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Clinical Pharmacology, Pharmacotherapy, Toxicology
Study Course Description
Course Description Statuss:Approved
Course Description Version:5.00
Study Course Accepted:25.01.2022 09:27:38
| Study Course Information | |||||||||
| Course Code: | FLK_048 | LQF level: | Level 7 | ||||||
| Credit Points: | 2.00 | ECTS: | 3.00 | ||||||
| Branch of Science: | Clinical Medicine; Pharmacology | Target Audience: | Medicine | ||||||
| Study Course Supervisor | |||||||||
| Course Supervisor: | Santa Purviņa | ||||||||
| Study Course Implementer | |||||||||
| Structural Unit: | Department of Pharmacology | ||||||||
| The Head of Structural Unit: | |||||||||
| Contacts: | Riga, 13 Pilsonu Street, Block No. 4, Santa[pnkts]Purvina rsu[pnkts]lv; Indra[pnkts]Dumbergarsu[pnkts]lv; +371 67613517 | ||||||||
| Study Course Planning | |||||||||
| Full-Time - Semester No.1 | |||||||||
| Lectures (count) | 3 | Lecture Length (academic hours) | 2 | Total Contact Hours of Lectures | 6 | ||||
| Classes (count) | 4 | Class Length (academic hours) | 3 | Total Contact Hours of Classes | 12 | ||||
| Total Contact Hours | 18 | ||||||||
| Full-Time - Semester No.2 | |||||||||
| Lectures (count) | 2 | Lecture Length (academic hours) | 2 | Total Contact Hours of Lectures | 4 | ||||
| Classes (count) | 3 | Class Length (academic hours) | 3 | Total Contact Hours of Classes | 9 | ||||
| Total Contact Hours | 13 | ||||||||
| Study course description | |||||||||
| Preliminary Knowledge: | Anatomy, physiology, pathology, biochemistry, basics of internal diseases, pharmacology. | ||||||||
| Objective: | To provide knowledge of specific pharmacotherapy in accordance with the pathology of the organ systems studied during the study course. To gain knowledge of the effect of therapeutic drugs on disease mechanisms and pathogenesis. The aim is to achieve that students are able to apply their knowledge of the mechanisms of action of drug substances and to integrate pharmacotherapeutic strategies in the treatment of a given case, to anticipate the course of events resulting from the treatment. Students should understand the mechanisms, indications and contraindications, adverse side effects, interactions, toxicity, and focus on the pharmacokinetic properties of each product. | ||||||||
| Topic Layout (Full-Time) | |||||||||
| No. | Topic | Type of Implementation | Number | Venue | |||||
| 1 | Chronic coronary heart disease, pharmacotherapy. Toxicity of agents used to treat CHD. Acute coronary syndrome, tactics in acute coronary syndrome. Anti-aggregants, anti-integrants, anticoagulants. Drug eluting stents. | Lectures | 1.00 | auditorium | |||||
| 2 | Classification of antihypertensive agents according to mechanism of action and site, their toxicity. Pharmacotherapy of hypertension, its justification. Treatment of hypertensive crises. Resistant hypertension, its treatment. Chronic heart failure, treatment. Acute heart failure (major clinical manifestations – pulmonary oedema, cardiogenic shock), pharmacological treatment. | Lectures | 1.00 | auditorium | |||||
| 3 | Classification of anti-arrhytmic agents, mechanism of action. Basic princips of pharmacological treatment of arrhythmias. Prevention of thromboembolic events. Pharmacotherapy of inflammatory heart diseases (endocarditis – infectious and rheumatic; pericarditis). | Lectures | 1.00 | auditorium | |||||
| 4 | Cardiovascular diseases, their pharmacological treatment. Mechanism of action, interaction, side-effects | Classes | 2.00 | computer room | |||||
| 5 | Clinical pharmacology of agents affecting gastrointestinal system. Pharmacotherapy for increased gastric secretion, peptic ulcer, Gastroesophageal reflux disease (GERD). Pharmacotherapy of IBS. Pharmacotherapy of inflammatory bowel diseases, mechanism of action. Clinical pharmacology of the agents affecting respiratory system. Pharmacotherapy respiratory diseases. | Classes | 1.00 | computer room | |||||
| 6 | Clinical pharmacology of agents that affect renal function. Pharmacotherapy of main syndromes of kidney damage (nephritic syndrome, nephrotic syndrome). Acute urinary tract infection (cystitis, pyelonephritis, acute urethral syndrome), treatment tactics. Chronic renal disease, pharmacotherapy. | Classes | 1.00 | computer room | |||||
| 7 | Hypothalamic and pituitary hormone preparations. Clinical pharmacology of medication affecting thyroid gland and parathyroid. Clinical pharmacology of medicines affecting bone mineralization. Vitamin preparations. Clinical pharmacology of drugs used in the treatment of diabetes mellitus. Principles of insulin therapy. | Lectures | 1.00 | auditorium | |||||
| 8 | Pharmacology of drugs affecting the adrenal cortex. Steroidal and non-steroidal anti-inflammatory drugs. Disease-modifying anti-rheumatic drugs (DMARD). Anti-gout agents. Spinal spondylosis, disc herniation with root irritation syndrome and pain syndrome, pharmacotherapy. Radiculopathies, their treatment. | Lectures | 1.00 | auditorium | |||||
| 9 | Sleep disorders, their treatment depending on the cause. Anti-anxiety agents, Antidepressants, their use in various indications. Specific features and differences of antidepressants. Psychotropic intoxication and drug overdose for suicide. Burnout syndrome, pharmacotherapy. Drugs to improve cognitive processes. Antipsychotic agents. Treatment of acute psychosis | Classes | 1.00 | computer room | |||||
| 10 | Antiepileptics. Antiparkinson's drugs. Strategy for treatment of delirium in somatic clinic. Stroke pharmacotherapy. | Classes | 1.00 | computer room | |||||
| 11 | Analgesics, co-analgesics. Chronic lower back pain and its treatment options. Soft tissue pain. Nociceptive, neuropathic and nociplastic (myofascial pain syndrome, psychogenic pain), their pharmacotherapy. Chronic pain syndrome and its pharmacotherapy. | Classes | 1.00 | computer room | |||||
| Assessment | |||||||||
| Unaided Work: | Reports, systematic reviews of specific medications, their application and use in the treatment process. | ||||||||
| Assessment Criteria: | During practical classes, simulation of clinical situations and modulation of therapy until a positive result is achieved. | ||||||||
| Final Examination (Full-Time): | Exam (Written) | ||||||||
| Final Examination (Part-Time): | |||||||||
| Learning Outcomes | |||||||||
| Knowledge: | Describe and explain the principles and pharmacokinetic properties of drug groups and active substances, indications, major adverse reactions, contraindications. Characterize and explain the major interaction risks and effects of drug groups on efficacy, toxicity (if applicable). | ||||||||
| Skills: | On completion of the study course, students will be able to describe preparations of pharmacotherapeutic groups, formulate their mechanisms of action, indications and contraindications, as well as side effects, justify and base their opinion on the chosen treatment, modulate the applied therapy in different clinical situations. To argue reasonably on the usefulness of a pharmacotherapeutic strategy in cases of particular disease pathology; to critically analyze the usefulness of pharmacotherapeutic strategies in the context of organ system diseases. | ||||||||
| Competencies: | On completion of the study course, students will be able to: 1. Use theoretical and practical knowledge and competence in clinical pharmacology and the use of medicinal products. 2. Choose the most appropriate medication according to the individual situation in an individualized dosage regimen to ensure optimal patient treatment and disease prevention. 3. Assess the risks and benefits of treatment. 4. Independently obtain, select and analyze information regarding medications, their use and use in the treatment process. 5. Demonstrate a scientific approach to solving topical issues, as well as have good knowledge of specific literature. | ||||||||
| Bibliography | |||||||||
| No. | Reference | ||||||||
| Required Reading | |||||||||
| 1 | RSU E-studiju vide | ||||||||
| 2 | Basic & Clinical Pharmacology. 14e Available from: https://accessmedicine-mhmedical-com.db.rsu.lv/book.aspx?bo… | ||||||||
| 3 | Medical Pharmacology and Therapeutics. 5e Available from: https://www-clinicalkey-com.db.rsu.lv/#!/browse/book/3-s2.0… | ||||||||
| 4 | Poisoning & Drug Overdose. 7e Available from: https://accessmedicine-mhmedical-com.db.rsu.lv/book.aspx?bo… | ||||||||
| 5 | Dynamed. Available from: https://www.dynamed.com/ | ||||||||
| 6 | Up To Date. Available from: https://www-uptodate-com.db.rsu.lv/contents/search | ||||||||
| Additional Reading | |||||||||
| 1 | Harrison's Principles of Internal Medicine. 20e Available from: https://accessmedicine-mhmedical-com.db.rsu.lv/book.aspx?bo… | ||||||||
| 2 | Basic Concepts in Pharmacology: What You Need to Know for Each Drug Class. 5e Available from: https://accessmedicine-mhmedical-com.db.rsu.lv/book.aspx?bo… | ||||||||
| 3 | Goodman & Gilman's: The Pharmacological Basis of Therapeutics. 13e Available from: https://accessmedicine-mhmedical-com.db.rsu.lv/book.aspx?bo… | ||||||||
| Other Information Sources | |||||||||
| 1 | https://www.drugbank.ca/ | ||||||||
| 2 | https://pubchem.ncbi.nlm.nih.gov/ | ||||||||
| 3 | https://accessmedicine-mhmedical-com.db.rsu.lv/updatesConte… | ||||||||
| 4 | ClinicalKey. Available from: https://www-clinicalkey-com.db.rsu.lv/#!/ | ||||||||
| 5 | Cochrane Library. Available from: https://www-cochranelibrary-com.db.rsu.lv/ | ||||||||
