Indra Miķelsone

Work experience

Education and training

Achievements

Continuing education a.o. qualification upgrade

13.06.-06.08.2016. Online courses of "Advanced Neurobiology I", organized by Peking University; Certificate

01.06.2016. RSU PIC organized lecture/seminar "Kanādas Britu Kolumbijas universitātes pieredze flipped classroom īstenošanā". Lektors Asoc.prof. Andis Klegeris; Apliecinājums Nr. 2016/216, 4 ak./st.

26.05.2016. RSU PIC organised courses of "Europass dokumentu portfolio"; Apliecinājums Nr.2016/314; 3 ak./st.

17.-18.03.2016. Riga Stradiņš University 15.Scientific conference; Certificate

03.10.2014. Thermo Fisher Scientific "Days of Science 2014" held in Riga; Certificate

10.-11.05.2013. Internationale Concerence "1st Meeting of the Baltic Physiological Societies" held in Kaunas, ​Lithuania; Certificate No. PS-10-148-16049; 12 c/p

29.-30.03.2012. Riga Stradiņš University 11.Scientific Conference; Certificate​.

26.-29.07.2011. European Atherosclerosis Society organized congress "79th Annual Congress of the European Atherosclerosis Society" Gothenburg, Sweden; Certificate

01.03.-21.05.2011. ERASMUS study practice in Maastricht (The Netherlands), The Laboratory for Metabolism and Vascular Medicine, Cardiovascular Research Institute Maastricht (CARIM).

14.-15.04.2011. Riga Stradiņš University 10.Scientific Conference; Certificate​.

23.-24.09.2010. Centro Nacionale Investigaciones Cardiovasculares organized Conference/Workshop "New insights into cell & tissue interactions in cardiovascular development and disease" Madrid, Spain; Certificate

Field of research

• Cardiovascular disease risk factors and their detection and possible prevention;
• Metabolic syndrome, prediabetes, diabetes;
• Arterial hypertension;
• inflammatatory biomarkers (cytokines, growth factors) and oxidative stress influence to the microvasculature; significance of oxidative stress to the ageing processes;
• Exogenous factors influence to the ageing processes; its evaluation/ detection and procedure complex to reduce this process.

Lectured study course

Adaptation of Bodily Functions

Normal Physiology

Normal Physiology and Neurophysiology

Physiology

Supervised and reviewed student research papers

Supervised:

course work: 1

bachelor's theses: 1

Consultant :

bachelor's theses: 1

Projects

Senior researcher, project manager; «Pranamat ECO akupresūras paklājiņa lokāla ietekme uz mikrocirkulācijas intensitātes, vielmaiņas un seruma neiropeptīdu koncentrācijas izmaiņām pacientiem ar mugurkaulāja spondilozi». Līgumpētījuma Nr. LIG/INT/2013-24, LU reģ.Nr. 2885 (2013 – 2014).

Researcher; «Diabēta un sirds-asinsvadu slimību farmakoģenētika, zāļu

mērķreceptoru testēšana». Projekts Nr.2010. 10-4/VPP-4, LU projekts Y3-26513-003 (2010 – 2012).

Researcher; «Saistība starp neopterīnu un iekaisuma biomarķieriem aterosklerozes pacientiem». Eiropas Ekonomikas zonas finanšu instrumenta grantu shēmas „Akadēmiskie pētījumi" apakšprojekts (sadarbībā ar Insbrukas Medicīnas Universitāti) Nr.EEZ08AP-5/2 (2009 – 2010).

Researcher; «Aptaukošanās izraisīto slimību un cukura diabēta mūsdienīgu agrīnās diagnostikas, profilakses un terapijas pasākumu izstrāde». Valsts pētījumu programmas Medicīnā Nr.8 LZP projekts 07-VP-ZP; LU projekts Y3-23464-003 (2007 – 2009).

Researcher; «Jaunas pieejas eksogēno veselības riska faktoru izraisīto traucējumu diagnostikā». IZM-LU proj. Nr. Y2-ZP80-003 (2007 – 2008).

Awards and recognitions

2004. Certificate of Recognition of the Rector of University of Latvia.

Publications

Research articles​​

Pranamat ECO akupresūras-masāžas paklājiņš. Efektivitātes novērtējums muguras sāpju novēršanai​ / I.Miķelsone, G.Krieviņa, Dz.Vāvere // DOCTUS – žurnāls ārstiem un farmaceitiem, jūnijs 2015, 6 [171], 48–51.

The acute effects of cigarette smoking on microvascular responsiveness and haemodynamic measurements in healthy male smokers / I.Mikelsone, P.Tretjakovs, A.Jurka ...[et al.] // Collection of Scientific Papers 2011 : Research articles in medicine & pharmacy / Rīga Stradiņš University. - Riga, 2012. - P.134-141.

The effect of chronic cigarette smoking on microvascular function, insulin resistance and inflammatory state / Mikelsone I., Bormane I., Simsone Z., Jurka A., Tretjakovs P // Environmental and Experimental Biology, 2011, 9: 23–28.

Circulating adhesion molecules, matrix metalloproteinase-9, plasminogen activator inhibitor-1, and myeloperoxidase in coronary artery disease patients with stable and unstable angina / Tretjakovs P.,Jurka A., Mikelsone I., Elksne K., Krieviņa G., Reihmane D., Verbovenko J., Bahs G // Clinica Chimica Acta, 2011.10, doi: 10.10164.

Relation of inflammatory chemokines to insulin resistance and hypoadipo-nectinemia in coronary artery disease patients / Tretjakovs P., Jurka A., Bormane I., Mackevics V., Mikelsone I., Balode L.,Reihmane D., Stukena I., Bahs G., Aivars J.I., Pirags V // European Journal of Internal Medicine, 2009, 20(7): 712–717.

Relation of Endothelial dysfunction and adipokines levels to insulin resistance in metabolic syndrome patients / Tretjakovs P., Jurka A., Bormane I., Miķelsone I., Reihmane D., Balode L., Jaunalksne I., Mackēvičs V., Stuķēna I., Bahs G., Lejnieks A., Aivars J.I., Pīrāgs V // Proceeding of the Latvian Academy of Sciences, 2009, 63(4-5): 222–227.

Alterations of tumor necrosis factor-alpha, endothelin-1 and vasomotor activity in patients with insulin resistance / Tretjakovs P., Jurka A., Bormane I., Miķelsone I., Reihmane D., Balode L., Aivars J.I., Stukēna I., Bahs G., Lejnieks A // RSU Zinātniskie raksti, Research articles in medicine&pharmacy, 2009.

Changes of plasminogen activator inhibitor-1, adhesion molecules, and endothelium-dependent vasodilatation and their relationship to insulin resistance in metabolic syndrome patients / Tretjakovs P., Jurka A., Bormane I., Miķelsone I., Reihmane D., Balode L., Aivars J.I., Stukēna I., Bahs G // RSU Zinātniskie raksti, Research articles in medicine&pharmacy, 2009.

Alteration of serum adhesion molecules and cutaneous endothelium-dependent vasodilatation in insulin resistant obese patients / Bormane I., Tretjakovs P., Jurka A., Mikelsone I., Reihmane D., Balode L., Elksne K., Aivars J.I., Stukena I., Cirule K., Bahs G., Pirags V // Acta Universitatis Latviensis, Biology, 2009, 753: 107–115.

Adipokines levels and markers of endothelial dysfunction in metabolic syndrome patients with insulin resistance / Tretjakovs P., Jurka A., Bormane I., Mikelsone I., Reihmane D., Balode L., Elksne K., Jaunalksne I., Mackevics V., Stukena I., Bahs G., Lejnieks A., Aivars J.I., Pirags V // Experimental and Clinical Endocrinology&Diabetes, 2009 (Nr ECED-08-2009-0242-Diabetes-Art).

Increased TNF-alpha levels and vasomotor dysfunction in hypertensive patients with insulin resistance / Jurka A., Tretjakovs P., Bormane I., Reihmane D., Mikelsone I., Jirgensons J., Bahs G., Martinsons A // Current Advances in Heart Disease, MEDIMOND International Proceedings, 2008: 219–223.

Abstracts​​

Alterations in cutaneous vasomotor responses and inflammatory state affected by chronic cigarette smoking and aging / I.Mikelsone, I.Bormane, Z.Simsone, P.Tretjakovs // Atherosclerosis Supplements. - Vol.12, N 1 (2011, June), p.182.

International Conferences

Relationship of Myeloperoxidase to Adiponectin and High-Density Lipoprotein (HDL) In Healthy Cigarette Smokers / I. Mikelsone, A. Plinta, A. Jurka, P. Tretjakovs // Poster presentation [Cardio P-1] / 1st Meeting of the Baltic Physiological Societies, Kaunas, Lithuania, May 10-11, 2013.

Alterations in cutaneous vasomotor responses and inflammatory state affected by chronic cigarette smoking and aging / Mikelsone I., Bormane I., Simsone Z., Tretjakovs P // Poster presentation 4.222 / The 79th European Atherosclerosis Society (EAS) Annual Congress, Gothenburg, Sweden, June 26-29, 2011.

The acute effects of cigarette smoking on microvascular reactivity and haemodynamic measurements in healthy young and adult men / Mikelsone I., Bormane I., Simsone Z., Tretjakovs P // Poster presentation P13 [4070] / The Annual Meeting of the Scandinavian Physiological Society, Bergen, Norway, August 12-14, 2011. // Acta Physiologica, 2011, 202 (685): P13 [4070].​

Evaluation of sE-selectin, insulin resistance and obesity influence to endothelium dependent vasodilatation in 2TDM patients / Mikelsone I., Bormane I., Jurka A., Tretjakovs P // Poster presentation No.7./ New insights into cell & tissue interactions in cardiovascular development and disease / Madrid, Spain, September 23 - 24, 2010// Centro Nacional de Investigaciones Cardiovasculares, Abstract Booklet, 2010.

Alterations of adipokines and cutaneous vasomotor responses in metabolic syndrome patients with insulin resistance / Mikelsone I., Jurka A., Bormane I, Reihmane D., Balode L., Aivars J.I., Tretjakovs P // Poster presentation P22. / The Annual Meeting of the Scandinavian Physiological Society. Uppsala, Sweden, August 14-16, 2009.// Acta Physiologica, 2009, V 196 (Suppl. 671: 111(P22).

Vasomotor dysfunction and alterations of adipokines in metabolic syndrome patients with insulin resistance / Mikelsone I., Jurka A., Reihmane D., Bormane I., Balode L., Aivars J.I., Tretjakovs P // Poster presentation 505 (P5AM-4-6 ). / The 14th International Congress of Physiological Sciences (IUPS). Kyoto, Japan, July 27 - August 1, 2009. // The Journal of Physiological Sciences, 2009, No. 59 (Suppl. 1): 505: P5AM-4-6.

Conferences and Seminars in Latvia

Miķelsone I. Pranamat ECO akupresūras masāžas paklājiņa efektivitātes novērtējums. Pētījuma rezultātu apkopojums: referāts / LU EKMI ikkadējais Zinātniskais seminārs, Rīga, 2014.

Miķelsone I. AGE's (advanced glycation end-products) akumulācija audos kā oksidatīvā stresa marķieris diabēta komplikāciju gadījumos: referāts / LU EKMI ikkadējais Zinātniskais seminārs, Rīga, 16.06.2011.

Miķelsone I., Jurka A., Bormane I., Tretjakovs P. Adipokīnu, iekaisuma citokīnu un endoteliālās funkcijas pārmaiņu saistība ar insulīna rezistenci metabolā sindroma pacientiem: referāts. / LU 68.konference, Bioloģijas sekcija, 2010.

Miķelsone I. Eksogēno faktoru ietekme uz endotēlija funkcijām: referāts. / LU 67.konference, Bioloģijas sekcija, 2009.

Miķelsone I. Osteorefleksoterapijas ietekme uz asins mikrocirkulāciju un vazomociju: referāts. / LU 66.konference, Bioloģijas sekcija, 2008.