyridine Dibromides and evaluation of their antiradical activity and reducing capacity : [abstract] / M.Plotniece, M.Rucins, M.Gosteva ...[et al.] // Assets of Chemistry in Drug Discovery : 21st Young Research Fellow Meeting (XXIemes Journées Jeunes Chercheurs SCT) (Montpellier, France March 24-25, 2014). - Montpellier, 2014. - P.58.

Synthesis of novel methylene bridged polycyclic diazocines and their rearrangement into spirocyclic compounds / M.Plotniece, B.Cekavicus, A.Plotniece ...[et al.] // Abstracts of Riga Technical University 55th International Scientific Conference. Subsection: Environmental and Climate Technologies (Riga, Latvia, Oct.14-17, 2014) / Riga Technical University. Institute of Energy Systems and Environment. - Riga, 2014. - P.29.

Synthesis of self-assembling cationic 1,4-dihydropyridines as delivery agents for studies of structure-activity relationships / M.Plotniece, D.Bandere, A.Plotniece ...[et al.] // 8th Biennial International Conference on Organic Synthesis (BOS 2014) (Vilnius, Lithuania, July 6-9, 2014) : Abstracts Book. - Vilnius, 2014. - P.118.

The influence of substituent on physical-chemical properties of 1,4-dihydropyridine as delivery agents / M.Plotniece, M.Gosteva, V.Ose ...[et al.] // Abstracts of Riga Technical University 55th International Scientific Conference. Subsection: Environmental and Climate Technologies (Riga, Latvia, Oct.14-17, 2014) / Riga Technical University. Institute of Energy Systems and Environment. - Riga, 2014. - P.28.

Neibolte, Ilze. Synthesis and photoluminescence of Eu(III) and Gd(III) complexes with substituted 2-cinnamoyl-1,3-indandione ligands / I.Neibolte, M.Plotniece, V.Kampars // Abstracts of Riga Technical University 54th International Scientific Conference. Section: Material Science and Applied Chemistry (Riga, Latvia, Oct.14-16, 2013) / Riga Technical University. Faculty of Material Science and Applied Chemistry. - Riga, 2013. - P.15.

Studies of formation and characterisation of liposomes formed by cationic 1,4-dihydropyridine amphiphile in various medias [Elektroniskais resurss] / M.Plotniece, O.Petricenko, K.Pajuste ...[et al.] // 27th Conference of the European Colloid and Interface Society (Sofia, Bulgaria, Sept.1-6, 2013) : Abstracts [Elektroniskais resurss]. - Sofia, 2013. - 1 p. - Resurss aprakstīts 2014.g. 18.febr. - Pieejas veids: Tīmeklis WWW.URL: http://ecis2013.org/media/docs/COST_1101_P.pdf

Studies of preparation and stability of liposomes formed by 1,1,-[(3,5-didodeciloxycarbonyl)-4-phenyl-1,4-dihydropyridine-2,6-diil)-dimethylen] bispyridinium dibromide / M.Plotniece, K.Pajuste, M.Rucins ...[et al.] // 2nd International Symposium on Materials Science and Engineering Technology (IMSET-2013) (Guangzhou, China, June 27-28, 2013) : Abstract Book. - Guangzhou, 2013. - P.7.

Nonlinear optical chromophores with 1,3-indanedione moiety : [abstract] / V.Kampars, P.Pastors, M.Plotniece ...[et al.] // Riga Technical University 53rd International Scientific Conference dedicated to the 150th anniversary and the 1st Congress of World Engineers and Riga Polytechnical Institute / RTU Alumni (Rīga, 2012.g. 11.-12.okt.). - Rīga, 2012. - 53.lpp.

Studies of nanoaggregates formed by 1,4-dihydropyridine amphiphiles possessing antiradical activity / O.Petricenko, B.Skrivele, M.Plotniece ...[et al.] // 26th Conference of the European Colloid and Interface Society (ECIS 2012) (Malmö/Lund, Sweden, Sept.2-7, 2012) : Abstracts Book. - Malmö/Lund, 2012. - P.243.

Synthesis and studies of amphiphilic self-assembling 1,4-didydropyridines containing conjugated moieties / K.Pajuste, B.Skrivele, M.Plotniece ...[et al.] // International Conference on Organic Synthesis "Balticum Organicum Syntheticum (BOS 2012)" (Tallinn, Estonia, July 1-4, 2012) : Abstract Book. - Tallinn, 2012. - P.153.

Synthesis and studies of new gene delivery agents on base of cationic 1,4-dihydropyridine derivatives / K.Kore, A.Vezane, M.Plotniece ...[et al.] // International Conference in Pharmacology "Targeting Cellular Regulatory Systems" (Riga, Latvia, Apr.20-21, 2012) : Abstract Book. - Riga, 2012. - P.46.

Synthesis and studies of properties of 1,4-dihydropyridine amphiphiles / M.Rucins, K.Pajuste, M.Plotniece ...[et al.] // International Conference on Organic Synthesis "Balticum Organicum Syntheticum (BOS 2012)" (Tallinn, Estonia, July 1-4, 2012) : Abstract Book. - Tallinn, 2012. - P.160.

Synthesis of novel N-propargyl substituted 1,4-dihydropyridene derivatives as potential neuroprotective agents / K.Pajuste, D.Kaldre, M.Plotniece ...[et al.] // International Conference on Organic Synthesis "Balticum Organicum Syntheticum" (BOS 2012) (Tallinn, Estonia, July 1-4, 2012) : Abstract Book. - Tallinn, 2012. - P.152.

Jaunu organisko hromoforu sintēze un to raksturojumi / V.Kampars, J.Kreicberga, M.Plotniece ...[u.c.] // Apvienotais Pasaules latviešu zinātnieku 3. kongress un Letonikas 4. kongress "Zinātne, sabiedrība un nacionālā identitāte" (Rīga, 2011.g. 24.-27.okt.) : sekcija "Tehniskās zinātnes" : tēžu krājums / Rīgas Tehniskā universitāte. - Rīga, 2011. - 90.lpp.

Self-assembling compounds on base of amphiphilic 1,4-dihydropyridine derivatives : studies of biological properties and characterisation of their formed nanoparticles / M.Gosteva, O.Petricenko, M.Plotniece ...[et al.] // 25th Conference of the European Colloid and Interface Society (ECIS 2011) (Berlin, Germany, Sept.4-9, 2011) : Abstracts Book. - Berlin, 2011. - P.145.

Studies of self-assembling, gene delivery and antioxidant properties of polyfunctional pyridinium compounds on base of amphiphilic 1,4-dihydropyridine derivatives / B.Skrivele, K.Pajuste, M.Plotniece ...[et al.] // Workshop of COST D43 "Functionalized Materials and Interfaces" (Madrid, Spain, March 30-Apr.1, 2011) : Abstract Book. - Madrid, 2011. - P.64.

Synthesis and studies of amphiphilic self-assembling 1,4-didydropyridines containing conjugated moieties / K.Pajuste, M.Rucins, M.Plotniece ...[et al.] // Abstracts of the 52nd International Scientific Conference of Riga Technical University. Section: Material Science and Applied Chemistry (Riga, Latvia, Oct.13-15, 2011) / Riga Technical University. Faculty of Material Science and Applied Chemistry. - Riga, 2011. - P.36.

The condensation reactions of n-(indan-1,3-dion-2-yl)-4-methylpyridinium betaine with aromatic aldehydes / V.Kampars, L.Vesjolaja, M.Plotniece ...[et al.] // Abstracts of the 52nd International Scientific Conference of Riga Technical University. Section: Material Science and Applied Chemistry (Riga, Latvia, Oct.13-15, 2011) / Riga Technical University. Faculty of Material Science and Applied Chemistry. - Riga, 2011. - P.19.

Influence of solvents on the alkylation of 4-(3-pyridyl) group of 1,4-dihydropyridine / K.Pajuste, D.Kaldre, M.Plotniece ...[et al.] // International Conference on Organic Synthesis "Balticum Organicum Syntheticum (BOS 2010)" (Riga, Latvia, June 27-30, 2010) : Abstract Book. - Riga, 2010. - P.155.

Piterāne, Kristīne. N-(Indan-1,3-dion-2-yl)-4-nitropyridinium Betaine / K.Piterane, M.Plotniece, V.Kampars // International Conference on Organic Synthesis "Balticum Organicum Syntheticum (BOS 2010)" (Riga, Latvia, June 27-30, 2010) : Abstract Book. - Riga, 2010. - P.166.

Teivena, K. Synthesis of N-(Indan-1,3-dion-2-yl)-4-nitropyridinium Betaine / K.Teivena, M.Plotniece, V.Kampars // 51st International Scientific Conference of Riga Technical University (Riga, Latvia, Oct.15, 2010) : Abstract Book. - Riga, 2010. - Poster No.PO53.

Contacts

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Colleagues

Santa Purviņa
Head of the Department, Deputy Chair
Maija Dambrova
Academic Staff
Dace Bandere
Dean, Head of the Department, Head of Study Programme, Academic Staff
Baiba Mauriņa
Vice-Dean, Head of Study Programme, Academic Staff
Elita Poplavska
Head of the Department, Leading Researcher
Pāvels Sudmalis
Academic Staff, Researcher
Inga Urtāne
Acting Head of Department, Academic Staff