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Work experience

2010 - Present

Senior-consultant

Oncohaematology Department of Children ,University Clinical Hospital

1999 - Present

Head

Oncohaematology Department of Children University Clinical Hospital

lecturer's permit, lecturer in Paediatrics, in charge of Children Oncohaematology residency programme.​​

1990 - 1999

paediatrician

Latvian Children Clinical Hospital

1985 - 1988

Nurse

Riga Children Hospital "Gailezers"

Education and training

2003

certified children oncohaematologist

Latvian Medical Association

1994

certified paediatrician

Latvian Medical Association

1989 - 1991

clinical ordinature (advanced residency) in Paediatrics

Riga Medical Institute

1982 - 1988

doctor - pediatrician

Riga Medical Institute

1982

Riga Secondary School Nr.51

Achievements

Continuing education a.o. qualification upgrade


ADDITIONAL EDUCATION

2011Philadelphia Children Hospital Course in children oncology – haematology, Saltsburg, Austria

2007 NOPHO educational course "Non-neoplastic haematology", Palanga, Lietuva.

2006 NOPHO educational course "Leukemias lymphomas and histiocitosis in childhood", Rīga

Philadelphia Children Hospital Course in children oncology – haematology, Saltsburg, Austria

2nd Advanced ICAS Training Course on "Blood Stem Cell Transplantation". University of Ulm, Germany.

Russian-American children oncohematology School course

2005.g. VII-VIII

training in Freiburg University Children Clinic, Children Oncohaematology Dpt.

EHA-CME Course on Children oncohaematology, Sestri Levante, Italy

SIOP-ESO-ASPO Course on Children Haematology, Cairo, Egypt

SIOP-ESO-ASPO Course on Children Haematology, Porto, Portugal

ESMO course 'Basic Medical Oncology", Riga

postgraduate courses on Children Oncology, Oncology Centre, Moscow, RF

1996.g VI-VIII,

training in Munster University Clinic, Children Oncohaematology


Lectured study course

Basics of Paediatrics (Haematopoiesis, Endocrine, Connective Tissue, Cardiovascular Systems)

Paediatric Diseases (Neonatology, Endocrinology, Cardiology, Rheumatology, Gastroenterology, Pulmonology, Nephrology, Paediatric Infectious Diseases)

Paediatric Diseases III (Neonatology, Paediatric Endocrinology, Paediatric Haematology)

Paediatric Diseases IV

Projects

"Typing of acute leukaemias in children: new diagnostic and prognostic correlations"

"Particular features of epidemiology of childhood oncological diseases in Latvia."

Memberships

since 2003

Member of Latvian Association of Children Oncohaematologists, the Association's Chairperson

since 1994

Member of Latvian Association of Paediatricians

Publications

Research articles​​

Analysis of possible genetic risk factors contributing to development of childhood acute lymphoblastic leukaemia in the Latvian population / M.Kreile, L.Piekuse, D.Rots, Z.Dobele, Z.Kovalova, B.Lace // Archives of Medical Science - Vol.12, No.3 (2016, June), p.479-485. - Starptautiski citējamā izdevumā.

Dzelzs pārslodze bērniem ar hematoonkoloģiskām slimībām un dzelzi saistošu preparātu nozīmēšanas nepieciešamība / Ž.Kovaļova, Z.Višņevska-Preciniece, M.Grūtupa ...[u.c.] // Latvijas Ārsts. - Nr.3 (2015, marts), 55.-60.lpp.

Akūtas pre-B šūnu limfoblastu leikozes bērnu vecumā attīstības riska saistība ar polimorfismiem MDR1 un IKZF1 gēnā / M.Kreile, L.Piekuse, Ž.Kovaļova ...[u.c.] // Zinātniskie raksti : 2013.g. medicīnas nozares pētnieciskā darba publikācijas / Rīgas Stradiņa universitāte. - Rīga, 2014. - 391.-396.lpp.

Lack of association between polymorphisms in genes MTHFR and MDR1 with risk of childhood acute lymphoblastic leukemia / M.Kreile, D.Rots, L.Piekuse, Z.Kovalova ...[et al.] // Asian Pacific Journal of Cancer Prevention. - Vol.15, No.22 (2014), p.9707-9711. - Starptautiski citējamā izdevumā.

Very high incidence of Fanconi anemia in Latvia / Z.Kovalova, S.Nikulshin, M.Grutupa ...[et al.] // Collection of Scientific Papers 2012 : Research articles in medicine & pharmacy / Rīga Stradiņš University. - Riga, 2013. - P.5-10.

Hemopoetic stem cell transplantation for pediatric hematological diseases in Latvia : preliminary results / Z.Kovalova, M.Grutupa, S.Nikulshin, D.Gardovska // Collection of Scientific Papers 2011 : Research articles in medicine & pharmacy / Rīga Stradiņš University. - Riga, 2012. - P.108-113.

Pediatric acute myeloid leukemia in Latvia : BFM-based treatment efficacy (1993-2010) / Z.Kovalova, M.Grutupa, S.Nikulshin, G.Medne // Collection of Scientific Papers 2011 : Research articles in medicine & pharmacy / Rīga Stradiņš University. - Riga, 2012. - P.100-107.

Uneven demographic and geographic distribution of childhood leukemias in Latvia / Z.Kovalova, J.Sergejeva, Z.Vishnevska-Preciniece, S.Nikulshin, D.Gardovska // Collection of Scientific Papers 2010 : Research articles in medicine & pharmacy / Rīga Stradiņš University. - Riga, 2011. - P.19-28.

Blast cell count in the blood of children with acute lymphoblastic leukemia : comparison of conventional cytology and flow cytometry / Z.Kovalova, M.Grutupa, Z.Vishnevska-Preciniece ...[et al.] // Research articles in medicine & pharmacy, 2009 / Rīga Stradiņš University. - Riga, 2010. - P.14-18.

CRP, IL6, PCT un LBP diagnostiskā nozīme sepses attīstības un neitropēnijas ilguma prognozēšanai pacientiem ar ļaundabīgiem audzējiem un febrilu neitropēniju / M.Grūtupa, I.Grope, J.Pavāre, Ž.Kovaļova, D.Gardovska, O.Rasnačs // Zinātniskie raksti : 2009.g. medicīnas nozares pētnieciskā darba publikācijas / RĪgas Stradiņa universitāte. - Rīga, 2010. - 37.-43.lpp.

Survival analysis of pediatric acute lymphoblastic leukemia in Latvia (1992-2007) / Z.Kovalova, O.Nikolajeva, S.Nikulshin, D.Gardovska // Research articles in medicine & pharmacy, 2009 / Rīga Stradiņš University. - Riga, 2010. - P.9-13.

Abstracts​​

Epidemiology of paediatric acute lymphoid leukemia in Latvia in 1988-2015 / S.Nikulshin, Z.Kovalova, V.Jakupcevica ...[et al.] // 2016.gada Zinātniskās konferences tēzes (Rīga, 2016.g. 17.-18.martā) / Rīgas Stradiņa universitāte. - Rīga, 2016. - 181.lpp.

Paediatric B-lymphoblastic lymphoma of bone : presentation of two cases of extremely rare entity / S.Nikulshin, M.Strassere, Z.Kovalova ...[et al.] // 2016.gada Zinātniskās konferences tēzes (Rīga, 2016.g. 17.-18.martā) / Rīgas Stradiņa universitāte. - Rīga, 2016. - 180.lpp.

Bone marrow cellularity in pediatric patients assessed by hematological analyzer Advia 2120i : normal ranges and clinical relevance / S.Nikulshin, S.Paule, Z.Kovalova ...[u.c.] // 2015.gada Zinātniskās konferences tēzes (Rīga, 2015.g. 26.-27.martā) / Rīgas Stradiņa universitāte. - Rīga, 2015. - 244.lpp.

Case report of fanconi anemia with three malignancies / M.Grutupa, Z.Kovalova, E.Cebura ...[et al.] // The 3rd Baltic Paediatric Congress (Riga, Latvia, Aug.19-21, 2015) : Abstracts. - Riga, 2015. - P.45.

Children ALL patients in Latvia during 10 years period (2006-2015) - cytogenetics aspects / Z.Kovalova, M.Kreile, S.Ozolina ...[et al.] // The 3rd Baltic Paediatric Congress (Riga, Latvia, Aug.19-21, 2015) : Abstracts. - Riga, 2015. - P.48.

Events analysis for pediatric ALL patients in Latvia over the 2006-2014 period / Z.Kovalova, S.Nikulshin, E.Cebura ...[et al.] // The 3rd Baltic Paediatric Congress (Riga, Latvia, Aug.19-21, 2015) : Abstracts. - Riga, 2015. - P.49.

Intracellular neutrophil myeloperoxidase level in papediatric oncological patients during chemotherapy : possible new tool for leukopenia management / S.Nikulshin, S.Kursite, Z.Kovalova ...[u.c.] // 2015.gada Zinātniskās konferences tēzes (Rīga, 2015.g. 26.-27.martā) / Rīgas Stradiņa universitāte. - Rīga, 2015. - 245.lpp.

Iron overload (IO) assessment in children with haematooncology diseases in Latvia / Z.Visnevska-Preciniece, Z.Kovalova, E.Cebura ...[et al.] // The 3rd Baltic Paediatric Congress (Riga, Latvia, Aug.19-21, 2015) : Abstracts. - Riga, 2015. - P.77.

Joints functionality and physical activity in paediatric haemophilia patients in Latvia / E.Cebura, Z.Kovalova, Z.Višņevska-Preciniece ...[et al.] // The 3rd Baltic Paediatric Congress (Riga, Latvia, Aug.19-21, 2015) : Abstracts. - Riga, 2015. - P.39.

Kovaļova, Žanna. Paediatric acute lymphoid leukemia in Latvia in 1988–2014 / Z.Kovalova, S.Nikulshin, K.Latgale // 2015.gada Zinātniskās konferences tēzes (Rīga, 2015.g. 26.-27.martā) / Rīgas Stradiņa universitāte. - Rīga, 2015. - 249.lpp.

Kovaļova, Žanna. Pediatric acute lymphoblastic leukemia in Latvian children in 1988-2014 : [abstract] / Z.Kovalova // Nordic Society of Paediatric Haematology and Oncology (NOPHO) 33rd Annual Meeting (Oulu, Finland, May 23-26, 2015). - Oulu, 2015. - P.104.

Level of vitamin D and bone turnover markers in children with haemophilia in Latvia / Z.Kovalova, M.Grūtupa, E.Cebura ...[et al.] // Haemophilia. - Vol.21, Suppl.2 (2015, Febr.), p.58. - Starptautiski citējamā izdevumā.

Results of joint's changes evaluation in paediatric haemophilia patients in Latvia / E.Cebura, Z.Kovalova, M.Grūtupa ...[et al.] // Haemophilia. - Vol.21, Suppl.2 (2015, Febr.), p.47. - Starptautiski citējamā izdevumā.

Joints health of paediatric haemophilia patients in Latvia Z.Kovalova, E.Cebura, M.Grutupa ...[et al.] // 9th Baltic Conference of Hematology (BCH) (Vilnius, Lithuania, Apr.24-26, 2014) : Final Programme and Abstract Book. - Vilnius, 2014. - P.28-29.

Multiparameter flow cytometry and routine microscopy for detecting peripheral blasts in pediatric acute lymphoblastic leukemia : a comparative study / S.Nikulshin, Z.Kovalova, I.Tolstikova ...[et al.] // 9th Biennial Childhood Leukemia Symposium (Prague, Czech Republic, Apr.28-29, 2014) : Abstracts Book. - Prague, 2014. - P.64.

Ņikuļšins, Sergejs. Pediatric ALL phenotype defined by flow : clinical correlations / S.Nikulshin, Z.Kovalova, D.Gravele // 9th Baltic Conference of Hematology (BCH) (Vilnius, Lithuania, Apr.24-26, 2014) : Final Programme and Abstract Book. - Vilnius, 2014. - P.60.

Paediatric chronic myelogenous leukaemia presenting as B cell acute lymphoblastic leukaemia / Z.Kovalova, A.Uzars, I.Rudaka ...[et al.] // 2014.gada Zinātniskās konferences tēzes (Rīga, 2014.g. 10.-11.aprīlī) / Rīgas Stradiņa universitāte. - Rīga, 2014. - 277.lpp.

Pediatric CML in Latvia in 1994-2013 : high incidence and good survival / S.Nikulshin, Z.Kovalova, L.Kundzina ...[et al.] // 9th Baltic Conference of Hematology (BCH) (Vilnius, Lithuania, Apr.24-26, 2014) : Final Programme and Abstract Book. - Vilnius, 2014. - P.57.

Polymorphisms in gene ARID5B and risk of childhood AAL in Latvia / M.Kreile, L.Piekuse, Z.Kovalova ...[et al.] // 9th Baltic Conference of Hematology (BCH) (Vilnius, Lithuania, Apr.24-26, 2014) : Final Programme and Abstract Book. - Vilnius, 2014. - P.39-40.

Secondary AML arising 8 months after hereditary retinoblastoma / Z.Kovalova, S.Nikulshin, M.Grutupa ...[et al.] // 9th Baltic Conference of Hematology (BCH) (Vilnius, Lithuania, Apr.24-26, 2014) : Final Programme and Abstract Book. - Vilnius, 2014. - P.57-58.

Viena nukleotīda polimorfismu, kas lokalizēti gēnos IKZF1, ARID5B, MDR1 un CEBPE, saistība ar akūtu limfoblastu leikozi bērnu vecumā / M.Kreile, L.Piekuse, D.Rots, A.Zariņa, Ž.Kovaļova ...[u.c.] // 2014.gada Zinātniskās konferences tēzes (Rīga, 2014.g. 10.-11.aprīlī) / Rīgas Stradiņa universitāte. - Rīga, 2014. - 248.lpp.

Association between snp rs 4132601 in gene IKZF1 region and childhood acute lymphoblastic leukemia / M.Kreile, L.Piekuse, A.Zarina, Z.Kovalova ...[et al.] // European Journal of Human Genetics. - Vol.21, Suppl.2 (2013, June), p.536. - Starptautiski citējamā izdevumā.

Blast cell phenotype defined by flow cytometry correlates with clinical features and prognosis in pediatric acute lymphoblastic leukemia / A.Kuzina, S.Nikulshin, Z.Kovalova ...[et al.] // 2013.gada Zinātniskās konferences tēzes (Rīga, 2013.g. 21.-22.martā) / Rīgas Stradiņa universitāte. - Rīga, 2013. - 230.lpp.

Flow cytometry is significantly more sensitive than routine microscopy for detecting peripheral blasts in pediatric acute lymphoblastic leukemia / I.Shakalova, S.Nikulshin, Z.Kovalova ...[et al.] // 2013.gada Zinātniskās konferences tēzes (Rīga, 2013.g. 21.-22.martā) / Rīgas Stradiņa universitāte. - Rīga, 2013. - 222.lpp.

Prophylactic use of rFVIIa for hemophilia B patient with high-titer inhibitors - case report / Z.Kovalova, M.Grūtupa, E.Cebura ...[et al.] // Haemophilia. - Vol.19, Suppl.2 (2013, Febr.), p.65. - Starptautiski citējamā izdevumā.

A case of genetically proven familial hemophagocytic lymphohistiocytosis / Z.Kovalova, I.Melderis, D.Gardovska ...[et al.] // 2012.gada Zinātniskās konferences tēzes (Rīga, 2012.g. 29.-30.martā) / Rīgas Stradiņa universitāte. - Rīga, 2012. - 224.lpp.

Auziņa, Ilona. Rare mixed type germ-cell tumour in a 5-month old girl / I.Auzina, G.Medne, Z.Kovalova // The 12th Conference of the Baltic Association of Paediatric Surgeons (Riga, Latvia, May 17-19, 2012) : Final programme and abstracts / Riga Stradiņš University, University Children's Hospital of Latvia. - Riga, 2012. - P.102.

Evaluation of 8-color flow cytomery EuroFlow protocol for detection of minimal residual disease in pediatric acute lymphoid leukemia / S.Nikulshin, Z.Kovalova, D.Gardovska ...[et al.] // 2012.gada Zinātniskās konferences tēzes (Rīga, 2012.g. 29.-30.martā) / Rīgas Stradiņa universitāte. - Rīga, 2012. - 223.lpp.

Familial hemophagocytic lymphohistiocytosis : presentation of a genetically proven case / Z.Kovalova, I.Melderis, D.Gardovska ...[et al.] // 8th Baltic Conference of Hematology (Tallinn, Estonia, Apr.12-14, 2012) : Abstract Book. - Tallinn, 2012. - P.63-64.

Kovaļova, Žanna. Fanconi anemia in Latvia : unusually high incidence in pediatric population / Z.Kovalova, M.Grutupa, S.Nikulshin // 8th Baltic Conference of Hematology (Tallinn, Estonia, Apr.12-14, 2012) : Abstract Book. - Tallinn, 2012. - P.47.

Pulmonary involvement in paediatric multisystem Langerhans cell histiocytosis : a case report / A.Lacis, Z.Kovalova, G.Medne, Z.Abola // The 12th Conference of the Baltic Association of Paediatric Surgeons (Riga, Latvia, May 17-19, 2012) : Final programme and abstracts / Riga Stradiņš University, University Children's Hospital of Latvia. - Riga, 2012. - P.100.

SNP rs4132601 as a possible risk allele of acute lymphoblastic leukaemia development in children / M.Kreile, L.Piekuse, A.Krumina ...[et al.] // European Journal of Human Genetics. - Vol.20, Suppl.1 (2012, June), p.157-158. - Starptautiski citējamā izdevumā.

Unexpectedly high incidence of fanconi anemia in Latvia : [abstract] / Z.Kovalova, S.Nikulshin, A.Dzalbs, M.Grutupa // Haematologica. - Vol.97, Suppl.s3 (2012), p.S37 - Starptautiski citējamā izdevumā.

Auziņa, Ilona. Reti sastopams, jaukta tipa germinogēns audzējs 5 mēnešus vecai meitenītei (ICD-0, kods 9085/3) / I.Auziņa, G.Medne, Ž.Kovaļova // 6. Latvijas Ginekologu un dzemdību speciālistu kongress & 4. RCOG/Latvijas Ginekologu un dzemdību speciālistu asociācijas konference : tēzes un programma = 6th Congress of Latvian Gynecologists and Obstetricians & 4th Joint Royal College of Obstetricians and Gynaecologists (RCOG)/Latvian Association of Gynecologists and Obstetricians Eurovision Conference : abstracts and programme (Rīga, 2011.g. 13.-15.okt.). - Rīga, 2011. - 91.lpp.

Grūtupa, Marika. Fankoni anēmijas mūsdienu diagnostikas un ārstēšanas iespējas Latvijā / M.Grūtupa, Ž.Kovaļova, S.Ņikuļšins // 2011.gada Zinātniskās konferences tēzes (Rīga, 2011.g. 14.-15.aprīlī) / Rīgas Stradiņa universitāte. - Rīga, 2011. - 252.lpp.

Bērnu akūtas limfoblastu leikozes Latvijā : citoģenētisko un molekulārģenētisko aberāciju pētījums / Z.Kovaļova, I.Grīviņa, N.Proņina ...[u.c.] // 2010.gada Zinātniskās konferences tēzes (Rīga, 2010.g. 18.-19.martā) / Rīgas Stradiņa universitāte. - Rīga, 2010. - 233.lpp.

BFM treatment results for pediatric acute lymphoblastic leukemia (ALL) in Latvia during 1992-2009 / Z.Kovalova, O.Nikolajeva, D.Gardovska ...[u.c.] // 2010.gada Zinātniskās konferences tēzes (Rīga, 2010.g. 18.-19.martā) / Rīgas Stradiņa universitāte. - Rīga, 2010. - 232.lpp.

CML in an infant treated with combined CT, imatinib and BMT / Z.Kovalova, A.Andrejeva, I.Voitovica ...[et al.] // 7th Baltic Conference of Hematology (Tartu, Estonia, May 20-22, 2010) : Abstract Book. - Tartu, 2010. - P.43.

CML presenting as primary blast phase in a pediatric patient / Z.Kovalova, S.Lejniece, G.Medne ...[et al.] // 7th Baltic Conference of Hematology (Tartu, Estonia, May 20-22, 2010) : Abstract Book. - Tartu, 2010. - P.44.

Incidence of cytogenetic aberrations in pediatric acute lymphoblastic leukemia (ALL) in Latvia / I.Grivina, Z.Kovalova, S.Kursite, S.Nikulshin // Haematologica. - Vol.95, Suppl.2 (2010, June), p.680-681. - Starptautiski citējamā izdevumā.

Langerhans cell histiocytosis in an infant complicated by fatal macrophage activation syndrome / Z.Kovalova, A.Andrejeva, I.Voitovica ...[et al.] // 7th Baltic Conference of Hematology (Tartu, Estonia, May 20-22, 2010) : Abstract Book. - Tartu, 2010. - P.34.

Pediatric acute lymphoblastic leukemia (ALL) in Latvia in 1992-2009 : epidemiology and BFM results / Z.Kovalova, D.Gardovska, A.Andrejeva ...[et al.] // 7th Baltic Conference of Hematology (Tartu, Estonia, May 20-22, 2010) : Abstract Book. - Tartu, 2010. - P.42.

Pediatric ALL in Latvia in 1992-2009 and overview of BFM treatment / Z.Kovalova, D.Gardovska, A.Andrejeva ...[et al.] // 7th Bi-Annual Childhood Leukemia Symposium (Antalya, Turkey, Oct.4-6, 2010) : Abstract Book. - Antalya, 2010. - P.101.

T-precursor leukemia/lymphoma in a patient with Nijmegen breakage syndrome / Z.Kovalova, I.Voitovica, A.Andrejeva ...[et al.] // 7th Baltic Conference of Hematology (Tartu, Estonia, May 20-22, 2010) : Abstract Book. - Tartu, 2010. - P.61.

Contacts

Colleagues

Jānis Gardovskis
Head of the Unit, Academic Staff, Chair of the Senate
Ilze Grope
Dean, Academic Staff
Sandra Lejniece
Dean, Head of Study Programme
Gunta Lazdāne
Academic Staff, Director
Edvīns Miklaševičs
Academic Staff, Director
Gunta Ancāne
Head of the Department, Academic Staff
Maija Eglīte
Head of the Department, Academic Staff
Dace Gardovska
Head of the Department, Academic Staff, Director of Strategic Relations
Ilona Hartmane
Academic Staff
Regīna Kleina
Academic Staff
Juta Kroiča
Head of the Department, Academic Staff, Deputy Chair of the Senate
Gaida Krūmiņa
Academic Staff
Guna Laganovska
Head of the Department, Academic Staff
Ināra Logina
Academic Staff
Gunta Purkalne
Academic Staff, Leading Researcher
Ilze Štrumfa
Head of the Department, Academic Staff