Clinical Pharmacology

Study Course Description

Course Description Statuss:Approved

Course Description Version:6.00

Study Course Accepted:23.08.2021 15:58:56

Study Course Information
Course Code:		FLK_008		LQF level:		Level 7
Credit Points:		5.00		ECTS:		7.50
Branch of Science:		Clinical Medicine; Pharmacology		Target Audience:		Medicine
Study Course Supervisor
Course Supervisor:		Mārcis Zeibārts
Study Course Implementer
Structural Unit:		Department of Pharmacology
The Head of Structural Unit:
Contacts:		Riga, 13 Pilsoņu Street, block 4, Marcis[pnkts]Zeibartsrsu[pnkts]lv; Indra[pnkts]Dumbergarsu[pnkts]lv, +371 67613517
Study Course Planning
Full-Time - Semester No.1
Lectures (count)		0	Lecture Length (academic hours)		0	Total Contact Hours of Lectures		0
Classes (count)		14	Class Length (academic hours)		3	Total Contact Hours of Classes		42
Total Contact Hours								42
Full-Time - Semester No.2
Lectures (count)		0	Lecture Length (academic hours)		0	Total Contact Hours of Lectures		0
Classes (count)		13	Class Length (academic hours)		3	Total Contact Hours of Classes		39
Total Contact Hours								39
Study course description
Preliminary Knowledge:
Anatomy, physiology, propaedeutics, chemistry, biochemistry, microbiology, basics of pharmacology, introduction into clinical medicine and symptomatology of several diseases. Knowledge of the state language of Latvia.
Objective:
1. To acquire knowledge of basic issues of clinical pharmacology along with acquisition of the organ system pathology and diseases. 2. To acquire knowledge of mechanism of action of miscellaneous drugs and their use in treatment of diseases. 3. To promote knowledge of rational pharmacotherapy principles in clinical practice. 4. Gain knowledge of effects of drugs used in clinics on disease mechanisms and pathogenesis, the most suitable drug designation for an individual patient, dosing scheme and personalized treatment, assessment of risk-benefit ratio.
Topic Layout (Full-Time)
No.	Topic			Type of Implementation		Number	Venue
1	Introduction. General Pharmacology.			Classes		1.00	auditorium
2	Efferent pathway pharmacology. Cholinergic agents.			Classes		1.00	auditorium
3	Efferent pathway pharmacology. Adreneregic agents.			Classes		1.00	auditorium
4	Workshop in peripheral nervous system pharmacology.			Classes		1.00	auditorium
5	Antihypertensive drugs.			Classes		1.00	auditorium
6	Anti-anginal agents.			Classes		1.00	auditorium
7	Drugs for the treatment of chronic heart disease.			Classes		1.00	auditorium
8	Antiarrhythmic drugs.			Classes		1.00	auditorium
9	Workshop in cardiovascular system pharmacology.			Classes		1.00	auditorium
10	Pharmacology of the Central Nervous System (CNS) 1.			Classes		1.00	auditorium
11	Pharmacology of the Central Nervous System (CNS) 2.			Classes		1.00	auditorium
12	Pharmacology of the Central Nervous System (CNS) 3.			Classes		1.00	auditorium
13	Pharmacology of the Central Nervous System (CNS) 4.			Classes		1.00	auditorium
14	Workshop in Pharmacology of the CNS.			Classes		1.00	auditorium
15	Hypothalamic and Pituitary Hormones. Drugs affecting bone mineralization. Vitamine preparations.			Classes		1.00	auditorium
16	Pharmacology of agents affecting thyroid gland. Pharmacology of preparations used in Diabetes.			Classes		1.00	auditorium
17	Pharmacology of agents affecting reproductive system. Hormone replacement therapy.			Classes		1.00	auditorium
18	Pharmacology of adrenal gland hormones. Anti-inflammatory agents (steroids and nonsteroidal agents). DMARD. Antigout agents.			Classes		1.00	auditorium
19	Chemotherapeutic agents.			Classes		1.00	auditorium
20	Workshop in the pharmacology of metabolism affecting agents.			Classes		1.00	auditorium
21	Pharmacology of Respiratory System.			Classes		1.00	auditorium
22	Pharmacology of Gastrointestinal System.			Classes		1.00	auditorium
23	Pharmacology of preparations used in Urology and Ophthalmology.			Classes		1.00	auditorium
24	Pharmacology of preparations used in Haematology.			Classes		1.00	auditorium
25	Workshop in the pharmacology of drugs affecting the organ systems.			Classes		1.00	auditorium
26	Antimicrobial agents. Antibiotics. Synthetic antibacterial agents.			Classes		1.00	auditorium
27	Pharmacology of Anti-parasitic agents.			Classes		1.00	auditorium
Assessment
Unaided Work:
Acquisition of general and clinical pharmacology, evaluation of information about medicines, their application and use in therapeutic process, its sorting and analysing.
Assessment Criteria:
1. Regular tests during classes and a colloquium at the end of topic. 2. Final examination – the programme of the courses of Basics of pharmacology and Clinical pharmacology (MCQ).
Final Examination (Full-Time):		Exam (Written)
Final Examination (Part-Time):
Learning Outcomes
Knowledge:		On successful completion of the course the students will be able to describe different pharmacological groups, will be able to explain the use of medications' in practice, their mechanisms of action, side effects, contraindications, and usage characteristics; they will acquire basic knowledge to be able to discuss particular disorder pharmacotherapy, estimate drug combinations and doses.
Skills:		On successful completion of the course, students will be able to explain assess the mechanism of action of certain drugs, predict side effects, as well as be able to explain the effects of drugs used in clinic regarding to the mechanism and pathogenesis of the disease, to choose the most appropriate medication in a given situation in an appropriate dosing regimen and to evaluate treatment risks and benefits.
Competencies:		On successful completion of the course, students will be able to: • use their theoretical knowledge and expertise in basic and clinical pharmacology; • describe and compare preparations of different pharmacological groups; • formulate their mechanisms of action, indications and contra-indications, as well as side-effects; • use knowledge of pharmacotherapy and describe pharmacotherapeutic groups; • according to the specific situation, choose the most appropriate medications in individual dosages and to give prescription in order to provide optimum treatment for patient and for prevention of disease for the proportionate costs, justify and argue the opinion about treatment; • based on the data of evidence-based medicine, assess drug treatment according to age, gender and co-morbidity, medication choices, and evaluate the risk-benefit ratio; • collect and analyse data about medicines, their use in the process of the treatment; • show scientific approach to the topicalities as well as to be competent in specific literature.
Bibliography
No.	Reference
Required Reading
1	Lekciju materiāls RSU E-studijas
2	Goodman & Gilman's: The Pharmacological Basis of Therapeutics. 13th Ed. Laurence L. Brunton, et al. McGraw-Hill, 2017
3	Indulis Purviņš, Santa Purviņa. Praktiskā farmakoloģija. 4. Izdevums, ZIC, 2011, 896 lpp.
4	Basic & Clinical Pharmacology. Bertram G. Katzung. 14th Ed. McGraw-Hill Professional, 2017
Additional Reading
1	Pharmacotherapy: A Pathophysiologic Approach. 11th Ed., July 3, 2020; 2672 pages
2	Clinical Pharmacy and Therapeutics. Roger Walker, Clive Edwards. Churchill Livingstone, 2003, 937 lpp.
3	Introductory Clinical Pharmacology. Sally S. Roach, Susan M. Ford. Lippincott Williams & Wilkins, 2008, 800 lpp.
4	Clinical Pharmacology, 11th Ed. Peter N. Bennett, Morris J. Brown, Pankaj Sharma. Churchill Livingstone, 2012, 680 pages.
5	British National Formulary, BNF No. 63, March 2012
6	Drug Benefits and Risks: International Textbook of Clinical Pharmacology. Chris J. Van Boxtel. IOS Press, 2008, 821 lpp.
7	Pharmacotherapy Handbook. Barbara G Wells. McGraw-Hill Medical, October 10, 2011, 1164 pages \| ISBN-10: 0071748342
Other Information Sources
1	www.vm.gov.lv
2	www. EMCDDA.europa.eu/
3	www. euphix.org/
4	http://ec.europa.eu/health-eu/
5	http://www. haiweb.org/
6	Latvijas Zāļu valsts aģentūras Zāļu patēriņa statistika