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Sonochemical technology for bioactive bone regeneration scaffold production (SONOSCA)

Project/agreement No.
Project funding
60 000.00 EUR
Project manager
Project realization
01.01.2012. - 31.12.2014.


Aim of the project is to accelerate the bone ingrowth process in the pores of the scaffolds and reduce the risk of inflammatory processes
To verify the feasibility of creation of biologically active hierarchical hybrid nanostructures on the
scaffold surface that is mimicking natural bone using sonochemical methods


The main project innovation is to use a sonochemical process to coat polymer scaffolds with resorbable nano hydroxyapattite (HAP) and nano tricalcium phosphate (TCP). HAP is commonly assumed to be non-resorbable in the organism, but the developed by us microwave solvothermal synthesis processes permits to modify its nanostructure to make it fully resorbable. The sonochemical coating process willpermit to create hybrid bioactive nanoceramic coatings. Such coatings will tremendously increase the scaffold biocompatibility. As a secondary objective, we will show that properties of ceramic scaffolds coated with such a hybrid coating will be improved as well, compared to the non-coated ones. The potential of sonochemical methods for radical improvement of the scaffolds for bone regeneration will be demonstrated. The technology can be easily scaled up for larger structures or serial production. The project will open the way towards clinical tests as an intermediate stage before commercialisation

Project partners

  • Institute of High Pressure Physics, PAS (Poland) - Lead partner
  • Riga Technical university (Latvia)
  • PV Nano Cell Ltd (Israel)