Methods of Instrumental Analysis

Study Course Description

Course Description Statuss:Approved

Course Description Version:8.00

Study Course Accepted:03.11.2022 08:25:17

Study Course Information
Course Code:		FKK_016		LQF level:		Level 7
Credit Points:		2.00		ECTS:		3.00
Branch of Science:		Basic Sciences of Medicine, including Pharmacy; Pharmacy		Target Audience:		Pharmacy
Study Course Supervisor
Course Supervisor:		Inga Urtāne
Study Course Implementer
Structural Unit:		Department of Pharmaceutical Chemistry
The Head of Structural Unit:
Contacts:		Riga, 16 Dzirciema Street, A-korp. 5.st. 502.kab., farmkkrsu[pnkts]lv, +371 67061544
Study Course Planning
Full-Time - Semester No.1
Lectures (count)		8	Lecture Length (academic hours)		2	Total Contact Hours of Lectures		16
Classes (count)		8	Class Length (academic hours)		2	Total Contact Hours of Classes		16
Total Contact Hours								32
Part-Time - Semester No.1
Lectures (count)		4	Lecture Length (academic hours)		4	Total Contact Hours of Lectures		16
Classes (count)		4	Class Length (academic hours)		4	Total Contact Hours of Classes		16
Total Contact Hours								32
Study course description
Preliminary Knowledge:
Physics, mathematics, organic chemistry, quantitative analysis.
Objective:
Promote acquisition of knowledge of the instrumental methods often used in pharmaceutical analysis and practical use of these methods.
Topic Layout (Full-Time)
No.	Topic			Type of Implementation		Number	Venue
1	Introductory lecture. Classification of instrumental analysis methods, applications for different samples and analytes.			Lectures		1.00	auditorium
				Classes		1.00	laboratory
2	UV / VIS / IS spectrometry.			Lectures		1.00	auditorium
				Classes		1.00	laboratory
3	Theoretical basis of potentiometry. Potentiometric titration, K. Fischer titration.			Lectures		1.00	auditorium
				Classes		1.00	laboratory
4	Thin layer chromatography and screening methods			Lectures		1.00	auditorium
				Classes		1.00	laboratory
5	Liquid chromatographic methods			Lectures		1.00	auditorium
				Classes		2.00	laboratory
6	Gas chromatographic methods			Lectures		1.00	auditorium
				Classes		1.00	laboratory
7	Mass spectrometric methods - Determination of organic matter			Lectures		1.00	auditorium
				Classes		1.00	laboratory
8	Mass spectrometry methods - element analyzes			Lectures		1.00	auditorium
Topic Layout (Part-Time)
No.	Topic			Type of Implementation		Number	Venue
1	Introductory lecture. Classification of instrumental analysis methods, applications for different samples and analytes.			Lectures		0.50	auditorium
				Classes		0.50	laboratory
2	UV / VIS / IS spectrometry.			Lectures		0.50	auditorium
				Classes		0.50	laboratory
3	Theoretical basis of potentiometry. Potentiometric titration, K. Fischer titration.			Lectures		0.50	auditorium
				Classes		0.50	laboratory
4	Thin layer chromatography and screening methods			Lectures		0.50	auditorium
				Classes		0.50	laboratory
5	Liquid chromatographic methods			Lectures		0.50	auditorium
				Classes		1.00	laboratory
6	Gas chromatographic methods			Lectures		0.50	auditorium
				Classes		0.50	laboratory
7	Mass spectrometric methods - Determination of organic matter			Lectures		0.50	auditorium
				Classes		0.50	laboratory
8	Mass spectrometry methods - element analyzes			Lectures		0.50	auditorium
Assessment
Unaided Work:
Individual work with literature to understand the essence of each method of analysis and its application. Practical lessons for individual analysis of video materials - preparation of the analyzed sample in spectrophotometry, chromatography, potentiometry; analysis and evaluation of results. Please fill in the study course survey, evaluating the existing course content and creating proposals for updating the course.
Assessment Criteria:
Analysis of analysis video materials and scientific publication (25%), tests during the study course (25%) and exam (50%).
Final Examination (Full-Time):		Exam (Written)
Final Examination (Part-Time):		Exam (Written)
Learning Outcomes
Knowledge:		Upon successful completion of the study programme students will be able to: • formulate and explain the theoretical basis of refractometry, spectrophotometry (UV and IR) and chromatography; • to distinguish and evaluate advantages, disadvantages and application possibilities of instrumental methods.
Skills:		Upon successful completion of the study program students will be able to: • to evaluate the methods necessary for testing the good of the medicinal product according to the physical and chemical properties of the substances; • use refractometry, UV and IR spectrophotometry, gas (GH) and solution (HPLC) chromatography to verify the identity and quantity of the substances; • use potentiometric titration for quantitative analysis of drug substances.
Competencies:		As a result of the study course students will be able to evaluate instrumental analysis methods and apply them in drug analysis.
Bibliography
No.	Reference
Required Reading
1	Watson, David G. Pharmaceutical Analysis : a textbook for pharmacy students and pharmaceutical chemists / David G. Watson ; with contribution by Bhavik A. Patel. 5th edition. Edinburgh [et al.] : Elsevier, 2021. vi, 462 lpp. (brošēts).
2	Drug Delivery Systems / edited by Rakesh K. Tekade. London : Academic Press an imprint of Elsevier, [2019], 2020. xiii, 777 lpp. Advances in pharmaceutical product development and research. (iesiets).
3	Water Extraction of Bioactive Compounds: From Plants to Drug Development. / edited by Herminia Domingues Gonsález, et.al. Amsterdam: Elsevier, 2017. xviii, 466 lpp.
Additional Reading
1	Handbook of Pharmaceutical Excipients / edited by Paul J. Sheskey, Bruno C. Hancock, Gary P. Moss, David J. Goldfarb. 9th edition. London; Philadelphia : Pharmaceutical Press; Washington, DC : American Pharmaceutical Association, 2020. xxxiv, 1262 lpp. (iesiets).
2	Gas chromatography: biochemical, biomedical and clinical applications. / Edited by Ray Clement. New York: Wiley, 1990. x, 393 lpp. Chemical analysis, vol. 111.
3	Instrumentation in Analytical Chemistry. 1988 – 1991. / Edited by Voress L. Washington: American Chemical Society, 1992.