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Sandra Lejniece

Study Course Description

Course Description Statuss:Approved
Course Description Version:4.00
Study Course Accepted:09.09.2019
Study Course Information
Course Code:ISK_061LQF level:Level 6
Credit Points:1.00ECTS:1.50
Branch of Science:Medicine; Internal MedicineTarget Audience:Medicine
Study Course Supervisor
Course Supervisor:Sandra Lejniece
Study Course Implementer
Structural Unit:Department of Internal Diseases
The Head of Structural Unit:Aivars Lejnieks
Contacts:Rīga, Hiprokrāta iela 2, iskatrsu[pnkts]lv, iskatrsu[pnkts]lv, +371 67042338
Study Course Planning
Full-Time - 1. Semester No.
Lectures (number)Lecture Length (academic hours)Total Contact Hours of Lectures0
Classes (number)5Class Length (academic hours)4Total Contact Hours of Classes20
Total Contact Hours20
Study course description
Preliminary Knowledge:
1. Hematopoiesis, blood cell division and maturation. 2. Pathological physiology and pathological anatomy of hematological diseases. 3. Changes in blood analysis.
The aim of the course – give students the knowledge of haematological diseases. To promote the acquisition of knowledge of diseases pathogenesis, and clinical manifestations. Help raise awareness of the laboratory analyses, in addition to the examination methods that are used in cases of haematological diseases. Learn differential diagnostic and treatment principles of haematological diseases.
Topic Layout (Full-Time)
No.TopicType of ImplementationNumberVenue
1Acute leukemia. Myelodisplastic syndrome. Aplastic anemia. Definition, causes, pathogenesis, clinical manifestations, signs, changes in blood and bone marrow analysis, additional analyses, diagnosis approval and diferentialdiagnosis, complications, treatment principles (chemotherapy, bone marrow/peripheral stem cells transplantation, supportive treatment), prognosis of those diseases. Neutropenia.Classes1.00clinical base
2Chronic lymphocytic leukemia, definition, causes, pathogenesis, symptoms and signs, changes in blood and bone marrow analyses, other investigations, complications, staging systems (Rai, Binet), diferencialdiagnosis, treatment, prognosis. Concept of chronic prolymphocytic leukemia, hairy cell leukemia. Hemolytic anemias – definition, causes, clasification, concept of clinical and laboratory diagnostic. Autoimmune hemolytic anemia. Hereditary hemolytic anemia.Classes1.00clinical base
3Multiple myeloma – definition, pathogenesis, simptoms and singns, changes in blood and bone marrow analyses, diagnostic of M-gradient, staging, diferentialdiagnosis, complications, treatment, prognosis. Concept of solitary plasmacytoma, Waldenstrom disease. Monoclonal gammopathy of undetermined significance.Classes1.00clinical base
4Lymphoma: Hodgkin's disease, non Hodgkin's lymphoma – definition, causes, pathogenesis, symptoms and signs, staging, changes in analyses, additionally analyses (histology, CT, PET), diferencialdiagnosis, treatment, prognosis.Classes1.00clinical base
5Chronic myeloproliferative leukemias: chronic myelogeneus leukemia (CML), polycythemia vera, myelofibrosis, essential thrombocythemia – definition, changes in blood and bone marrow analyses, additional investigations, staging, diferentialdiagnosis, treatment, prognosis. Secundary erythrocytosis and trombocytosis, causes.Classes1.00clinical base
Unaided Work:
1. Individual work with the patient – collection of anamnesis, examination interpretation, treatment planning, formulation of a possible diagnosis. 2. Obtaining additional information about a particular subject.
Assessment Criteria:
1. Tests during the lessons. 2. Situation tasks during the lessons. 3. Written examination (test questions, at least 75% of correct answers).
Final Examination (Full-Time):Test (Semester)
Final Examination (Part-Time):
Learning Outcomes
Knowledge:On successful completion of the course, students will gain knowledge of the haematological diseases mentioned in the course guide.
Skills:On successful completion of the course, students will be able to recognise and make a laboratory or other examination plan, classify and confirm the diagnosis, plan patient's treatment, explain the prognosis in cases of acute leukemia, myelodysplastic syndromes, aplastic anemia, chronic lymphocytic leukemia, multiple myeloma, Hodgkin's disease, Waldenström’s disease, plazmacitoma, non-Hodgkin's lymphomas, chronic myeloid leukemia, polycythemia vera, myelofibrosis, essential thrombocythemia and will be able to formulate a differential diagnosis in cases of haematological diseases.
Competencies:On successful completion of the course, students will be able to develop an investigation plan for haematological diseases, explain laboratory and other additional examination results, differentiate the changes and identify the most common haematological diseases.
1Klīniskā medicīna prof. A.Lejnieka redakcijā. Medicīnas Apgāds, 785-914, 2010
2S.Lejniece. Klīniskā hematoloģija. Nacionālais Medicīnas Apgāds, 2005.
3S.Lejniece. Klīniskā hematoloģija. Nacionālais Medicīnas Apgāds, 2002.
4Conn's Current Therapy 2019 Kellerman, Rick D., MD; Rakel, David P., MD, 2019 by Elsevier Inc
5The Merc Manual. Tventieth Edition, Centennial Edition, 2019.
6Essential Haematology. 7th edition. A.V.Hoffbrand, P.A.H.Moss. Wiley-Blackwell, 2015.
1Hoffbrand's Essential Haematology (Essentials) 7th Edition by A. Victor Hoffbrand and Paul A. H. Moss, Willey Blackwell, 2015.
2Postgraduate Haematology by A. Victor Hoffbrand and Douglas R. Higgs, 2016.
3Haematology: A Core Curriculum 1st Edition by Barbara Jane Bain, 2010
4Blood Cells: A Practical Guide by Barbara J. Bain, Fifth Edition Wiley Blackwell, 2015.
5Dacie and Lewis Practical Haematology E-Book 12th Edition, Kindle Edition by Barbara J. Bain, Imelda Bates, Mike A Laffan, 2017.
6Chronic myeloid leukaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up A. Hochhaus, S. Saussele, G. Rosti, F.-X. Mahon, J. J. W. M. Janssen, H. Hjorth-Hansen, J. Richter, C. Buske,on behalf of the ESMO Guidelines Committ
7Multiple Myeloma: ESMO Clinical Practice GuidelinesPublished in 2017 – Ann Oncol (2017) 28 (suppl 4): iv52–iv61. Authors: P. Moreau, J. San Miguel, P. Sonneveld, M. V. Mateos, E. Zamagni, H. Avet-Loiseau, R. Hajek, M. A. Dimopoulos, H. Ludwig, H. Ein
8Chronic Lymphocytic Leukaemia: ESMO Clinical Practice Guidelines Published in 2015 – Ann Oncol (2015) 26 (suppl 5): v78-v84. Authors: B. Eichhorst, T. Robak, E. Montserrat, P. Ghia, P. Hillmen, M. Hallek, C. Buske
9Acute Myeloblastic Leukaemia in Adult Patients: ESMO Clinical Practice Guidelines Published in 2013 – Ann Oncol 2013; 24 (Suppl 6): vi138-vi143. Authors: M.F. Fey, C. Buske
10Pocket Oncology (Pocket Notebook) (Kindle Edition) by Alexander Drilon, Michael Postow, 2019.
11Atlas of Hematology – Nivaldo Medeiros M.D. (RSU biblioteka)
12Practical transfusion medicine. Michael F. Murphy, David J Roberts, Mark H Yazer Hoboken, NJ: John & Sons Inc., 2017.
13Global Hematology by David J Roberts; D J Weatherall, Elservier, 2016.
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