The aim of the proposed project is to develop and test the efficacy and feasibility of an innovative, combined treatment approach for home use, incorporating both non-invasive brain stimulation (NIBS) and an action videogame designed to enhance emotional cognitive control in patients suffering from MDD. This novel intervention approach combines stimulation over dorsolateral prefrontal cortex (DLPFC) along with direct training of cognitive control and emotion regulation mechanisms, known to abnormally operate in depression.