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Work experience

2010 - Present

Assistant

Rīga Stradiņš University (RSU), Faculty of Medicine, Department of Biology and Microbiology

2006 - Present

Scientific collaborator

RSU, Scientific laboratory of molecular genetics

2011 - 2016

General practitioner - substitute

SIA "RSU Ambulance"

2009 - 2012

Medical doctor - resident (speciality - Family medicine)

SIA "RSU Ambulance"

2008 - 2010

Lecturer

RSU, Faculty of Medicine, department of Biology and Microbiology (prev. Department of Medical Biology and Genetics)

2010 - 2010

Acting assistant

RSU, Faculty of Medicine, Department of Biology and Microbiology

2006 - 2010

Laboratory assistant

RSU, Faculty of Medicine, Department of Medical Biology and Genetics

2006 - 2006

Hospital attendant

Pauls Stradins Clinical University Hospital

Present

Assistant

Faculty of Medicine, Department of Biology and Microbiology

Education and training

2013 - 2017

PhD programme "Medicine"

Rīga Stradiņš University

2017

Geneticist, certificate No 784-AP-S

2009 - 2012

General practitioner

Rīga Stradiņš University, Residency in medicine, Faculty of Continuing Education, Study programme „Family medicine”

1991 - 2010

Primary education

Auce's Secondary School

2003 - 2009

Medical Doctor

Rīga Stradiņš University, Faculty of Medicine

2000 - 2003

Secondary education

Auce's Secondary School

Achievements

Continuing education a.o. qualification upgrade

1.03.2017., 08.03.2017., 15.03.2017. "How can Google tools help in studies and teaching?"


The V-th International school on molecular genetics for young scientists „Variability of the genome", Zvenigorod (Moscow region), Russia (03.12. – 07.12.2012.)​

Field of research

  • Identification of genetical factors influencing the clinical course of monogenic liver diseases (Wilson disease, Gilbert syndrome, Hereditary haemochromatosis, Alpha1-antitrypsin deficiency and other)
  • Population genetics - usage of uniparental markers (mtDNA and Y chromosome)

Lectured study course

Medical Genetics (Faculty of Dentistry)

Molecular Biology and Genetics (Faculty of Medicine)

Medical Genetics

Molecular Biology and Genetics

Molecular Biology

Biology and Genetics

Biology and Medical Genetics

Cytology and Genetics

Medical Microbiology

Projekti

2009.-2013. Investigator. „Genetic research of aethiology, pathogenesis of diseases and ageing in Latvian population" sub-project 02 "Polimorphic variants of genes involved in xenobiotic metabolism and their relevance to the pathology". Latvian Science Council funds​​.

2009.-2012. Investigator. „Genetically determined liver metabolism modulation in case of different liver disorders". Latvian Science Council funds​.

Dalība biedrībās, organizācijās u.tml.

2016. - present: Latvian Association of Human Genetics - a member​

2013. - present: Latvian Medical Association - a member

Awards and recognitions


2009. Award (3rd place) at 4th Baltic Sea Region Conference in Medical Sciences, research „High frequency of Wilson Disease and new mutations found in Latvia" (Warsaw)​

Publikācijas

Research articles​​

Association of ARID5B genetic variants with risk of childhood B cell precursor acute lymphoblastic leukaemia in Latvia [Elektroniskais resurss] / M.Kreile, D.Rots, A.Zarina, Z.Kovalova, L.Gailite ...[et al.] // Asian Pacific Journal of Cancer Prevention : APJCP [Elektroniskais resurss]. - Vol.19, No.1 (2018, Jan.), p.91-95. - Starptautiski citējamā izdevumā. - Pieejas veids: Tīmeklis WWW.URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844642/

Nagle, Erika. Challenges in teaching genetics for preclinical students of dentistry [Elektroniskais resurss] / E.Nagle, A.Zarina // JSM Oro Facial Surgeries [Elektroniskais resurss]. - Vol.3, Issue1 (2018), article No.1011, 2 p. - Resurss aprakstīts 2019.g. 18.febr. - Pieejas veids: Tīmeklis WWW.URL: https://www.jscimedcentral.com/OroFacial/orofacial-3-1011.p…

Population genetics of Latvians in the context of admixture between North-Eastern European ethnic groups / A.Puzuka, A.Zarina, L.Gailite (Piekuse) ...[et al.] // Proceedings of the Latvian Academy of Sciences. Sect.B. - Vol.72, No.3 (2018, June), p.131-151. - Starptautiski citējamā izdevumā.

Genetic variation spectrum in ATP7B gene identified in Latvian patients with Wilson disease [Elektroniskais resurss] / A.Zarina, M.Kreile, A.Chernushenko, I.Pukite, Z.Krumina, A.Krumina, B.Rozentale, L.Piekuse ...[et al.] // Molecular Genetics & Genomic Medicine [Elektroniskais resurss]. - Vol.5, No.4 (2017, June), p.405-409. - Starptautiski citējamā izdevumā. - Pieejas veids: Tīmeklis WWW.URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511797/

MDR1 gēna polimorfismu rs2032582 un rs1045642 saistība ar hroniska C vīrushepatīta attīstības risku un gaitu / D.Rots, M.Kreile, A.Zariņa, L.Piekuse ...[u.c.] // Zinātniskie raksti : 2015.g. medicīnas nozares pētnieciskā darba publikācijas / Rīgas Stradiņa universitāte. - Rīga, 2016. - 319.-326.lpp.

Association between inherited monogenic liver disorders and chronic hepatitis C [Elektroniskais resurss] / L.Piekuse, M.Kreile, A.Zarina, Z.Steinberga, A.Krumina ...[et al.] // World Journal of Hepatology [Elektroniskais resurss]. - Vol.6, No.2 (2014, Febr.), p.92-97. - Starptautiski citējamā izdevumā. - Pieejas veids: Tīmeklis WWW.URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935058/

MTHFR gēna polimorfismu C677T un A1298C saistība ar vīriešu neauglību / M.Kreile, L.Piekuse, A.Puzuka, A.Zariņa, J.Ērenpreiss ...[u.c.] // Zinātniskie raksti : 2011.g. medicīnas nozares pētnieciskā darba publikācijas / Rīgas Stradiņa universitāte. - Rīga, 2012. - 1.sēj., 270.-275.lpp.

Abstracts​​

Case series of Wilson’s disease - are there specific multiparametric liver ultrasound findings? [Elektroniskais resurss] / L.Skrule, M.Radzina, A.Zarina, I.Tolmane // 7th Baltic Congress of Radiology (BCR) (Kaunas, Lithuania, Oct.4-6, 2018) [Elektroniskais resurss] : Online Abstract Book. - P.35. - Resurss aprakstīts 2019.g. 20.febr. - Pieejas veids: Tīmeklis WWW.URL: https://eu.eventscloud.com/file_uploads/39ced8700ee445ea7b4…

Is it sufficient with direct sequencing of ATP7B gene coding regions to diagnose Wilson disease? [Elektroniskais resurss] / A.Zarina, A.Tutane, D.Rots, M.Kreile, I.Pukite, Z.Krumina, L.Gailite ...[et al.] // Environmental and Experimental Biology [Elektroniskais resurss]. - Vol.16, No.3 (2018), p.279. - 7th Baltic Genetics Congress (Riga, Latvia, Oct.24-27, 2018) : Abstracts. - Pieejas veids: Tīmeklis WWW.URL: http://eeb.lu.lv/EEB/201810/EEB_XVI_abstracts.pdf. - Starptautiski citējamā izdevumā.

Vilsona slimība Latvijā : 17 gadu pieredze molekulārajā diagnostikā / A.Zariņa, M.Kreile, I.Tolmane, A.Černušenko, G.Čerņevska, I.Puķīte, Z.Krūmiņa, L.Gailīte // 2018.gada Zinātniskās konferences tēzes (Rīga, 2018.g. 22.-23.martā) / Rīgas Stradiņa universitāte. - Rīga, 2018. - 242.lpp.

ATOX1 gēna variantu ietekme uz Vilsona slimības klīnisko gaitu / A.Zariņa, A.Černušenko, I.Puķīte, Z.Krūmiņa, M.Kreile, L.Piekuse ...[u.c.] // 2017.gada Zinātniskās konferences tēzes (Rīga, 2017.g. 6.-7.aprīlī) / Rīgas Stradiņa universitāte. - Rīga, 2017. - 292.lpp.

The results of genetic diagnostics of ATP7B gene mutations among individuals with high risk of Wilson disease / H.Makukh, L.Piekuse, A.Zarina ...[et al.] // Scientific and Practical Conference "Cystic fibrosis in Ukraine" with Symposium "Orphan diseases in children and adults" (Lviv, Ukraine, Oct.12-14, 2017) : Abstract Book. - Lviv, 2017. - P.43-44.

Is COMMD1 gene a modifier locus of Wilson disease? [Elektroniskais resurss] / A.Zarina, L.Piekuse, M.Kreile, I.Pukite, Z.Krumina ...[et al.] // European Journal of Human Genetics [Elektroniskais resurss]. - Vol.24, e-Suppl.1 (2016, May), p.93. - Starptautiski citējamā izdevumā. - Pieejas veids: Tīmeklis WWW.URL: https://www.eshg.org/fileadmin/www.eshg.org/conferences/201…

Vilsona slimības pirmās klīniskās izpausmes bērniem vecumā līdz 18 gadiem Latvijas populācijā / A.Zariņa, L.Piekuse, M.Kreile, I.Puķīte, Z.Krūmiņa ...[u.c.] // 2016.gada Zinātniskās konferences tēzes (Rīga, 2016.g. 17.-18.martā) / Rīgas Stradiņa universitāte. - Rīga, 2016. - 162.lpp.

Kritēriji Vilsona slimības klīniskajai un molekulārajai diagnostikai / A.Zariņa, L.Piekuse, M.Kreile, A.Černušenko, I.Puķīte, Z.Krūmiņa ...[u.c.] // 2015.gada Zinātniskās konferences tēzes (Rīga, 2015.g. 26.-27.martā) / Rīgas Stradiņa universitāte. - Rīga, 2015. - 173.lpp.

Not typical North-European ATP7B gene mutation in Latvian patients with Wilson disease / A.Zarina, L.Piekuse, M.Kreile, I.Pukite, Z.Krumina, A.Krumina ...[et al.] // European Journal of Human Genetics. - Vol.23, Suppl.1 (2015, June), p.144-145. - Starptautiski citējamā izdevumā.

Germline variants of ARID5B as possible risk factors for childhood acute lymphoblastic leukemia in Latvia / M.Kreile, L.Piekuse, D.Rots, A.Zarina ...[et al.] // European Journal of Human Genetics. - Vol.22, Suppl.1 (2014, May), p.503. - Starptautiski citējamā izdevumā.

HFE gēna mutāciju C282Y un H63D saistība ar Vilsona slimību Latvijas pacientiem / A.Zariņa, L.Piekuse, M.Kreile, A.Černušenko, Z.Krūmiņa ...[u.c.] // 2014.gada Zinātniskās konferences tēzes (Rīga, 2014.g. 10.-11.aprīlī) / Rīgas Stradiņa universitāte. - Rīga, 2014. - 146.lpp.

Mutations in genes HFE, SERPINA1, CFTR in Wilson’s disease patients in Latvia / A.Zarina, L.Piekuse, M.Kreile, Z.Steinberga, A.Chernusenko, Z.Krumina ...[et al.] // European Journal of Human Genetics. - Vol.22, Suppl.1 (2014, May), p.397. - Starptautiski citējamā izdevumā.

Viena nukleotīda polimorfismu, kas lokalizēti gēnos IKZF1, ARID5B, MDR1 un CEBPE, saistība ar akūtu limfoblastu leikozi bērnu vecumā / M.Kreile, L.Piekuse, D.Rots, A.Zariņa, Ž.Kovaļova ...[u.c.] // 2014.gada Zinātniskās konferences tēzes (Rīga, 2014.g. 10.-11.aprīlī) / Rīgas Stradiņa universitāte. - Rīga, 2014. - 248.lpp.

Žilbēra sindroma mutāciju spektrs Latvijas populācijā / L.Piekuse, M.Kreile, A.Zariņa, Z.Šteinberga, A.Černušenko ...[u.c.] // 2014.gada Zinātniskās konferences tēzes (Rīga, 2014.g. 10.-11.aprīlī) / Rīgas Stradiņa universitāte. - Rīga, 2014. - 169.lpp.

Association between dyslipidaemia and mutations in the genes PCSK9, LDLR / A.Zarina, L.Piekuse, M.Kreile ...[et al.] // European Journal of Human Genetics. - Vol.21, Suppl.2 (2013, June), p.258. - Starptautiski citējamā izdevumā.

Association between snp rs 4132601 in gene IKZF1 region and childhood acute lymphoblastic leukemia / M.Kreile, L.Piekuse, A.Zarina, Z.Kovalova ...[et al.] // European Journal of Human Genetics. - Vol.21, Suppl.2 (2013, June), p.536. - Starptautiski citējamā izdevumā.

Inheritance of Wilson's disease and its clinical appearance in four unrelated families in Latvia / A.Zarina, L.Piekuse, M.Kreile ...[u.c] // Collection of Scientific Papers 2013 : Research articles in medicine & pharmacy : Abstracts from VI Latvian Gastroenterology Congress with International participation (Riga, Latvia, Dec.7, 2013) / Riga Stradiņš University. - Riga, 2013. - Suppl.1, p.48.

Inherited monogenic liver pathology association with chronic viral hepatitis c infection / L.Piekuse, M.Kreile, A.Zarina ...[u.c.] // Latvijas Universitātes 71. Zinātniskās konferences Medicīnas sekcijas tēžu apkopojums (Rīga, 2013.g. 15.febr.) / Latvijas Universitāte. - Riga, 2013. - 59.lpp.

PCSK9, UGT1A1 un LEP gēnu polimorfismu saistība ar seruma lipīdiem pacientiem ar dislipidēmiju / A.Zariņa, L.Piekuse, M.Kreile, S.Gintere ...[u.c.] // 2013.gada Zinātniskās konferences tēzes (Rīga, 2013.g. 21.-22.martā) / Rīgas Stradiņa universitāte. - Rīga, 2013. - 146.lpp.

Viral hepatitis C infection influencing host genetic factors / L.Piekuse, M.Kreile, A.Zarina ...[et al.] // European Journal of Human Genetics. - Vol.21, Suppl.2 (2013, June), p.146. - Starptautiski citējamā izdevumā.

Association of non-alcoholic fatty liver disease and hypercholesterolemia with mutations on the genes LEP, UGT1A1, ATP7B / A.Zarina, L.Piekuse, M.Kreile, A.Krumina ...[et al.] // European Journal of Human Genetics. - Vol.20, Suppl.1 (2012, June), p.342. - Starptautiski citējamā izdevumā.

Viral hepatitis C infection influencing host genetic factors / L.Piekuse, M.Kreile, A.Zarina ...[et al.] // European Journal of Human Genetics. - Vol.21, Suppl.2 (2013, June), p.146. - Starptautiski citējamā izdevumā.

Diagnosing of inherited liver disorders in Latvia in period from 2001-2010 / L.Piekuse, M.Kreile, A.Zarina, I.Kempa, A.Cernušenko, A.Krumina ...[et al.] // V Latvian Gastroenterology Congress with International Participation (Riga, Latvia, Nov.12, 2011) : Abstracts Book / Riga Stradiņš University. - Riga, 2011. - P.9.

Influence of inherited liver disorders on viral hepatitis C clinical outcome : [abstract] / L.Piekuse, M.Kreile, A.Zarina ...[et al.] // 21st Conference of the Asian Pacific Association for the Study of the Liver (Bangkok, Thailand, Febr.17-20, 2011). - Bangkok, 2011. - [Nav norādītas lpp.].

Mutation spectrum of Wilson disease in Latvia / A.Zarina, L.Piekuse, M.Kreile ...[et al.] // In Vivo : International Journal of Experimental and Clinical Pathophysiology and Drug Research. - Vol.25, N 3, (2011, May-June), p.574. - Starptautiski citējamā izdevumā.

No association between functional polymorphisms in MTHFR and childhood schizophrenia in Latvian population / M.Kreile, L.Piekuse, A.Zarina ...[et al.] // European Journal of Human Genetics. - Vol.19, Suppl.2 (2011, May), p.326. - Starptautiski citējamā izdevumā.

Hereditary haemochromatosis association with other inherited liver disorders : [abstract] / L.Piekuse, M.Kreile, A.Zariņa, B.Lāce, A.Krūmiņa ...[et al.] // The 1st OpenGENE Young Investigator Workshop in Baltic Region "GWAS: from genotyping to sequencing" (Tartu, Estonia, Aug.22-26, 2010). - Tartu, 2010. - P.27.

Inherited genetic liver disorder impact on VHC infection in Latvia / L.Piekuse, M.Kreile, A.Zariņa, B.Lāce, A.Krumina ...[et al.] // European Journal of Human Genetics. - Vol.18, Suppl.1 (2010, June), p.265. - Starptautiski citējamā izdevumā.

Vilsona slimības izraisošās mutācijas H1069Q biežums bērniem līdz 18 gadu vecumam Latvijas populācijā / A.Zariņa, L.Piekuse, M.Kreile, A.Krūmiņa ...[u.c.] // 2010.gada Zinātniskās konferences tēzes (Rīga, 2010.g. 18.-19.martā) / Rīgas Stradiņa universitāte. - Rīga, 2010. - 240.lpp.

Supervised study course

Biology

Biology and Genetics

Biology and Medical Genetics

Cytology and Genetics

Contacts

Colleagues

Ilze Grope
Dean, Academic Staff
Jana Pavāre
Dean, Academic Staff
Ivars Vanadziņš
Academic Staff, Director, Lead researcher, scientific project manager
Ludmila Vīksna
Head of the Department, Academic Staff, Chair, Convent of Councillors
Dace Zavadska
Academic Staff, Lead Researcher, Lead researcher, scientific project manager
Jānis Gardovskis
Head of the Unit, Academic Staff, Chair of the Senate
Sandra Lejniece
Dean, Director of Study Programme
Dace Gardovska
Head of the Department, Academic Staff, Lead Researcher, Member of RSU Council
Andris Jumtiņš
Head of the Department, Academic Staff, Member of RSU Council
Oskars Kalējs
Academic Staff, Lead Researcher
Ilze Konrāde
Academic Staff, Director of Study Programme
Pēteris Tretjakovs
Head of the Department, Director of Study Programme
Zanda Daneberga
Academic Staff, Lead Researcher, Deputy Chairperson
Ilona Hartmane
Academic Staff, Acting Head of Department
Regīna Kleina
Academic Staff
Juta Kroiča
Head of the Department, Academic Staff