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Biochemistry and Laboratory Diagnostics
Study Course Description
Course Description Statuss:Approved
Course Description Version:4.00
Study Course Accepted:14.03.2024 11:44:18
| Study Course Information | |||||||||
| Course Code: | SL_102 | LQF level: | Level 7 | ||||||
| Credit Points: | 2.00 | ECTS: | 3.00 | ||||||
| Branch of Science: | Clinical Medicine | Target Audience: | Life Science | ||||||
| Study Course Supervisor | |||||||||
| Course Supervisor: | Angelika Krūmiņa | ||||||||
| Study Course Implementer | |||||||||
| Structural Unit: | Statistics Unit | ||||||||
| The Head of Structural Unit: | |||||||||
| Contacts: | 23 Kapselu street, 2nd floor, Riga, statistika rsu[pnkts]lv, +371 67060897 | ||||||||
| Study Course Planning | |||||||||
| Full-Time - Semester No.1 | |||||||||
| Lectures (count) | 4 | Lecture Length (academic hours) | 2 | Total Contact Hours of Lectures | 8 | ||||
| Classes (count) | 8 | Class Length (academic hours) | 2 | Total Contact Hours of Classes | 16 | ||||
| Total Contact Hours | 24 | ||||||||
| Part-Time - Semester No.1 | |||||||||
| Lectures (count) | 4 | Lecture Length (academic hours) | 1 | Total Contact Hours of Lectures | 4 | ||||
| Classes (count) | 8 | Class Length (academic hours) | 1 | Total Contact Hours of Classes | 8 | ||||
| Total Contact Hours | 12 | ||||||||
| Study course description | |||||||||
| Preliminary Knowledge: | Knowledge in chemistry, human physiology, biology, mathematics, physics. | ||||||||
| Objective: | To facilitate the acquisition of theoretical knowledge about chemical processes in the human body in relation to its functions. To improve the understanding of modern laboratory diagnostic possibilities and their interpretation by providing information on the chemical composition of materials used in diagnostics. | ||||||||
| Topic Layout (Full-Time) | |||||||||
| No. | Topic | Type of Implementation | Number | Venue | |||||
| 1 | Carbohydrate metabolism – digestion and absorption of carbohydrates, glycogen metabolism (glycogenolysis, glycogenogenesis), glycolysis, pentose pathway, gluconeogenesis. Functions of carbohydrates in the human body. | Lectures | 1.00 | auditorium | |||||
| 2 | Lipid metabolism – digestion and absorption, lipolysis and lipogenesis, phospholipid and cholesterol metabolism, fatty acids and ketones. Functions of lipids in the human body. | Lectures | 1.00 | auditorium | |||||
| 3 | Protein metabolism: digestion and absorption, biosynthesis of amino acids and complex proteins. Functions of proteins in the human body. | Lectures | 1.00 | auditorium | |||||
| 4 | Possibilities of laboratory diagnostics: classification, material and methods used, their specificity and sensitivity. | Lectures | 1.00 | auditorium | |||||
| 5 | Complete blood count, blood biochemistry, blood culture, cytogenetic examination – indicators, meaning thereof, interpretation of changes. | Classes | 1.00 | auditorium | |||||
| 6 | Fecal examination: fecal analysis, hidden blood, culture, biochemistry – indicators, meaning thereof, interpretation of changes. | Classes | 1.00 | auditorium | |||||
| 7 | Urine analysis, the so-called microscopy, urine culture – indicators, meaning thereof, interpretation of changes. | Classes | 1.00 | auditorium | |||||
| 8 | Serological test: antibody formation, antibody classes. Rapid and confirmatory tests. | Classes | 1.00 | auditorium | |||||
| 9 | Laboratory diagnostics of M.tuberculosis – available methods, time of implementation and accuracy thereof. Introduction to polymer chain reaction (PCR). | Classes | 1.00 | auditorium | |||||
| 10 | Histological examination – definition, indications, methods to be used, interpretation of results. | Classes | 1.00 | auditorium | |||||
| 11 | Punctures: therapeutic and diagnostic indications. Type of collection. Examination possibilities. Interpretation of results. | Classes | 1.00 | auditorium | |||||
| 12 | Bone marrow examination – indications, abnormalities and their interpretation. | Classes | 1.00 | auditorium | |||||
| Topic Layout (Part-Time) | |||||||||
| No. | Topic | Type of Implementation | Number | Venue | |||||
| 1 | Carbohydrate metabolism – digestion and absorption of carbohydrates, glycogen metabolism (glycogenolysis, glycogenogenesis), glycolysis, pentose pathway, gluconeogenesis. Functions of carbohydrates in the human body. | Lectures | 1.00 | auditorium | |||||
| 2 | Lipid metabolism – digestion and absorption, lipolysis and lipogenesis, phospholipid and cholesterol metabolism, fatty acids and ketones. Functions of lipids in the human body. | Lectures | 1.00 | auditorium | |||||
| 3 | Protein metabolism: digestion and absorption, biosynthesis of amino acids and complex proteins. Functions of proteins in the human body. | Lectures | 1.00 | auditorium | |||||
| 4 | Possibilities of laboratory diagnostics: classification, material and methods used, their specificity and sensitivity. | Lectures | 1.00 | auditorium | |||||
| 5 | Complete blood count, blood biochemistry, blood culture, cytogenetic examination – indicators, meaning thereof, interpretation of changes. | Classes | 1.00 | auditorium | |||||
| 6 | Fecal examination: fecal analysis, hidden blood, culture, biochemistry – indicators, meaning thereof, interpretation of changes. | Classes | 1.00 | auditorium | |||||
| 7 | Urine analysis, the so-called microscopy, urine culture – indicators, meaning thereof, interpretation of changes. | Classes | 1.00 | auditorium | |||||
| 8 | Serological test: antibody formation, antibody classes. Rapid and confirmatory tests. | Classes | 1.00 | auditorium | |||||
| 9 | Laboratory diagnostics of M.tuberculosis – available methods, time of implementation and accuracy thereof. Introduction to polymer chain reaction (PCR). | Classes | 1.00 | auditorium | |||||
| 10 | Histological examination – definition, indications, methods to be used, interpretation of results. | Classes | 1.00 | auditorium | |||||
| 11 | Punctures: therapeutic and diagnostic indications. Type of collection. Examination possibilities. Interpretation of results. | Classes | 1.00 | auditorium | |||||
| 12 | Bone marrow examination – indications, abnormalities and their interpretation. | Classes | 1.00 | auditorium | |||||
| Assessment | |||||||||
| Unaided Work: | 1. Preliminary theoretical preparation according to the topic of the class. 2. Independent work – a report or presentation on one of the topics of the class, which the student will have to study independently according to the specified literature sources and write a report about it or present the findings during the class. | ||||||||
| Assessment Criteria: | 1. Independent work (additional work assessment criteria – correspondence of the content of the work to the chosen topic, the student’s personal contribution, the student’s level of knowledge) – 50%. 2. Written multiple choice test – 50%. | ||||||||
| Final Examination (Full-Time): | Exam (Written) | ||||||||
| Final Examination (Part-Time): | Exam (Written) | ||||||||
| Learning Outcomes | |||||||||
| Knowledge: | While cooperating in different fields, students will gain deeper knowledge and comprehension of biochemical processes in the human body. Students will be able to describe and classify modern laboratory diagnostic methods, their indications. Students will define how the test results are formed, what they mean, how to interpret them from a medical point of view. According to the changes in the test results, students will formulate and explain the meaning of these changes, possible causes and potential consequences. | ||||||||
| Skills: | Students will be able to independently create a data analysis plan for research aimed at human disease laboratory diagnostics, as well as to implement the developed plan; will be able to integrate laboratory examination into the design of disease diagnostic research, understanding the nature of the examination and the changes observed. | ||||||||
| Competencies: | When using patient data, students will be able to qualitatively analyse the results of disease diagnostics, differential diagnosis; will critically evaluate changes in test results not only from a statistical but also from a medical point of view. Students will be able to professionally cooperate with colleagues, using and understanding biochemical and laboratory terms. When working with patient data, students will follow the principles of medical ethics. | ||||||||
| Bibliography | |||||||||
| No. | Reference | ||||||||
| Required Reading | |||||||||
| 1 | Victor W. Rodwell, David A. Bender, Kathleen M. Botham, Peter J. Kenelly, P. Anthony Weil. Harper’s Illustrated Biochemistry, Thirty-first edition. Lange, 2018. | ||||||||
| 2 | Goldman L, Schafer AI. Goldman's Cecil Medicine, Twenty-Fifth Edition. Saunders, 2016 | ||||||||
| 3 | Chernecky Cynthia C., Berger Barbara J. Laboratory tests and diagnostic procedures, Sixth edition. Elsevier, 2013. | ||||||||
| 4 | McPherson, Richard A., Pincus, Matthew R. Henry’s. Clinical Diagnosis and Management by Laboratory Methods, Twenty-Third edition. Elsevier, 2017. | ||||||||
| Other Information Sources | |||||||||
| 1 | https://www.clinicalkey.com | ||||||||
| 2 | http://www.who.int/ | ||||||||
| 3 | http://site.ebrary.com/lib/rsub | ||||||||
| 4 | https://jmd.amjpathol.org | ||||||||
| 5 | https://emedicine.medscape.com/ | ||||||||
