Lead Researcher, Institute of Oncology
2014 - Present
Leading Researcher (Research)
RSU Institute of Oncology, Laboratory of Molecular Genetics
2014 - Present
Acting Assistant Professor
Faculty of Medicine, Department of Biology and Microbiology
2014 - 2019
Head of the Embryology laboratory
SIA "Novella Medical"
2008 - 2016
Biotechnologist Cell Transplantation Centre, Pauls Stradins Clinical University hospital
Cell Transplantation Centre, Pauls Stradins Clinical University hospital
2005 - 2013
Laboratory of Bioanalytical methods and Biodosimetry, University of Latvia
2005 - 2013
division of Microbiology and Biotechnology, Faculty of Biology, University of Latvia
2002 - 2005
Retinoid research laboratory, Department of Food Sciences and Human Nutrition, Michigan State University
2000 - 2001
Laboratory of Molecular Genetics, Institute of Genetics, University of Regensburg
1997 - 2000
Laboratory of microorganism and plant genetics, Faculty of Biology, University of Latvia
Education and training
2005 - 2011
University of Latvia
Title: "Effect of retinoid acid on THF-beta2 protein and mRNA synthesis during early cardiovascular development in vivo and in vitro"
Ph.D.biochem., prof. Maija H.Zile
Dr.habil.biol., prof. Indrikis Muiznieks
Dr.habil.biol., prof. Pauls Pumpens (Faculty of Biology, University of Latvia)
Dr.habil.med., prof. Vija Zaiga Klusa (Faculty of Medicine, University of Latvia)
Ph.D.biochem., prof. Margus Pooga (Institute of Molecular and Cell Biology, University of Tartu, Estonia)
1999 - 2000
Master’s degree of Life Sciences in Biology
University of Latvia
Title: "DNA-methyltransferase gene analysis in Volvox carteri"
Porf. Rudiger Schmidt
Prof., Indrikis Muiznieks
1995 - 1999
Bachelor's degree in Life Sciences in Biology
The University of Latvia
Title: "Factors involved in formation of deletions caused by CpG-rich promoter regions of ret-protooncogene"
Prof. Indrikis Muiznieks
L'Oreal and UNESCO award "For Women in Science", in collaboration with Latvian Science council in year 2010.
2015. june - ERASMUS mobility programme at Cancer research UK institute Cambridge, UK.
2013. august - IBRO (Interantional Brain Research Organisation) course (80 hours) "Neuroscience" Riga, Latvia
2012. october - at the University hospital of Ulme, (Universitatesklinikum Ulm, Klinik fur Herz-, Thorax and Gefachirurgie), Ulm, Germany
2012. february - Flow cytometry course IFCC/ESCCA Beckman Coulter Flow Cytometry course for advanced users, Leipzig, Germany
20122. december - qPCR biostatistics course about qPCR analysis and gene expression profiling, TATAA Biocenter, Prague, Chezh Republic
2009. december - practical studies on work with human embryonic stem cells, INSERM laboratory (prof., M.Puceat), Evry, France
2009. march - Flow cytometry in oncohematology course in St.Petersburg University Diagnostics laboratory, St Petersburg, Russia
2007.june, 2008. june - Transplatation laboratory at ERASMUS Medical Center, Rotterdam, Netherlands
2007.may - Beta cell differentiation courses, University of Bath, Bath, UK and Strasbourg, France
2006.june - practical methods on Langerhans island isolation and preparation for transplantation in type 1 diabetes patients, and learning on GMP facilities in the University of Uppsala, Uppsala, Sweden
2006.august - Baltic summer school for PhD students "Stem Cell Biology", University of Kiel, Kiel, Germany
2000.february - course in electronmicroscopy at University of Regenburg, Regensburg, Germany
Supervised study course
Horizontal Gene Transfer
Head of study course
Horizontal Gene Transfer
Lectured study course
Human Molecular Biology
Molecular Biology and Genetics
Topical Issues and Research Trends in Biomedicine
Supervised and reviewed student research papers
Master's theses: 7
Bachelor projects: 6
qualification papers: 8
doctoral theses: 2
Master's theses: 9
Bachelor projects: 15
qualification papers: 12
Riga Strains University project "Recapitulation of transcriptomic and phenotypic features of primary tumours in 3D organoid and spheroid cultures in vitro as potential model system for personalised medicine", Nr. 5.1./127/2019 principal investigator.
National research programm "Biomedicine for public health", 2014 – 2017, senior researcher. Main aim is to identify chemotherapy-resistant breast cancer cells. Identification of different cell types in patient material and comparison to existing breast cancer cell lines.
Riga Stradinš University project "Reconstruction of breast cancer genetic evolution based on proteomics in cancer cell cultures", 2014 – 2016, senior researcher. Analysis of the cells on protein level from breast cancer patients before and after therapy.
European Regional Development Fund (ERDF) project "Development of prophylactic skin regenerating polysaccharide and glycoprotein containing products of plant and fungal origin, use of them to elaborate compositions for hygiene and cosmetic products", 2012-2014, researcher. Testing products containing polysaccharides and glycoproteins on dermal fibroblasts and reference cell cultures, also using co-cultures of dermal fibroblasts and keratinocytes.
European Regional Development Fund (ERDF) project "Extraction and characterization of medical peat and its stabilization for use for hygiene and cosmetic products", 2012-2014, researcher. Medical peat extract testing on dermal fibroblasts and reference cell cultures.
A collaboration project (Riga Stradinš University, Riga Technical University and University of Latvia) supported by National Research program's activity 4.5 "New materials and technologies for biological tissue examination and replacement" 2010-2012, researcher. Isolation of rabbit mesenchymal cells from the subcutaneous abdominal fat and prepration of the cells for testing in vivo together with biomaterials for bone regeneration.
Dalība biedrībās, organizācijās u.tml.
since 2011, an expert of Science Council of Latvia
since 2006, a member of Association of Latvian Young Scientists
Awards and recognitions
Annual award of University of Latvia for "PhD thesis of the year", year 2011.
Scolarship for PhD studies supported from project "Supprot for PhD studies at University of Latvia" ESF (Nr. 2009/0138/1DP/184.108.40.206.2/09/IPIA/VIAA/004), 2009-2010.
Alterations of the stem-like properties in the breast cancer cell line MDA-MB-231 induced by single pulsed doxorubicin treatment
Pirsko, V., Čakstiņa, I., Nitiša, D., Samoviča, M., Daneberga, Z., Miklaševičs, E.
Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, 2019, 73(2), pp. 89-99.
An effect of culture media on epithelial differentiation markers in breast cancer cell lines MCF7, MDA-MB-436 and SkBr3
Pirsko, V., Cakstina, I., Priedite, M., Dortane, R., Feldmane, L., Nakazawa-Miklasevica, M., Daneberga, Z., Gardovskis, J., Miklasevics, E.
Medicina (Lithuania), 2018, 54(2),11
Electrically active and 3D porous TiO2-x ceramic scaffolds for bone tissue regeneration
Narkevica, I., Stipniece, L., Jakobsons, E., Cakstina, I., Ozolins, J.
Journal of the European Ceramic Society 2017, 37(2), pp. 833-840
Cartilage-derived extracellular matrix extract promotes chondrocytic phenotype in three-dimensional tissue culture.
Youngstrom DW, Cakstina I, Jakobsons E.
Artif Cells Nanomed Biotechnol. 2016 May;44(3):1040-7. doi: 10.3109/21691401.2015.1014091. Epub 2015 Feb 24.
Role of genetic factors on the effect of additional loading doses and two maintenance doses used to overcome clopidogrel hyporesponsiveness.
Latkovskis G, Urtane I, Knipse A, Peculis R, Cakstina I, Klovins J, Erglis A.
Medicina (Kaunas). 2014;50(1):19-27. doi: 10.1016/j.medici.2014.05.004. Epub 2014 Jun 6.
Primary culture of avian embryonic heart forming region cells to study the regulation of vertebrate early heart morphogenesis by vitamin A.
Cakstina I, Riekstina U, Boroduskis M, Nakurte I, Ancans J, Zile MH, Muiznieks I.
BMC Dev Biol. 2014 Feb 19;14:10. doi: 10.1186/1471-213X-14-10.
Transforming growth factor beta2 is negatively regulated by endogenous retinoic acid during early heart morphogenesis.
Ghatpande SK, Zhou HR, Cakstina I, Carlson C, Rondini EA, Romeih M, Zile MH.
Dev Growth Differ. 2010 Jun;52(5):433-55. doi: 10.1111/j.1440-169X.2010.01183.x.