.
Cell Metabolism
Study Course Description
Course Description Statuss:Approved
Course Description Version:5.00
Study Course Accepted:29.05.2020 09:22:59
| Study Course Information | |||||||||
| Course Code: | CFUBK_019 | LQF level: | Level 7 | ||||||
| Credit Points: | 2.00 | ECTS: | 3.00 | ||||||
| Branch of Science: | Clinical Medicine | Target Audience: | Medicine | ||||||
| Study Course Supervisor | |||||||||
| Course Supervisor: | Jeļena Krasiļņikova | ||||||||
| Study Course Implementer | |||||||||
| Structural Unit: | Department of Human Physiology and Biochemistry | ||||||||
| The Head of Structural Unit: | |||||||||
| Contacts: | Riga, 16 Dzirciema Street, cfbk rsu[pnkts]lv, +371 67061550 | ||||||||
| Study Course Planning | |||||||||
| Full-Time - Semester No.1 | |||||||||
| Lectures (count) | 2 | Lecture Length (academic hours) | 1 | Total Contact Hours of Lectures | 2 | ||||
| Classes (count) | 10 | Class Length (academic hours) | 3 | Total Contact Hours of Classes | 30 | ||||
| Total Contact Hours | 32 | ||||||||
| Study course description | |||||||||
| Preliminary Knowledge: | Anatomy, histology, physics, biology, physiology, biochemistry. | ||||||||
| Objective: | To promote knowledge acquisition of molecular processes in the organism at the cellular level including explanation of functional activity of the organism biochemical and physiological processes. | ||||||||
| Topic Layout (Full-Time) | |||||||||
| No. | Topic | Type of Implementation | Number | Venue | |||||
| 1 | Levels of Metabolism in Human cells. Enzymes: regulation of the Metabolism. Enzymes dependend reaction in Human: Gastrointestinal system, Circulation, Liver, Muscles, Myocardium, Locomotor system. Enzymopathias. Principles of enzyme-diagnostic. | Lectures | 1.00 | auditorium | |||||
| 2 | Regulation of Energy production in the cells. Hypoenergetical conditions. Complications. | Lectures | 1.00 | auditorium | |||||
| 3 | Enzymopathia related to proteins, carbohydrates and lipids macrometabolism. Changes in homeostasis. | Classes | 1.00 | laboratory | |||||
| 4 | Enzymopathia related to proteins, carbohydrates and lipids macrometabolism. Changes in homeostasis. | Classes | 1.00 | laboratory | |||||
| 5 | Enzymopathia related to proteins, carbohydrates and lipids macrometabolism. Changes in homeostasis. | Classes | 1.00 | laboratory | |||||
| 6 | Enzymodiagnostic. Principles. Classification. | Classes | 1.00 | laboratory | |||||
| 7 | Enzymopathia in proteins metabolism at organs and cell level. | Classes | 1.00 | laboratory | |||||
| 8 | Enzymopathia in carbohydrates metabolism at organs and cell level. | Classes | 1.00 | laboratory | |||||
| 9 | Enzymopathia in lipids metabolism at organs and cell level. | Classes | 1.00 | laboratory | |||||
| 10 | Types of hypoenergetical conditions in Human. Complications. | Classes | 1.00 | laboratory | |||||
| 11 | Practical work: research of the bioactive substances on digestive enzymes in norm and pathology. | Classes | 1.00 | laboratory | |||||
| 12 | Presentation of the students topics. Final test. | Classes | 1.00 | laboratory | |||||
| Assessment | |||||||||
| Unaided Work: | Independent studies of original sources, independent study report, practical research work. | ||||||||
| Assessment Criteria: | Short test evaluation includes the self-prepared theoretical topics, interpretation of clinical situation related to cell dysmetabolism. Multiple choice questions representing knowledge in enzymology, answers to additional individual questions associated to the topic. Examination / final assessment/ includes all topics covered during the course; written part with description of more topical dysmetabolic problem in human cell, oral question to evaluate understanding of relation between cell metabolism changes and clinical pathology by the changes in biochemical tests. | ||||||||
| Final Examination (Full-Time): | Exam | ||||||||
| Final Examination (Part-Time): | |||||||||
| Learning Outcomes | |||||||||
| Knowledge: | Upon completion of the course students will be able to name the all stages of macrometabolism from nutrients conversion in digestive system to the end products in the cell; They will know blockers and activators of digestive enzymes, related pathologies and dysmetabolical conditions; definition”Enzymopathy” and affected pathways of human metabolism as a result of cells enzymes malfunction. They will learn all regulating types of human homeostasis and cell metabolism by buffer system and hormonal disfunction. They will be able to interpret pathogenesis of major disease on the cell metabolism level and know main clinical pathologyes biochemical parametres of blood and urine changes. | ||||||||
| Skills: | Upon completion of the course students will be able to: - explain pathology changes of human macrometabolism based on digestive level; - explain how metabolical processes are crossing in the cells in norm and pathologies; - explain phases of detoxication of cells' waste products; - explain specificity of cell metabolism in different organs in physiological and non-physiological conditions. | ||||||||
| Competencies: | Upon completion of the course students will be able to: - assess how endo-, exogenic and epigenetic factors affect the cell metabolism; - assess how dysmetabolism in organs and cells level ca induce hypoenergetical conditions, free radicals related pathologies; - interpret relation between level of cell metabolism and biochemical parameters in blood and urine; - assess some clinical symptoms to macro-metabolism changes. | ||||||||
| Bibliography | |||||||||
| No. | Reference | ||||||||
| Required Reading | |||||||||
| 1 | Lieberman, M.A. and Peet, A. 2012. Marks's Basic Medical Biochemistry. 4th ed. Lippincott Williams& Wilkins | ||||||||
| 2 | PamelaC.C, Rishard A.H Biochemistry -Lippincots Illustrative Reviws, 4-th ed. Lippincott, Williams, 2005 | ||||||||
| 3 | Inflammation, Aging, and Oxidative Stress Bondy, Stephen C., Campbell, Arezoo (Eds.); 2016 | ||||||||
| 4 | Free Radicals in Human Health and Disease Rani, Vibha, Yadav, Umesh (Eds.); 2015 | ||||||||
| 5 | Oxidative Stress in Cancer Biology and Therapy Spitz, D.R., Dornfeld, K.J., Krishnan, K., Gius, D. (Eds.); © 2012 | ||||||||
| 6 | Redox Signaling and Regulation in Biology and Medicine Claus Jacob and Paul G. Winyard. (Eds.); April 2009 | ||||||||
| 7 | Olle Selenius, Brian Alloway, Jose A. Centeno et al. Essentials of Medical Geology. Impacts of the Natural Environment on Public Health. ELSEVIER Acad. Press. 2005., pp. 812. | ||||||||
| Additional Reading | |||||||||
| 1 | Ferrier D.R. Biochemistry, 6-th ed.: Lippincot , Willkins, 2011 | ||||||||
| 2 | Sinatra S.I. Metabolic cardiology ; Basic Health | ||||||||
| 3 | June H. Mcdermott. Antioxidant Nutrients: Current Dietary Recommendations and research update. | ||||||||
| 4 | Peter H. Proctor, Edwards S. Reynolds. Free Radicals and Disease in Man. | ||||||||
| 5 | Thomas M. Devlin. Textbook of biochemistry with clinical correlations 7e. 2011 | ||||||||
| Other Information Sources | |||||||||
| 1 | Journal „European Journal of Clinical Nutritions” | ||||||||
| 2 | Journal „Free Radicals in Biology and Medicine„ | ||||||||
| 3 | http://www.nutraingredients.com | ||||||||
